Scientists at the Dana-Farber Cancer Institute have identified a protein that essentially blocks HIV replication, in monkey cells. Humans have a similar protein, although it is not as effective at stopping HIV, say the researchers whose work //is published in this week's issue of Nature. The team, headed by Joseph Sodroski, is supported by the NIH's National Institute of Allergy and Infectious Diseases (NIAID).

"Identification of this HIV-blocking factor opens many new avenues for intervening in the early stage of HIV infection, before the virus can gain a sronghold," says NIAID director Anthony Fauci, "The discovery also gives us critical insights about viral uncoating, a little understood step in the viral lifecycle. Basic discoveries like this provide the scientific springboard to future improvements in therapies for HIV disease."


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