Navigation Links
HIV treatment interruption may enhance the risk of brain injury

Although the current therapeutic regimens are effective in suppressing HIV infection, they do not eradicate it, and prolonged treatment may be complicated by development of drug resistance and an array of side effects. Despite // continued concerns over the safety of interrupting therapy, a large proportion of subjects in clinical practice interrupt therapy for reasons related to drug toxicity, treatment fatigue and/or drug costs.

New research at the Sahlgrenska University, Sweden, and San Francisco General Hospital, CA, USA, suggests that resurgence of active HIV replication may result in injury of the central nervous system (CNS).

The neurofilaments are major structural components of the neuronal cytoskeleton, particularly concentrated in axons and have a major role to play in the maturation of axons and the maintenance of axonal integrity. Increased concentrations of the light chain of the neurofilament protein (NFL) in the cerebrospinal fluid (CSF) can serve as a sensitive indicator of CNS injury.

In the study, published in the second volume of AIDS Research and Therapy, 2005, the researchers measured NFL levels in HIV-infected subjects interrupting therapy in order to assess whether interrupting antiretroviral treatment of HIV infection might have a deleterious effect on the CNS. NFL is a sensitive marker of axonal injury, which in the present setting seems to disclose subclinical injury. Three of a total of eight subjects studied after stopping antiretroviral therapy showed substantial increase in CSF NFL, thereby indicating brain injury in this setting.

This study, while raising the concern that treatment interruption may enhance the risk of brain injury, also suggests that once started, continued treatment might prevent subclinical brain damage.
'"/>




Page: 1

Related medicine news :

1. Thyroid hormone treatment hastens recovery after cardiac surgery
2. Feeding channel created by malaria parasite - a new target for malaria treatments
3. Now umbilical cord helps in stroke treatment.
4. Now AIDS treatment comes dirt-cheap
5. Breast cancer treatment to be determined by gene test
6. Hemopurifier may revolutionise AIDS treatment
7. New drug helps boost cancer treatment
8. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
9. Experimental treatment for Ebola Virus Shows promising results in mice
10. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
11. New dimension in the treatment of female sexual dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2017)... OH (PRWEB) , ... May 24, 2017 , ... Dr. ... and comfortable ClearCorrect orthodontics, with or without a referral. Dr. Kejriwal understands ... why she offers convenient, clear braces in Cincinnati, OH. Patients no longer need to ...
(Date:5/24/2017)... ... May 24, 2017 , ... STATEMENT OPPOSING PRESIDENT DONALD ... to Donald Trump’s budget, “A New Foundation for American Greatness—President's Budget FY 2018,” ... poor, marginalizes underserved populations, undermines productivity, and destroys the social safety net needed ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... II of the HP3 (High-Performance Periodontal Practice) continuing education (CE) series. As a ... advancements in his field by attending numerous CE courses each year. His recent ...
(Date:5/24/2017)... ... ... Medic CE , a Career Step company, is sponsoring a live, 1-hour ... Journal of Emergency Medical Services (JEMS). The free webinar, to be held on Wednesday, ... Duckworth, LP, a career fire captain as well as founder and director of the ...
(Date:5/24/2017)... ... ... If you are thinking of a visit to San Francisco , fall is a ... time to visit. , Business Architecture Associates is pleased to offer 5 days of training ... 4-½ day package for individuals, and as 4-½ day corporate package for up to 3 ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... May 9, 2017  Oramed Pharmaceuticals Inc. (NASDAQ: ... clinical-stage pharmaceutical company focused on the development of ... Canadian Intellectual Property Office has granted Oramed a ... of Exenatide". The patent covers Oramed,s invention of ... GLP-1 is an incretin hormone that stimulates the ...
(Date:5/8/2017)... May 8, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO)., ... ("WRB"), a health care service center company based ... WRB specializes in relationship management programs for leading pharmaceutical ... WRB will join Envoy Health ... services for manufacturers, biotech firms, and other service companies. ...
(Date:5/6/2017)... SKANEATELES FALLS, N.Y. , May 5, 2017 /PRNewswire/ ... expansion that will add approximately 100,000 square feet to ... announced in September 2016 its commitment to bring more ... York , where Welch Allyn has maintained a ... facility will help accommodate these new positions, a large ...
Breaking Medicine Technology: