Navigation Links
Growth Factors Help Neurons to Reach Their Correct Destination

says. Skeletal muscle consists of thousands of muscle fibers, each controlled by one motor neuron whose cell body lies in the brain or spinal cord.

Connections between muscle and nerve cells are established embryonically when newborn neurons extend axons to ‘wire’ the appropriate muscle fiber. The wiring process is highly orchestrated –each motor neuron has already pledged allegiance to a particular muscle fiber before it reaches out to connect with its predetermined partner. But until now, scientists could only speculate how the invisible bond was formed. ‘The question was how these motor neurons know where to go,’ says Pfaff. ‘It would be a disaster if you wanted to move your arm and instead bent your back.’ Earlier studies suggested that muscles lining the spine sent out chemical cues as a siren song for specific motor neurons known as MMCm cells. But when attempts to identify the enticing substance failed, many started to doubt its existence.

After screening numerous candidates, the Pfaff team found not only that FGF is expressed in target muscle, but that FGF ‘sensors,’ known as FGF receptors, are expressed in MMCm motor neurons. Furthermore, MMCm axons could not ‘hear’ their muscle partner's call and failed to reach their destination in mouse mutants lacking the sensor molecule. Finally, using mice engineered to express a fluorescent protein in MMCm neurons, the investigators demonstrated that only the glowing neurons extended axons in the direction of target cells expressing FGF. ‘After a lot of hard work, we narrowed it down to FGFs and showed that they were indeed the long sought-after mysterious substance,’ says Pfaff. Neural stem cells can now be coaxed to develop into motor neurons in a test tube.

In that artificial environment, explains Pfaff, ‘Most external cues that guide immature motor neurons during embryonic development will be missing.’ Hence the need to identify axon guidance factors. He continues, ‘It is not enoug
'"/>




Page: 1 2 3

Related medicine news :

1. Anti-Cancer Drug Restores Normal Cell Growth
2. Low-dose Growth Hormone (GH) with diet and exercise may help weight loss
3. Human Growth Hormone Found To be Dangerous For Human Use
4. Stem Cells Found To Offer Promise For Hair Growth
5. Fish Found To Improve Fetal Growth
6. Growth Patterns In Childhood Could Predict Breast Cancer Later In Life
7. Stopping The Growth Of Viruses
8. Stopping The Growth Of Viruses
9. Turmeric Found To Slow Down Melanoma Growth
10. Protein acts as "Master Switch" that cuts off cells Cancer-Growth machinery
11. Record Growth Of Soya-Based Dairy Alternatives Over The Past Year In European Markets
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Growth Factors Help Neurons Reach Their Correct Destination

