Navigation Links
Hepatic Stellate Cells Found Capable of Tissue Repair

Researchers have found that a cellular receptor involved in triggering cell death is capable of tissue repair and regeneration immediately following liver injury//. This discovery could have implications for early intervention or therapy in liver disease such as cirrhosis or hepatitis.

This research was conducted in mouse models at the University of California, San Diego (UCSD) School of Medicine. Katerina Akassoglou, Ph.D. assistant professor in UCSD's Department of Pharmacology, and colleagues describe the mechanism by which cells associated with liver damage, called hepatic stellate cells (HSCs), are activated by a cell surface molecule called the p75 neurotrophin receptor (p75NTR) to promote repair in the liver.

"Many therapeutics for liver disease target HSCs in order to kill them, but our study in animal models found that their initial activity could actually be protective," said Akassoglou.

When chronic liver injury occurs, cells in the liver begin producing collagen and other proteins that lead to the formation of fibrous tissue and scarring. Akassoglou's team looked at the molecular-cellular interface to discover how tissues respond to deposition of the fibrous protein, fibrin. In studies of a mouse model with excessive fibrin deposition in the liver, the researchers found that p75NTR signaling promotes the initial activation of HSC, which stimulates the proliferation of new hepatic cells to replace those that have been damaged. The effects of p75NTR at late stages of HSC activation and liver disease remain to be determined.

"We were intrigued by the increase of p75NTR expression after liver injury and hypothesized that p75NTR might regulate the progression of liver disease," said Akassoglou. "By identifying p75NTR as the specific molecular link between HSCs and liver regeneration, p75NTR could provide a new therapeutic target for promoting cell regeneration and repair during chronic liver disease or injury."

This discovery suggests the importance of sustaining p75 and early HSC activation – for example, in the case of liver transplantation when regeneration of liver cells is critical.

Source-Eurekalert
PRI
'"/>




Related medicine news :

1. Colon cancer patients benefit from Hepatic Arterial Infusion Therapy
2. Blood Cells Capable of Regenerating Liver
3. White Cells Count Can Predict Heart Attack Death Risk
4. Gene Therapy Destroys Pancreatic Cancer Cells
5. Stem Cells Have Few Mutations
6. Heart may pull Cells from Body to Self-repair
7. Cells critical for asthma development found
8. Vitamin D Wipes out Cancer Cells
9. Bone Marrow Cells Help Heart Attack Patients
10. Islet Cells May Lead to Diabetes CureChildren
11. Stem Cells Found To Offer Promise For Hair Growth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... ... 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing ... their videos a whole new perspective by using the title layers in ProSlice ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016 ... CST on Thursday, July 7, 2016 , , , , ... ) , , , , EXPERT PANELISTS:  , , ... Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar ... The global pharmaceutical industry is witnessing an exceptional ...
(Date:6/23/2016)... 2016  Guerbet announced today that it has been ... Award . One of 12 suppliers to ... its support of Premier members through exceptional local customer ... commitment to lower costs. ... our outstanding customer service from Premier," says Massimo ...
(Date:6/23/2016)... 2016 The Biotechnology industry might ... present great opportunities to investors. Stock-Callers.com assesses the recent ... (NYSE: XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... receive your complimentary trade alerts at: ...
Breaking Medicine Technology: