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Global Heartbeat Control Suggests Therapy for Beating Heart Failure

trol most aspects of the integrated processes that fuel the heart by regulating the expression of genes involved at each step.

"The receptors control some 400 genes, and probably more," Gigure said. Rather than being randomly distributed, "the genes fell into precise categories of well-defined energy pathways." Further study of mice lacking ERR provided evidence that the receptor plays an important role in the cardiac energy-sensing machinery.

Among the genes targeted by the receptors, the researchers uncovered several that had been linked previously to cardiomyopathies, a finding that Gigure described as "the cherry on the sundae for us." Those direct links to human disease suggest that drugs targeting ERR receptors might hold promise for novel heart therapies. "There are not many ways to prevent heart failure, but molecules that act on these receptors might be one," he said.


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