(Date:1/22/2015)... Woodloch Pines, an all-inclusive family resort ... TripAdvisor as the number one best large hotel for families ... world for their annual Travelers’ Choice Awards. , TripAdvisor ... website is home to millions of unbiased and honest traveler ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many ... it on Facebook, Twitter, and Pinterest. The fans will have ... a lottery every week. , Moreover, the company has extended ... Angelweddingdress homepage for more information. , Angelweddingdress ...
(Date:1/22/2015)... TX (PRWEB) January 22, 2015 A ... issue of experience and person-centeredness in the long-term care ... towards action across the continuum. The paper, “The Power ... Continuum,” engages perspectives and practices of the patient, resident ...
(Date:1/22/2015)... 2015 Joan Lunden, award-winning American journalist, ... the upcoming 32nd Annual Miami Breast Cancer Conference ... Resource®, LLC (PER®) , shares that “a fast-growing, virulent” ... if she had not followed up her clean mammogram ...
(Date:1/22/2015)... Four years since the release of their debut recording Love ... of Avasa & Matthew Love – the duo are pleased to ... through White Swan Records on February 24, 2015. , THE ROAD ... available to all of us to walk out of the mire ...
Breaking Medicine News(10 mins):Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... health, social skills in the process, experts say , FRIDAY, ... mean days spent at the beach or lake, afternoon bike ... is more likely to be lived in the not-so-great indoors, ... "human" contact. , The indoor child phenomenon concerns health experts ...
... A twice weekly hip strengthening regimen performed for six ... some cases eliminating -- knee pain referred to as ... study by Tracy Dierks, assistant professor in the Department ... based on the theory that stronger hips would correct ...
... ... better ROI , ... Rochester, NY and Piscataway NJ (PRWEB) June 4, 2010 -- UniteU Technologies, Inc., a ... optimizing solutions for online stores, are announcing the availability of Filtered Navigation Search Express ...
... Theurer Cancer Center at Hackensack University Medical Center announced ... the American Society of Clinical Oncology (ASCO) annual meeting ... Research highlights include a comparison of first-line treatments for ... of a new genetically engineered cancer therapy, and the ...
... Blood Institute (NHLBI) has stopped a clinical trial evaluating a ... children with sickle cell anemia and iron overload because of ... than the existing treatment. The 26-site trial, Stroke ... between the ages of 5 and 18 who had already ...
... role in the aging process appears to play a role ... according to researchers from the Center for Stem Cell Biology ... Jefferson University. In the study, published online in ... protein interaction that controls the silencing of Oct4, a key ...
Cached Medicine News:Health News:Move Childhood Back Outdoors This Summer 2Health News:Move Childhood Back Outdoors This Summer 3Health News:Hip exercises found effective at reducing, eliminating common knee pain in runners 2Health News:UniteU and Celebros Launch Dynamic Cross-Sell and New Version of Filtered Navigation Search 2Health News:UniteU and Celebros Launch Dynamic Cross-Sell and New Version of Filtered Navigation Search 3Health News:John Theurer Cancer Center experts present new cancer research at ASCO Annual Meeting 2Health News:John Theurer Cancer Center experts present new cancer research at ASCO Annual Meeting 3Health News:John Theurer Cancer Center experts present new cancer research at ASCO Annual Meeting 4Health News:Stroke prevention study in children with sickle cell anemia, iron overload stopped early 2Health News:Stroke prevention study in children with sickle cell anemia, iron overload stopped early 3Health News:Gene related to aging plays role in stem cell differentiation 2
(Date:1/23/2015)... , Jan. 23, 2015  Today the U.S. Food ... Bexsero® for the prevention of serogroup B meningococcal ... and Pfizer,s vaccine Trumenba®, which received FDA approval in ... this devastating disease. "I have heard ...
(Date:1/23/2015)... analysis of Centers for Medicare and Medicaid Services, (CMS) ... percent of seniors chose lower-cost preferred pharmacy plans that ... The findings were released by Drug Channels . ... of Medicare Part D," said Pharmaceutical Care Management Association ...
(Date:1/23/2015)... , Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ( ... of directors of Advaxis, Inc. ("Advaxis" or the "Company") ... has breached its fiduciary duties to shareholders. ... an investing website reporting that Advaxis had misrepresented the ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2
... Cord Blood America, Inc . ( http://www.cordblood-america.com ) (OTC ... stem cell preservation company focused on bringing the ... internationally, announced today a Special Meeting of its shareholders on ... reverse stock split of one share for each 500 outstanding ...
... Calif., Feb. 10, 2011 PRO-DEX, INC. (Nasdaq: ... quarter and six months ended December 31, 2010. ... 8% to $6.2 million from $5.7 million for the corresponding ... the Company,s medical device products to its largest customer, and ...
Cached Medicine Technology:Cord Blood America Announces Special Shareholder Meeting 2Cord Blood America Announces Special Shareholder Meeting 3Pro-Dex, Inc. Announces Fiscal Second Quarter and Six Month Results 2Pro-Dex, Inc. Announces Fiscal Second Quarter and Six Month Results 3Pro-Dex, Inc. Announces Fiscal Second Quarter and Six Month Results 4Pro-Dex, Inc. Announces Fiscal Second Quarter and Six Month Results 5Pro-Dex, Inc. Announces Fiscal Second Quarter and Six Month Results 6Pro-Dex, Inc. Announces Fiscal Second Quarter and Six Month Results 7
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: