Navigation Links
Green Tea and COX-2 Inhibitors Combine to Slow Growth of Prostate Cancer

Drinking a nice warm cup of green tea has long been touted for its healthful benefits, both real and anecdotal. But now researchers have found// that a component of green tea, combined with low doses of a COX-2 inhibitor, could slow the spread of human prostate cancer.

In the March 1 issue of Clinical Cancer Research, researchers from University of Wisconsin-Madison demonstrate that low doses of the COX-2 inhibitor celecoxib, administered with a green tea polyphenol called pigallocatechin-3-gallate (EGCG), can slow the growth of human prostate cancer. Their experiments were performed in cell cultures and in a mouse model for the disease.

“Celecoxib and green tea have a synergistic effect -- each triggering cellular pathways that, combined, are more powerful than either agent alone,” said Hasan Mukhtar, Ph.D., professor of dermatology at the University of Wisconsin and member of Wisconsin’s Paul Carbone Comprehensive Cancer Center. “We hope that a clinical trial could lead to a preventative treatment as simple as tea time.”

Previous research has linked the cyclooxygenase-2 enzyme, commonly known as COX-2, to many cancer types, including prostate cancer, said Mukhtar. Mukhtar and his colleagues have previously shown COX-2 inhibitors like celecoxib (known under the brand name Celebrex?) suppress prostate cancer in animal models. COX-2 inhibitors also have been shown to cause adverse cardiovascular effects when administered at high doses over long durations.

In 2004, Mukhtar and his colleagues demonstrated that green tea polyphenol EGCG has cancer-fighting abilities of its own. Their study, published in Cancer Research, showed that EGCG can modulate the insulin-like growth factor-1 (IGF-1)-driven molecular pathway in a mouse model for human prostate cancer, pushing the cells toward programmed cell death (apoptosis).

“We believed that COX-2 inhibitors may still prove beneficial if used in combination with comp
'"/>




Page: 1 2 3

Related medicine news :

1. Green tea beneficial in preventing osteoarthritis
2. Eating Greens fights cancer
3. Green Onions Blamed in Outbreak
4. Green Tea Might Help Patients With Prostate Cancer
5. Yet Another Use For Green Tea Extract
6. Exposure To Greenery And Graffiti May Affect Obesity
7. Green Beans for Cancer Prevention and Treatment.
8. Can Green Tea Prevent Alzheimers?
9. Green Tea Consumption Found To Improve Clinical Outcome In Cancer Patients
10. Polyphenols in Green Tea Cause Liver Damage At High Doses
11. FDA Gives Green Signal To Sanofi-Aventis SAs Cancer Drug Taxotere
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Green Tea and COX Inhibitors Combine Slow Growth Prostate Cancer

(Date:8/22/2014)... (PRWEB) August 22, 2014 The regional ... Toyota Indiana is on the grow again. ... jobs by summer 2016 to boost production of the ... bring Toyota Indiana’s overall investment to $4 billion. This ... America while providing additional flexibility to adjust its product ...
(Date:8/22/2014)... 2014 As the controversy surrounding ... in uterine surgeries continues to grow, Bernstein Liebhard ... decided to limit coverage of uterine morcellation. According ... Cross-Blue Shield of Massachusetts will no longer cover ... as of September 1, 2014. Other insurers in ...
(Date:8/22/2014)... protein 11 (BIM) deletion in advanced non-small cell ... free survival (PFS) in epidermal growth factor receptor ... Asian patients. Also, BIM deletion independently predicts overall ... BIM protein can activate the programmed cell death ... BIM deletion has been detected in 12.8% of ...
(Date:8/22/2014)... Restore My Vision Today , a ... to help people discover how they can get rid ... instead improving their eyesight naturally has caught the attention ... “There’s a reason why the glasses and contacts industry ... people just assume that it’s their only option to ...
(Date:8/22/2014)... Hudson County, NJ (PRWEB) August 22, 2014 ... that a leading specialist in Internal Medicine, Geriatrics, ... joined the network, CarePoint Health Medical Group. Their ... of highly skilled and experienced physicians comprise CarePoint ... doctors and practices in Hudson County, representing a ...
Breaking Medicine News(10 mins):Health News:Toyota Indiana Adding 300 Jobs to Build More Highlanders 2Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 2Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 3Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 4Health News:Deletion predicts survival in advanced non-small cell lung cancer 2Health News:Restore My Vision Today: Review Exposes Natural Eye Restoration Guide by Dr. Sen and Dr. Samantha Pearson 2Health News:Dr. Reisner Joins CarePoint Health Medical Group 2
... LLC, is proud to announce the latest benefits and features on ... ... -- Healthy Directions, LLC, is proud to announce the latest benefits ... premium quality, doctor-formulated products that address a wide range of health ...
... levels of psychological distress than those who are more ... European Society for Medical Oncology,s Symposium on Cancer and ... a common problem in cancer. It is estimated that ... weight loss and malnutrition during the course of their ...
... is needed is a new classification system and an overall standardization ... neurotrauma expert Geoff Manley, MD, PhD, professor of neurological surgery, co-director ... neurotrauma at UCSF-affiliated San Francisco General Hospital. , ... ...
... and cancer plays a major role in this disparity. African ... present at a later, deadlier stage; and they have poorer ... what extent are each of these three factors responsible for ... in Journal of General Internal Medicine Feb. 18, ...
... 17, 2009, the first of two effective dates in ... goes into effect. This final rule adopts Accredited ... and National Council for Prescription Drug Programs (NCPDP) Versions ... Compliance with these standards is mandatory by January 1, ...
... key to treatment, scientists say , , FRIDAY, March 20 ... an important role in the severe lung damage suffered ... Their findings may open up new targets for treatment ... United States. , "Cystic fibrosis patients have a problem ...
Cached Medicine News:Health News:Healthylivingnetwork.com Announces Web Site Enhancements and Additional Product Offerings 2Health News:Healthylivingnetwork.com Announces Web Site Enhancements and Additional Product Offerings 3Health News:Focus on treating malnutrition in cancer patients, researchers say 2Health News:Traumatic Brain Injury: UCSF Neurosurgeon Calls For More Research, Improved Treatment Standard 2Health News:Traumatic Brain Injury: UCSF Neurosurgeon Calls For More Research, Improved Treatment Standard 3Health News:Study quantifies racial disparities in cancer mortality rates between blacks and whites 2Health News:Edifecs Announces New Version of Its Integrated HIPAA 5010 and ICD-10 Analysis and Migration Solution 2Health News:Edifecs Announces New Version of Its Integrated HIPAA 5010 and ICD-10 Analysis and Migration Solution 3Health News:Insights Give New Hope Against Cystic Fibrosis 2
(Date:8/21/2014)... 2014  eRelevance Corporation ( www.erelevancecorp.com ), a ... it has completed integration with Nextech, a popular ... and Dermatology practices. "Integration allows our ... practices using Nextech," stated Bob Fabbio , ... from the EMR we are able to automatically ...
(Date:8/21/2014)... 2014 /CNW/ - Eisai Limited is pleased to support the ... comic book available in Canada . The ... to educate children and their parents about epilepsy, the most ... more than 300,000 Canadians. Eisai is guided by a corporate ... which the patient is central – there was a need ...
(Date:8/21/2014)... 2014 /PRNewswire-iReach/ -- Inc. magazine today ... third straight year, No. 349 in Health on ... of the nation,s fastest-growing private companies. The list ... important segment of the economy—America,s independent entrepreneurs. Companies ... LinkedIn, Zillow, and many other well-known names gained ...
Breaking Medicine Technology:eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3
Thompson surgical radiotranslucent anterior lumbar retractor system....
... is the first true high-speed, high-torque touch control ... comparable to Legend Gold and runs at 73,000 ... design provides ergonomic positioning and true variable speed ... the Legend Gold Touch is also smaller, with ...
... The METRx Microdiscectomy System incorporates specially designed ... a surgical area in a minimally invasive ... diameter size from 5.3 mm to 20.8 ... inserted sequentially - one around the other ...
... System, a uniquely designed system combining ... two systems into one. Detachable blade ... site during retractor placement, providing better ... retractor body slides easily onto the ...
Medicine Products: