Navigation Links
HIV Drug Resistance can Be Identified by Genome Sequencing

Undetectable drug-resistant forms of HIV have been identified by Yale School of Medicine researcher Michael Kozal, M.D., using an innovative genome sequencing technology that quickly detects rare viral mutations.

Kozal, associate professor of medicine at Yale and senior author of the retrospective study that used samples from an earlier clinical trial, presented the findings today at the 16th International HIV Drug Resistance Workshop in Barbados.

We found that the fraction of HIV patients that harbored resistance mutations is at least twice as high as previously thought, said Kozal, who also directs the HIV Program at the VA Connecticut Healthcare System. These low frequency resistant viral strains are not detectable by current resistance testing methods used in the clinic.

While HIV treatment has been largely successful, with dramatic increases in survival over the last decade, a significant number of patients develop drug resistance shortly after treatment begins. This study was designed to determine if patients that fail therapy early were initially infected with drug resistant HIV strains.

Kozal and his team examined samples from 258 subjects of the FIRST study, a large multi-center five-year U.S. trial comparing three different approaches to antiretroviral therapy. The study evaluated the long-term clinical and virologic effects of three initial antiretroviral drug regimens for treatment-nave HIV infected persons.

Kozal and colleagues used the Genome Sequencer system and Ultra Deep Sequencing technology, which was developed by 454 Life Sciences, to detect additional low abundant resistant variants and to predict the failure of antiretroviral therapy.


Kozal said that current genotypic resistance technology available to clinicians is limited to detecting resistance mutations that are present at levels of approximately 20 percent or greater in the circulating viral population in a patient. Therefore, the current technology used in the clinic may miss many low-level resistant HIV strains that can grow rapidly under drug selection pressure and lead to therapy failure.

This study clearly shows that resistance HIV strains present at the one percent level can lead to premature failure of therapy, said Kozal. It is our hope that in the future, clinicians can use this knowledge to better choose antiretroviral drug combinations that have the ability to suppress these resistant HIV strains, leading to better clinical responses in patients.

It is estimated that 22 million people have died from AIDS and over 42 million people are living with HIV/AIDS worldwide. In the U.S. alone, 40,000 new infections occur each year.


'"/>




Related medicine news :

1. Link between birth weight and Insulin Resistance
2. Easier Methods Required to Screen Insulin Resistance
3. Easier Methods Required to Screen Insulin Resistance
4. Insulin Resistance Linked To Difference In Gender
5. Adopting Easier Methods To Screen Insulin Resistance
6. Drug Resistance Questioned in Patients With Chronic Sinusitis
7. Understanding Insulin Resistance
8. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
9. Junk Food Causes High Level Of Insulin Resistance In Children
10. Ways Of Tackling Antibiotic Resistance
11. Flu-Drugs Are Causing Resistance Across The World
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2017)... GREENVILLE, SC (PRWEB) , ... January 23, 2017 ... ... which is the premiere organization in North America for the scientific development, healthcare ... its 2017 Annual Scientific Session, and its 2017 AAT Member Certification Qualification Courses ...
(Date:1/23/2017)... ... January 23, 2017 , ... Steviva Ingredients, makers of all-natural ... USDA National Organic Program (NOP) for its Portland SQF Level 2 manufacturing facility. ... and handling systems to complement our current rigorous food-safety management systems,” said Yishu ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... general gynecological care and gynecological services for women of all ages. ... for a wide variety of reproductive services from routine health screenings to diagnosing ...
(Date:1/23/2017)... ... ... “Life Under Blankets”: an entrancing story about one woman's travels through the ... creation of published author, Kimberly Mitchell, who earned her bachelor’s degree in English education ... a master’s degree in education in the field of curriculum and instruction. Kimberly’s passion ...
(Date:1/22/2017)... Boca Raton, FL (PRWEB) , ... January 22, 2017 , ... ... products to customers across the world, recently met with big-name retail buyers at the ... strong scientific evidence of efficacy and uses the utmost safety standards in all of ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... N.Y. , Jan. 23, 2017 LifeVac, ... from a blocked airway and prevented choking deaths, welcomes ... awareness advocate to the LifeVac team as Official Spokesperson. ... Steve join the LifeVac team," said Arthur Lih ... positioned to represent LifeVac and his mission to raise ...
(Date:1/23/2017)... , Jan 23, 2017 Research and Markets has ... & Trends - Product - Forecast to 2025" report to their ... Report Highlights: ... future market trends to identify the investment opportunities Market ... Key market trends across the business segments, Regions and Countries ...
(Date:1/23/2017)... January 23, 2017 Stock-Callers.com today presents ... (NASDAQ: CPRX ), Sophiris Bio Inc. (NASDAQ: ... ), and Agile Therapeutics Inc. (NASDAQ: AGRX ). ... somewhat lower in late trade on Friday, January 20 th ... 0.3%, while shares of health care companies in the S&P ...
Breaking Medicine Technology: