Navigation Links
Herpes Infects Cornea, Evades Immune Cells

Herpes virus has an unusual strategy for infecting cornea cells that may also explain how it evades the immune system, according to a study by researchers// at the University of Illinois at Chicago College of Medicine.

The study appears in the Sept. 25 issue of the Journal of Cell Biology.

Both strains of the herpes virus -- HSV-1, the strain that causes cold sores on the mouth, and HSV-2, genital herpes -- can infect the cornea, the clear, domed surface that forms the eye's outermost layer. Ocular herpes is the leading cause of infectious blindness in the United States, with 50,000 new or recurring cases each year.

In about one quarter of cases, the virus penetrates the first layer of the cornea to infect an inner layer, the stroma, making the disease much more difficult to treat.

Effective treatment is hampered by poor understanding of how the virus infects the stroma, says Deepak Shukla, assistant professor of ophthalmology and visual science and microbiology and immunology, and senior author of the paper. In their study, he and his coworkers determined that the HSV-1 virus enters stroma cells in a process similar to the way bacteria, viruses and other foreign invaders are engulfed by immune cells called phagocytes.

"In the electron microscope pictures, it looks like the stroma cells form long arms that reach out and collect the virus particles, and then wrap around them, forming a sac, and bring them into the cell body," Shukla said.

In phagocytes, ingested foreign particles are destroyed in the sacs, which are highly acidic. But even though the sacs formed by the stroma cells were similar to the phagocyte's sacs, Shukla said, the envelope containing the herpes virus genome emerges from the sac undamaged and able to infect the cell. "This raises the interesting possibility that herpes may be able to evade the immune system defenses in the same way," he said.

"Understanding herpes ' unusual pathway for infecting the stroma cells opens up new strategies for developing therapies against this potentially blinding disease and has implications for understanding other herpes virus infections," Shukla said. Christian Clement and Vaibhav Tiwari are co-first authors of the paper. Perry Scanlan, Beatrice Yue and Tibor Valyi Nagy also contributed to the study.

The study was supported by grants from the National Institutes of Health, a Career Development Award from Research to Prevent Blindness Inc. to Shukla and an American Heart Association postdoctoral fellowship to Tiwari.

UIC ranks among the nation's top 50 universities in federal research funding and is Chicago's largest university with 25,000 students, 12,000 faculty and staff, 15 colleges and the state's major public medical center. A hallmark of the campus is the Great Cities Commitment, through which UIC faculty, students and staff engage with community, corporate, foundation and government partners in hundreds of programs to improve the quality of life in metropolitan areas around the world.

Source-Newswise
'"/>




Related medicine news :

1. Drug Stops Herpes
2. Drug Found To Reduce The Transmission Of Herpes
3. Cancer Causing Herpes Virus At Last May Have A Cure
4. Treating Latent Herpes With Licorice
5. Experts Insist That Neonatal Herpes Be Reported Regularly
6. FDA to Revise Herpes Test Rules in the US
7. Protection against HIV and Herpes is possible with the Experimental Microbicide
8. Valtrex Prevents the Need for C-Section among Women Infected With Genital Herpes
9. Genital Herpes - No Symptoms But A Potent Carrier
10. FDA Approves Famvir For Genital Herpes
11. Genital Herpes Rate Down In US
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... faculty and staff members in 2017 who are passionate about making a difference ... in 1994 and headquartered in Tampa, UMA, a nonprofit healthcare educational institution, has ...
(Date:1/19/2017)... ... January 19, 2017 , ... For the third year running, ... and the surrounding area, is inaugurating a charity event to help raise ... as Lou Gehrig's disease or motor neurone disease, is a deadly neurological disorder ...
(Date:1/19/2017)... ... 2017 , ... The CHP suggests that California drivers can avoid hydroplaning as ... and increasing the space between themselves and other vehicles, according to a January 3 ... R. Hassanlou notes that, rain or shine, drivers should always incorporate safe driving practices ...
(Date:1/19/2017)... ... January 19, 2017 , ... "ProParagraph Basics is a set ... process for all media productions," said Christina Austin - CEO of Pixel Film ... self-animating paragraphs designed for multi-lined text purposes. Choose from presets with basic, ...
(Date:1/18/2017)... ... January 18, 2017 , ... A recent video posting of ... discussion about the benefits of fidgeting to relieve stress and anxiety. No one ... Their Think Ink Pen had just completed a successful Kickstarter campaign raising $67,000 on ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... PAUL, Minn. , Jan. 18, 2017 /PRNewswire-USNewswire/ ... developer of medical devices using neuroblocking technology to ... today announced the pricing of an underwritten public ... million, prior to deducting underwriting discounts and commissions ... The offering is comprised of Class A Units, ...
(Date:1/18/2017)... PORTLAND, Oregon and PUNE, India ... report published by Allied Market Research, titled, "Breast Imaging Technologies ... projects that the global breast imaging technologies market size was ... reach $4,502 million by 2022, growing at a CAGR of ... and Europe together accounted for ...
(Date:1/18/2017)... 18, 2017 The Philadelphia Pediatric Medical Device Consortium ... devices for children. The Consortium chose those companies ... of $50,000 each. The devices under development are ... a hand-operated rapid blood delivery system for emergency situations and ... ...
Breaking Medicine Technology: