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HHS Buys Next Generation Smallpox Vaccine

ith a two-dose immunization schedule) of MVA vaccine purchased under this contract would be available to them.

This is the first BioShield contract to allow two types of advance (pre-delivery) payments -- one under the Project BioShield Act of 2004, and the other under the Pandemic and All-Hazards Preparedness Act of 2006. The contract also is the first under the Pandemic and All-Hazards Preparedness Act.

Under BioShield, the company can get an advance payment based on a determination that it is necessary to the success of the product. Under the Pandemic and All-Hazards Preparedness Act, the company can get payments as it reaches certain milestones in product development, before delivery of product to the Strategic National Stockpile.

"The use of these new authorities under the Pandemic and All-Hazards Preparedness Act further demonstrates our commitment to building improved partnerships with industry," Secretary Leavitt said.

This procurement builds upon the MVA smallpox vaccine research and development efforts initiated by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.

Through research funded by NIAID in 2003, scientists successfully performed small-scale manufacturing of the MVA vaccines and conducted Phase I clinical trials in healthy volunteers. These early development studies showed that MVA vaccine was safe and was able to stimulate an immune response in healthy volunteers. Large-scale manufacturing of the vaccine was subsequently performed. Several Phase II clinical studies are now either under way or planned, in healthy individuals and in individuals with weakened immune systems. The purpose of these studies is to further assess the safety of the vaccine, and also to begin to assess how effective the vaccine will be based on the immune responses generated.

The last case of smallpox occurred in the United States in 1949
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