Navigation Links
High-Dosage of Epirubicin and Cyclophosphamide may cause AML

Adjuvant chemotherapy with epirubicin and cyclophosphamide for early breast cancer// patients increased the risk of Acute myeloid leukemia or Myelodysplastic syndrome.

Recent study published in Journal of clinical oncology reports that early breast cancer patients undergoing chemotherapy with higher than standard cumulative doses of epirubicin and cyclophosphamide have an increased risk of developing Acute myeloid leukemia (AML) or Myelodysplastic syndrome (MDS).

This study was done by Dr. David Rogers and his team, in which they have proved that patients undergoing adjuvant therapy with higher than standard cumulative doses of epirubicin and cyclophosphamide for early stage of breast cancer are at increased risk of developing AML or MDS. It has been reported that though the long-term survival of these patients as increased following administration of these drugs, but the risk of developing secondary AML with or without MDS has been increased.

Epirubicin monitoring plan was started by Dr. Rogers collaboration with Gruppo Pfizer of Milan, Italy to undergo 19 randomized clinical trials for adjuvant therapy in early breast cancer, the study included 9796 patients started in early 1984, with follow up till 2001. In this follow-up study 30 patients developed AML/MDS. Both the cumulative doses of epirubicin and cyclophosphamide had independent risk factors for AML/MDS. Other factors such as age, radiotherapy, granulocyte colony stimulating factor and tamoxifen were not independently associated with AML/MDS.

Patients taking more than the standard cumulative dose of epirubicin was found to have an increased relative risk of 6.80. The standard dose of epirubicin was found to be 720 mg/m. For doses no higher than the standard dose, "the low risk of secondary leukemia does not differ significantly from the risk in patients not treated with epirubicin or who received hormonal therapy only," Dr. Rogers' team notes.

Both epi rubicin and cyclophosphamide were usually administered in combination and the 4760 patients who received the standard doses of epirubicin and cyclophosphamide (6300 mg/m), the 8-year cumulative probability of developing AML/MDS was 0.37%, compared with 4.97% of the 261 patients who received higher cumulative doses of both drugs.

"In clinical practice, the described regimens have a strong benefit to risk ratio," the authors conclude, "and patients and clinicians can be reassured that the risk of leukemia is likely to be low if the cumulative doses of these regimens are not exceeded."
'"/>




Related medicine news :

1. Kissing can cause Kaposi’s Sarcoma in AID
2. Kidney Stones - Interesting New Research implicates bacteria as its cause
3. Roller coasters – cause “Chronic Headache?
4. Starvation in pregnant women can cause heart disease to their children
5. And now they say infections can cause heart disease!!!!
6. And now they say infections can cause heart disease!!!!
7. Ticks may cause more diseases
8. Depression may cause delayed wound healing
9. Analgesic abuse - cause for chronic headache in children
10. Strong pain killers likely to cause miscarriage
11. Pressure on spine cause problems
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
(Date:6/23/2016)... June 23, 2016 The vast majority of ... dialysis facility.  Treatments are usually 3 times a week, ... visit, including travel time, equipment preparation and wait time. ... especially grueling for patients who are elderly and frail.  ... nursing and rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: