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Good News For Those Suffering From Excessive Sweating

e clinical effect of a previous injection diminished and patients reported a score of 3 or 4 on the

Hyperhidrosis Severity Scale (HDSS), indicating their underarm sweating was barely tolerable or intolerable and frequently or always interfered with their daily activities, and when a gravimetric measurement was recorded of at least 50 mg of spontaneous sweat in each axilla over five minutes at rest.

Interim results from this study showed that Botox continued to be effective with repeated treatment. After treatment sessions 2 and 3, 81 percent (83/104) and 78 percent (40/51) of patients, respectively, reported at least a 2-grade improvement in HDSS score. Repeated treatment with Botox also produced a consistent reduction (≥75 percent) in sweat production. Some of the conclusions from the study are the following:

· Patients reported significantly less occupational dissatisfaction and limitation. Before treatment, 66 to 72 percent of patients were somewhat or very dissatisfied with their ability to perform their current work activities, compared to just 9 to 20 percent of patients after treatment (p<0.001).

· Half the number of patients reported feeling “emotionally damaged or injured” because of their hyperhidrosis than those who had reported before. (76 to 83 percent of patients before vs. 32 to 42 percent after treatment, p<0.001).

· Patients reported significantly less limitation in interpersonal and social situations. Before treatment only 17 to 33percent of patients reported being somewhat or very satisfied with their ability to perform non-work activities, a proportion that increased to 78 to 88 percent of patients after treatment.

No serious treatment-related adverse events were reported. The most frequently reported adverse events were infection (respiratory system: 14 percent), infection (body as a whole: 12 percent) and injection-site pain (11 percent). The majority of adverse
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