Navigation Links
Healing Bone With Stem Cells

Implantable materials that grab stem cells and spur their growth and survival could improve bone-healing surgeries. Linda Griffith and her colleagues// at MIT have created a new tissue-engineering material that could help cells survive the harsh transplant environment--a key step in cell-transplant therapies. Scientists are now testing the material in animals to see how well it can help heal fractures.

"Creating instructional biomaterials like this is an entirely new way of thinking about what could be put in the human body," says Richard Lee, a cardiologist and scientist at Harvard Medical School and Brigham and Women's Hospital, in Boston. "It could become an important component of regenerative medicine."

Patients with severe fractures that can't heal on their own typically undergo a painful bone biopsy in which a bone fragment is removed from the hip and then transplanted onto the site of the wound. But improvements to an alternative procedure developed in the past few years could soon make this process obsolete. In the procedure, orthopedic surgeons withdraw bone marrow (which contains bone-forming stem cells) from the patient and then process and transplant those cells onto the fracture without the need for bone biopsy.

Some 40,000 people have already undergone the procedure, but scientists say the technique could be improved by increasing the survival and proliferation of the transplanted cells. "Cells experience a very harsh environment when first transplanted," says George Muschler, an orthopedic surgeon at the Cleveland Clinic, in Ohio, who pioneered development of the bone-marrow transplant technique. "There is little oxygen, it's very acidic, and there are inflammatory factors that might trigger cell death." In addition, only about one in every 20,000 bone-marrow cells is a bone-producing stem cell, making survival of those cells particularly critical.

A new material that stops cell-death signals in t heir tracks could help. Over the past decade, Griffith and her colleagues have developed materials called comb scaffolds that have been employed for a variety of tissue-engineering uses, such as growing new blood vessels. The comb consists of a Plexiglas backbone studded with molecular tethers that can hold different protein growth factors at their tips. In their latest round of experiments, the researchers modified the scaffold to hold epidermal growth factor (EGF) molecules, a protein that plays a role in growth and differentiation of many cells, including stem cells. According to research published earlier this year in the journal Stem Cells, adult stem cells grown on the EGF scaffolds were better able to survive. And preliminary evidence suggests that the scaffold also boosts cell proliferation, potentially increasing the number of cells available to make new bone after transplantation.

Muschler, an orthopedic surgeon and Griffith's collaborator, is now testing the scaffold in animal models to see how well it heals fractures. And Griffith is planning additional experiments with human stem cells to explore how different proteins on the scaffold might encourage these cells to differentiate into bone. "We want to figure out step by step how to use marrow more effectively in the clinic," she says. Their ultimate goal is to be able to extract bone marrow from a patient and, while still in the operating room, filter the extract through a specially designed scaffold that preferentially grabs bone-forming stem cells and boosts their growth and survival. The cells can then be directly implanted into the patient.

"The field is just beginning," says Lee. "It will be exciting to see how much ability this gives us to change materials, and how they react with the body."

Source-Bio-Bio Technology
'"/>




Related medicine news :

1. Healing a painful neck
2. Healing environment aids mental problem
3. Blocking Pain Found To Slow Down The Healing Process
4. Energy Therapy For Quicker Healing
5. Link between Faith, Health and Healing
6. Psychological Stress Delays Wound Healing
7. Adult Stem Cells From Fat Tissues For Healing
8. Wound Healing Found To Be Slower In Couples Who Fight Often
9. Does Magnet Therapy Posses Healing Powers?
10. Art As A Healing Tool In Cancer
11. Dance Therapy For Healing Nepals Battered Women
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... ... December 02, 2016 , ... ‘Tis the season for giving! Today, 20 creative ... National Family Partnership and the Drug Enforcement Administration as part of the National Red ... 10 winning schools who decorated their campuses with this year’s Red Ribbon Week theme: ...
(Date:11/30/2016)... , ... November 30, 2016 , ... ... they now offer a comprehensive in-house dental plan for all patients. Understanding that ... a plan that gives patients a number of perks, including discounts on many ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... Deloitte Wisconsin 75, an annual ranking and recognition of the largest closely held ... list, having ranked from 2008-2016. In addition, Standard Process was awarded the Talent ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For ... announced the opening of a new residential mental health treatment program in Chino ... issues such as severe anxiety, depression, bi-polar disorder, and other related issues. , ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... and stylish design wanted by today’s consumers at an affordable price, is now ... says the new watch is “a game changer” when it comes to the ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 bioLytical Laboratories, un líder mundial en test rápidos ... HIV Self Test , a los miembros de la Kenya Pharmaceutical Association. ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical fue invitada por la ...
(Date:12/2/2016)... GARDENS, N.Y. , Dec. 2, 2016  LifeVac, ... will be included in the Emergency Response Training and ... are very excited to have LifeVac become part of ... Lih , Founder and CEO of LifeVac. "Having an ... LifeVac safely and effectively will help leverage our efforts ...
(Date:12/2/2016)... India , December 2, 2016 ... report "In Vitro Diagnostics/IVD Market by Product (Instruments, ... Hematology), Application (Diabetes, Oncology, Cardiology, Nephrology, Infectious Diseases) ... global market is valued at USD 60.22 Billion ... at a CAGR of 5.5% during the forecast ...
Breaking Medicine Technology: