Navigation Links
Heart Drug has grave side effects

According to researchers, a drug commonly used for short-term treatment of worsening heart failure in hospitalized patients may cause dangerously low blood pressure and abnormal heart rhythms. //The findings suggest that the drug, milrinone, should be reserved for patients who do not respond to other medication, said Dr. Mihai Gheorghiade of Northwestern University.

According to Gheorghiade, the study is one of the few to compare a placebo with a drug for worsening heart failure, a condition that sends about 1 million Americans to the hospital each year. Despite the poor results, it shows that such studies can and should be done on similar drugs.

An accompanying editorial says the use of other drugs commonly used in worsening heart failure, dopamine and dobutamine, should be reconsidered given the milrinone findings, since all three drugs work similarly to strengthen the heartbeat.

Heart failure, in which the heart gradually loses its ability to pump blood efficiently, affects nearly 5 million Americans. The condition may be chronic, but patients can develop severe attacks of breathing difficulty that require hospitalization.

Dr. Ann Bolger, an American Heart Association spokeswoman, said patients studied were generally less sick than those who typically would be given milrinone. The study shows ``there really isn't any advantage'' to giving milrinone to patients who are not acutely ill, Bolger said.

Sanofi-Synthelabo Inc., which markets milrinone in the United States, funded the study. The company's Web site warns that the drug may cause irregular heartbeats, and says milrinone should be stopped if blood pressure falls too low. It also says that the drug may not be safe or effective when given for longer than 48 hours, and that long-term oral treatment has been linked with an increased risk of hospitalization and death.

Another JAMA study shows favorable results for a newer drug called Natrecor, app roved last year for worsening heart failure. Known chemically as nesiritide, the drug improved breathing and blood flow, and appeared to work more quickly than intravenous nitroglycerin.

Dr. Michael Cuffe, a Duke University cardiologist who helped lead the milrinone study, said the research looked at how patients fared over the longer term, unlike the research that led to government approval of the drug. The study involved 949 patients given either a dummy drug or a 48-hour milrinone infusion.


'"/>




Related medicine news :

1. One in Three Heart Attack Patients Have No Chest Pains
2. Epileptic Seizures Can Be Due to Heart Problem
3. Bypass Heart Surgery Performed Without General Anesthesia
4. New CPR Guidelines issued by Heart Association
5. White Cells Count Can Predict Heart Attack Death Risk
6. Vitamins-The answer to Heart Disease?
7. Fight Heart disease and Pain with Meditation
8. Heart disease in the newborn is related to maternal malnutrition
9. New drug to treat Heart Attack and damaged tissue
10. Heart disease threat starts early in life for Diabetics
11. Mechanical Heart
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/25/2017)... ... July 25, 2017 , ... Therachat , a smart ... and providing demos of its smart journaling platform at the 125th American Psychological ... D.C. from August 3-6, 2017. , The APA Annual Convention is one of ...
(Date:7/25/2017)... WI (PRWEB) , ... July 25, 2017 , ... ... Aloria Health, as medical director. Dr. Negrette has more than a decade of ... She has worked closely with individuals fighting addictions, eating disorders, psychotic and manic ...
(Date:7/25/2017)... TX (PRWEB) , ... July 25, 2017 , ... SignatureCare ... emergencies in the Austin, TX area 24 Hours a day. , The ... Austin, TX. , “We’ve been open four months now and things are running ...
(Date:7/24/2017)... ... 2017 , ... Cheerag D. Upadhyaya , M.D., M.Sc., FAANS has been ... (SLMBNI), part of Saint Luke’s Health System . Dr. Upadhyaya has served in ... M.Sc., FAANS joins Stanley P. Fisher, M.D., who has served as medical ...
(Date:7/24/2017)... ... July 24, 2017 , ... BayMark Health Services ... Health Services Administration’s (SAMHSA) State Targeted Response to the Opioid Crisis program. ... will facilitate the development of a hub and spoke model for opioid treatment ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... , July 13, 2017 RK Logistics Group, ... of Pharmacy certification for its Fremont, CA ... solutions in the Tri-Valley and San Jose ... City of Fremont , with its Fremont Innovation ... to provide such a powerful resource to the hundreds of ...
(Date:7/12/2017)... INDIANAPOLIS , July 12, 2017  Eli Lilly and ... settlement agreement with generic companies to resolve pending patent litigation ... Virginia regarding the Cialis ® ... expire on April 26, 2020. As part of the agreement, ... on September 27, 2018. "The unit dose patent ...
(Date:7/11/2017)... 2017  The global market for liquid biopsy diagnostic ... million in 2016.  Although in early stages, the global ... particular as a result of the gradual shift towards ... introduction of a significant number of new liquid biopsy ... tumor biomarkers to guide treatment decisions. ...
Breaking Medicine Technology: