The first published report of the HIV eradication potential of a bone marrow transplant in an individual on highly active antiretroviral therapy (HAART) has concluded that// eradication is unlikely utilising this method.
Currently available anti-HIV drugs may be able to reduce HIV to 'undetectable' levels in the blood, but they cannot remove HIV's genes that are integrated in the DNA of our own cells. Although scientists have been working on eradicating HIV from the body for more than two decades, and knowledge is increasing incrementally, their work has ultimately been disappointing.
One possible avenue considered promising in the pre-HAART era was bone marrow transplantation. Between 1982 and 1996, reports of over 30 bone marrow transplants in HIV-positive individuals with advanced disease were published. In some cases, individuals required chemotherapy and radiation and subsequent bone marrow transplants for non-Hodgkin lymphoma. In other cases researchers actively enrolled individuals with AIDS at a time when there appeared to be no other options and replaced their bone marrow with those from healthy transplanted donors in order to attempt to repopulate the individual’s immune system with healthy, HIV-free blood cells.
Although most died due to HIV- or transplant-related complications soon after the procedures, two individuals were found to have undetectable HIV RNA and DNA levels in the weeks and months following the procedures. A review of these reports, written in 1997, and published in 1999, suggested that bone marrow transplantation offered the tantalising possibility of a “cure” for HIV. It suggested that utilising more potent anti-HIV drugs alongside pre-transplant chemo- or radiation therapy might provide a more satisfactory outcome, since AZT monotherapy had been used in most cases (Huzicka 1999).
Since then, however, other less toxic and/or invasive methods of HIV eradication have been attempted, andPage: 1 2 3 Related medicine news :1
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