Navigation Links
Helicobacter pylori Antibiotic Treatment of Peptic Ulcer May not Prevent Gastric lymphomas

Stanford, CA -- Successful eradication of Helicobacter may not prevent future aggressive gastric lymphoma since resting B cells are left behind. This was reported by Research led by Dr. Anne Mueller at Stanford University // School of Medicine.

The paper by Mueller et al., "The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of Helicobacter-induced MALT lymphoma," appears in the September issue of The American Journal of Pathology.

Helicobacter pylori, a spiral bacterium of the stomach, infects more than half of the world's population. It is now widely accepted that, aside from gastritis and ulcers, H. pylori is also a causative agent of gastric lymphoma, specifically gastric B cell lymphoma of mucosa-associated lymphoid tissue (MALT). While antibiotic treatment eradicates the bacteria and promotes tumor regression, the effects of re-infection on disease are more severe.

Dr. Mueller's group used a mouse model of Helicobacter-induced MALT lymphoma that employs H. felis to mimic human disease in the mouse. Mice were infected with H. felis and maintained for 18 months before being assigned to one of three treatment groups: 1) no treatment (primarily infected), 2) antibiotic therapy to eradicate bacteria, or 3) antibiotic therapy followed by re-infection.

As expected, low-grade MALT lymphoma occurred in 35% of all infected animals. However, frank MALT lymphoma was more prevalent in re-infected animals (44%) than in primarily infected animals (25%). The significance of the described work is that gastric lymphoma progresses more rapidly upon secondary infection. Because resting B cells are left behind following antibiotic treatment, re-infection by H. pylori promotes the existing B cells to progress quickly into tumors. Therefore, it is important that treated patients be carefully monitored for H. pylori re-infection.

Ref: Mueller O 'Rourke J, Chu P, Chu A, Dixon MF, Bouley DM, Lee A , Falkow S: The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of Helicobacter-induced MALT lymphoma. Am J Pathol 2005, 167:797-812

Research was supported by the National Institutes of Health (US), the Emmy-Noether-Program of the Deutsche Forschungsgemeinschaft (Germany), and J National Health and Medical Research Council (Australia).

Contact: Audra Cox acox@asip.org 301-634-7409 American Journal of Pathology

(Sourece: www.eurekalert.org)

Further Information on Medindia on H.Pylori:

H.Pylori testing recommended in patients with peptic ulcer: Researchers in the United States have found that the practice of testing and treating H.Pylori has steadily increased over the past 14 years. However, they suggested that patients with confirmed peptic ulcer disease should be tested for Helicobacter Pylori(H.Pylori) infection rather than receiving treatment for the infection as a matter of course. Testing was a more appropriate option than empiric treatment in patients with peptic ulcer disease, as the prevalence of H.Pylori was found to be only 36 percent.

Click here to read more:

http://www.medindia.net/news/view_news_main.asp?t=gn&x=1834
'"/>




Related medicine news :

1. Dietary cure for fighting Helicobacter pylori
2. Helicobacter pylori effectively killed by Sodium nitrite
3. Evidence supporting H.pylori eradication
4. Dietary cure for fighting Helicobacter pylori
5. Helicobacter pylori effectively killed by Sodium nitrite
6. Receptor for H.pylori Identified in Stomach
7. Antibiotics Dangerous for Diarrhoea in Children Caused by E.Coli
8. Antibiotics Helps Autism
9. Antibiotics losing their power against acne
10. Antibiotic induces liver damage in children with E.COLI infections.
11. Antibiotics help heart patients
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/17/2017)... ... February 17, 2017 , ... Program will ... Trinity Health and the U.S. Soccer Foundation announced today that they have awarded ... Soccer for Success, the Foundation’s soccer mentoring program, teaches kids the fundamentals of ...
(Date:2/17/2017)... ... February 17, 2017 , ... PrideStaff, a national staffing ... named to Staffing Industry Analysts' 2017 "Staffing 100 North America" list. , ... notable contributions to the staffing industry over the last twelve months. Industry insiders ...
(Date:2/17/2017)... CO (PRWEB) , ... February 17, 2017 , ... Top ... annual International Healing NET Foundation Summit from February 21 - 23 in Beaver Creek, ... Foundation (HNF). This marks the Summit’s second year in Beaver Creek, hosting over 60 ...
(Date:2/16/2017)... York, New York (PRWEB) , ... February 17, ... ... work and determination. After what took over 10 years of research, development and ... technology, NTX Technology™. NTX Technology™ is a patented compound of FDA approved ingredients ...
(Date:2/16/2017)... ... February 17, 2017 , ... The Price Agency, a ... and entrepreneurs in the Birmingham area, is announcing an ongoing charity event to ... her medically challenged son, Anius. , Anius is medically complex with diagnoses consisting ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... Pa. , Feb. 16, 2017 Absorption ... biologics, and medical devices, is pleased to announce that ... has been selected as a winner of the 2017 ... SmartCEO Magazine and recognizes driven executives for their ... work ethic. The awards ceremony and celebration is on ...
(Date:2/16/2017)... 2017  Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... announced that executive management will participate in the RBC ... 22-23, 2017. Adrian Adams , Chief Executive Officer, ... p.m. local time on Wednesday, February 22, 2017. ... event may be accessed from the Investors section of ...
(Date:2/16/2017)... YORK , Feb. 16, 2017 Summary ... agreements entered into by the worlds leading healthcare companies. ... Description The Global Allergy ... to partnering deals and agreements entered into by the world,s leading ... - Top deals by value - Deals listed by company ...
Breaking Medicine Technology: