Navigation Links
Growth Factor Aids in Regeneration of Heart Blood Vessel

The latest modality in the treatment of coronary artery disease is to induce hearts to regenerate blood vessels to bypass clogged arteries and damaged tissue. // Unfortunately, clinical trials, which were carried out for two important blood vessel growth factors, fibroblast growth factor- 2 (FGF2) and vascular endothelial growth factor (VEGF), have not yielded sterling outcomes.

Now researchers at Washington University School of Medicine in St. Louis have investigated a third signaling molecule -- called Sonic hedgehog -- that could overcome problems associated with FGF2 and VEGF therapy.

In a report appearing in the June 15 issue of Genes and Development, the team showed that activating hedgehog signals in adult mouse hearts led to an increase in the density of blood vessels in the heart.

Their findings suggest that a drug treatment that turned on or increased hedgehog signals could provide substantial benefit to patients suffering from ischemic heart disease and myocardial infarctions and offer an alternative to invasive procedures like surgery or angioplasty.

About 12 percent of heart patients are not eligible for bypass surgery, which redirects blood around clogged arteries, or for other procedures routinely used to open clogged vessels. That means each year in the United States, 100,000 to 200,000 patients could benefit from having another option for improving blood flow in the heart, according to the study's authors.

'Our study is the first to identify that hedgehog signaling pathways are operational in the developing and mature heart,' says senior author David Ornitz, M.D., Ph.D., the Alumni Endowed Professor of Molecular Biology and Pharmacology.

The hedgehog gene was discovered in fruit flies and named for the spiky appearance of fruit fly embryos with mutations of the gene.

'Hedgehog signaling is a good potential target for growing new vessels in the heart,' says first author Kory
'"/>




Page: 1 2

Related medicine news :

1. Anti-Cancer Drug Restores Normal Cell Growth
2. Low-dose Growth Hormone (GH) with diet and exercise may help weight loss
3. Human Growth Hormone Found To be Dangerous For Human Use
4. Stem Cells Found To Offer Promise For Hair Growth
5. Fish Found To Improve Fetal Growth
6. Growth Patterns In Childhood Could Predict Breast Cancer Later In Life
7. Stopping The Growth Of Viruses
8. Stopping The Growth Of Viruses
9. Turmeric Found To Slow Down Melanoma Growth
10. Protein acts as "Master Switch" that cuts off cells Cancer-Growth machinery
11. Record Growth Of Soya-Based Dairy Alternatives Over The Past Year In European Markets
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Growth Factor Aids Regeneration Heart Blood Vessel

(Date:4/21/2015)... April 21, 2015 Bulk food-grade ... 3.8 out of 5, indicating generally favorable purchasing conditions ... low barriers to entry and the fact that most ... relatively short distances,” says IBISWorld research analyst Hayden Shipp. ... country, typically serving local and regional markets.” Suppliers include ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 Lifeguard Master is ... offerings. All products are listed on the Lifeguard Master website ... of EMS workers who want a quality and flexible product ... “Our Spider Straps and color Spider Straps are some of ... use and made of sturdy, heavy nylon” , The Spider ...
(Date:4/21/2015)... CA (PRWEB) April 21, 2015 Dr. Zain ... just released an interesting infographic that takes a close look ... , The new infographic, which appears on both Dr. Kadri’s ... Rise of Plastic Surgery in the Age of the Selfie.” ... in Beverly Hills to a variety of A-list patients, ...
(Date:4/21/2015)... Invictus Medical has secured the ... for a second innovative technology aimed at making ... newborn infants’ cognitive development. , “This technology addresses ... have identified through extensive interviews and input from ... Invictus Medical’s Chief Technology Officer. “We believe this ...
(Date:4/20/2015)... (PRWEB) April 20, 2015 Construction ... facility in Stuarts Draft, an independent, nonprofit community ... and Waynesboro, Virginia. The project was an ongoing ... Stuarts Draft facility is expected to provide additional ... on Stuarts Draft Highway, the new facility features ...
Breaking Medicine News(10 mins):Health News:Bulk Food-Grade Transportation Services Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Bulk Food-Grade Transportation Services Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 2Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 3Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 4Health News:Beverly Hills Plastic Surgery Expert Dr. Zain Kadri Releases Thought-Provoking New Infographic 2Health News:Invictus Medical Secures Rights to Second Promising New NICU Technology 2Health News:Augusta Health Construction Wraps Up at Stuarts Draft 2
... types of blood pressures -- systolic pressure is created by ... the vessels and diastolic pressure is when the heart is ... is 120/80. The first number in a blood pressure reading ... is the diastolic pressure. ,A recent study shows ...
... According to a recent study conducted researchers suggest that ... from // having their tonsils and adenoids out. ... States. Most of the time, it is performed to ... however, doctors have also used the surgery to treat ...
... of hospitalization among people 65 or older but is ... heart damage or complications and the costs of care. ... test for high levels of the peptide in patients ... have congestive heart failure, in which the heart stops ...
... cancer in the United States. According to a recent study ... In addition, soy protein may help minimize the number and ... diets to female mice and followed their progress for one ... specific ingredients. Diet one contained milk protein, and diet two ...
... Previous studies show conflicting results over whether hormone replacement ... A recent study examines the pros and cons of ... combined HRT therapy for five years. All the women ... had menopausal symptoms, while others did not.Results show women ...
... with 32,800 middle-aged women has shown that there may be ... no risk factors whose blood has high amounts of iron.// ... in 1989-90 from women with no history of diabetes, cardiovascular ... had shown an average iron concentration of 109 nanograms/milliliter manifested ...
Cached Medicine News:Health News:Study On Self Measurement Of Blood Pressure 2Health News:‘Protein’ Produced By Overstressed Heart Muscle a Strong Indicator Of Heart Disea 2
(Date:4/20/2015)... This report analyzes the worldwide markets for Blood Pressure Monitoring ... Segments: Sphygmomanometers (Aneroid Sphygmomanometers, & Digital Sphygmomanometers), Ambulatory and Automated ... comprehensive analytics for the US, Canada , ... Asia-Pacific , Middle East ... and forecasts are provided for the period 2014 through 2020. ...
(Date:4/20/2015)... April 20, 2015  Johnson & Johnson (NYSE: ... business for the investment community beginning at 8:30 a.m. ... Hyatt Regency Hotel in New Brunswick, New ... Paul Stoffels , M.D., Worldwide Chairman ... , Worldwide Chairman, Pharmaceuticals will host the meeting. ...
(Date:4/20/2015)... 2015 The preclinical contract research organization Absorption ... and safety testing of medical devices, announces that its Chief ... workshop " Drug Transporters in ADME: From the Bench to ... The title of Dr. Hidalgo,s talk is "Modern Tools for ... "Transporter Tools of the Future." The workshop, organized ...
Breaking Medicine Technology:World Blood Pressure Monitoring and Measurement Instruments Industry 2World Blood Pressure Monitoring and Measurement Instruments Industry 3World Blood Pressure Monitoring and Measurement Instruments Industry 4World Blood Pressure Monitoring and Measurement Instruments Industry 5World Blood Pressure Monitoring and Measurement Instruments Industry 6World Blood Pressure Monitoring and Measurement Instruments Industry 7World Blood Pressure Monitoring and Measurement Instruments Industry 8World Blood Pressure Monitoring and Measurement Instruments Industry 9World Blood Pressure Monitoring and Measurement Instruments Industry 10World Blood Pressure Monitoring and Measurement Instruments Industry 11World Blood Pressure Monitoring and Measurement Instruments Industry 12World Blood Pressure Monitoring and Measurement Instruments Industry 13World Blood Pressure Monitoring and Measurement Instruments Industry 14World Blood Pressure Monitoring and Measurement Instruments Industry 15World Blood Pressure Monitoring and Measurement Instruments Industry 16World Blood Pressure Monitoring and Measurement Instruments Industry 17World Blood Pressure Monitoring and Measurement Instruments Industry 18World Blood Pressure Monitoring and Measurement Instruments Industry 19World Blood Pressure Monitoring and Measurement Instruments Industry 20World Blood Pressure Monitoring and Measurement Instruments Industry 21World Blood Pressure Monitoring and Measurement Instruments Industry 22World Blood Pressure Monitoring and Measurement Instruments Industry 23World Blood Pressure Monitoring and Measurement Instruments Industry 24World Blood Pressure Monitoring and Measurement Instruments Industry 25World Blood Pressure Monitoring and Measurement Instruments Industry 26World Blood Pressure Monitoring and Measurement Instruments Industry 27World Blood Pressure Monitoring and Measurement Instruments Industry 28Absorption Systems Chief Scientist Ismael Hidalgo to Present at International Workshop on Drug Transporters 2
... SARcode Corporation presented data today for their lead investigational ... trial, subjects receiving SAR 1118 demonstrated a reduction in ... as compared to placebo. These data were part of ... Vision and Ophthalmology (ARVO) Annual Meeting held in Fort ...
... 3, 2011 At the Board of Directors meeting held ... per share. The dividend is payable on June 15, 2011 ... About Sigma-Aldrich: Sigma-Aldrich is a leading ... to Improve the Quality of Life. Its chemical and biochemical ...
Cached Medicine Technology:SAR 1118 Demonstrates Encouraging Results in Phase 2 Study of Dry Eye Disease 2SAR 1118 Demonstrates Encouraging Results in Phase 2 Study of Dry Eye Disease 3
9 mm slightly curved blade. Hexagonal handle....
9 mm blade....
4 mm disposable bevel blade. Malleable shafts. Flat spot on handle designed to guide knife in perforation....
Storz Ear Knife Handle....
Medicine Products: