Navigation Links
HIV treatment interruption may enhance the risk of brain injury

Although the current therapeutic regimens are effective in suppressing HIV infection, they do not eradicate it, and prolonged treatment may be complicated by development of drug resistance and an array of side effects. Despite // continued concerns over the safety of interrupting therapy, a large proportion of subjects in clinical practice interrupt therapy for reasons related to drug toxicity, treatment fatigue and/or drug costs.

New research at the Sahlgrenska University, Sweden, and San Francisco General Hospital, CA, USA, suggests that resurgence of active HIV replication may result in injury of the central nervous system (CNS).

The neurofilaments are major structural components of the neuronal cytoskeleton, particularly concentrated in axons and have a major role to play in the maturation of axons and the maintenance of axonal integrity. Increased concentrations of the light chain of the neurofilament protein (NFL) in the cerebrospinal fluid (CSF) can serve as a sensitive indicator of CNS injury.

In the study, published in the second volume of AIDS Research and Therapy, 2005, the researchers measured NFL levels in HIV-infected subjects interrupting therapy in order to assess whether interrupting antiretroviral treatment of HIV infection might have a deleterious effect on the CNS. NFL is a sensitive marker of axonal injury, which in the present setting seems to disclose subclinical injury. Three of a total of eight subjects studied after stopping antiretroviral therapy showed substantial increase in CSF NFL, thereby indicating brain injury in this setting.

This study, while raising the concern that treatment interruption may enhance the risk of brain injury, also suggests that once started, continued treatment might prevent subclinical brain damage.
'"/>




Page: 1

Related medicine news :

1. Thyroid hormone treatment hastens recovery after cardiac surgery
2. Feeding channel created by malaria parasite - a new target for malaria treatments
3. Now umbilical cord helps in stroke treatment.
4. Now AIDS treatment comes dirt-cheap
5. Breast cancer treatment to be determined by gene test
6. Hemopurifier may revolutionise AIDS treatment
7. New drug helps boost cancer treatment
8. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
9. Experimental treatment for Ebola Virus Shows promising results in mice
10. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
11. New dimension in the treatment of female sexual dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a ... health care, have expanded their existing home health joint venture through an agreement, ... been operating a joint venture home health company with Asante, delivering clinically integrated ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United States, ... In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the ... have extremely low property-tax rates, which contributes to the relatively lower cost of ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
(Date:9/23/2017)... 22, 2017 Janssen Biotech, Inc. (Janssen) announced ... from the U.S. Food and Drug Administration (FDA) for ... for the treatment of moderately to severely active rheumatoid ... data are needed to further evaluate the safety of ... RA. "We ...
Breaking Medicine Technology: