Navigation Links
Hepatic Stellate Cells Found Capable of Tissue Repair

Researchers have found that a cellular receptor involved in triggering cell death is capable of tissue repair and regeneration immediately following liver injury//. This discovery could have implications for early intervention or therapy in liver disease such as cirrhosis or hepatitis.

This research was conducted in mouse models at the University of California, San Diego (UCSD) School of Medicine. Katerina Akassoglou, Ph.D. assistant professor in UCSD's Department of Pharmacology, and colleagues describe the mechanism by which cells associated with liver damage, called hepatic stellate cells (HSCs), are activated by a cell surface molecule called the p75 neurotrophin receptor (p75NTR) to promote repair in the liver.

"Many therapeutics for liver disease target HSCs in order to kill them, but our study in animal models found that their initial activity could actually be protective," said Akassoglou.

When chronic liver injury occurs, cells in the liver begin producing collagen and other proteins that lead to the formation of fibrous tissue and scarring. Akassoglou's team looked at the molecular-cellular interface to discover how tissues respond to deposition of the fibrous protein, fibrin. In studies of a mouse model with excessive fibrin deposition in the liver, the researchers found that p75NTR signaling promotes the initial activation of HSC, which stimulates the proliferation of new hepatic cells to replace those that have been damaged. The effects of p75NTR at late stages of HSC activation and liver disease remain to be determined.

"We were intrigued by the increase of p75NTR expression after liver injury and hypothesized that p75NTR might regulate the progression of liver disease," said Akassoglou. "By identifying p75NTR as the specific molecular link between HSCs and liver regeneration, p75NTR could provide a new therapeutic target for promoting cell regeneration and repair during chronic liver disease or injury."

This discovery suggests the importance of sustaining p75 and early HSC activation – for example, in the case of liver transplantation when regeneration of liver cells is critical.

Source-Eurekalert
PRI
'"/>




Related medicine news :

1. Colon cancer patients benefit from Hepatic Arterial Infusion Therapy
2. Blood Cells Capable of Regenerating Liver
3. White Cells Count Can Predict Heart Attack Death Risk
4. Gene Therapy Destroys Pancreatic Cancer Cells
5. Stem Cells Have Few Mutations
6. Heart may pull Cells from Body to Self-repair
7. Cells critical for asthma development found
8. Vitamin D Wipes out Cancer Cells
9. Bone Marrow Cells Help Heart Attack Patients
10. Islet Cells May Lead to Diabetes CureChildren
11. Stem Cells Found To Offer Promise For Hair Growth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... (PRWEB) , ... March 27, 2017 , ... ... pleased to announce the launch of a months-long rebranding effort. This includes the ... , “Through focus group discussions and market research, we learned that a simple, ...
(Date:3/27/2017)... ... 27, 2017 , ... Harris Communications, Inc., a leading provider of assistive ... to the Deaf Seniors of America Conference, April 4-7 at the Hotel Westin Galleria ... ASL friendly staff from Harris Communications and to try out the newest assistive devices ...
(Date:3/24/2017)... ... March 24, 2017 , ... Vighter established ... same time by providing Prehospital Trauma Life Support (PHTLS) course scholarships to four ... prehospital trauma education developed in cooperation with the American College of Surgeons to ...
(Date:3/24/2017)... , ... March 24, 2017 , ... According to a ... is invalid because it does not obey the rules Congress has directed the CBO ... jobs, which the GOP reform would restore. Yet, it estimates a reduction in employer-based ...
(Date:3/24/2017)... Calif. (PRWEB) , ... March 24, 2017 , ... ... raised over $100,000 for its innovative EcoQube Frame vertical micro-veggies garden on ... instant demand for the product – with nearly 2,000 consumers (and counting) already ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... , March 27, 2017  iCAD (Nasdaq: ICAD), ... solutions and radiation therapy for the early identification ... Tomo Detection received Premarket Approval (PMA) from the ... Detection is a first-of-its-kind, concurrent-read computer aided detection ... the latest innovation available on the PowerLook® Breast ...
(Date:3/27/2017)... 27, 2017  Impax Laboratories, Inc. (NASDAQ: IPXL)today announced ... M. Bisaro as Impax,s President and Chief Executive ... March 27, 2017. Mr. Bisaro will succeed J. ... and Chief Executive Officer since December of 2016. ... pharmaceutical experience, Mr. Bisaro, 56, is an accomplished global ...
(Date:3/27/2017)... March 27, 2017   Genprex, Inc. , a privately held, ... Pham , MD, the Company,s Chief Operating Officer, is scheduled to ... Sachs 5th Annual Cancer BioPartnering & Investment Forum: Tuesday, ... York, NY ... BioCentury 24th Annual Future Leaders in Biotech Industry – ...
Breaking Medicine Technology: