Navigation Links
Genome Code Cracked for Breast and Colon Cancers

er than normal variations or minor changes with no effect on the gene product.

In total, the Hopkins team combed through 465 million nucleotides – several encyclopedias’ worth of letters – to find approximately 1,500 DNA nucleotides that differed from the normal code in important ways. Virtually all these mistakes were mere single-nucleotide 'typos.' Some 200 genes were significantly mutated; the mutated genes in breast and colon cancers were almost completely distinct, suggesting very different pathways for the development of each of these cancer types.

Says Kinzler, 'This gives us some understanding of why breast and colon cancers, and most likely other cancers as well, are very different diseases and develop through different processes. When we say this will drive cancer research for the next couple of decades, this is one of the reasons. Now researchers will study how these mutations occur in breast and colon cancers, perhaps searching for environmental agents or cellular processes that drive these changes.'

The Hopkins team also found that the average number of mutant genes in each cancer is about 100, and at least 20 are likely to be crucial for tumor formation. 'Each cancer has a different blueprint,' says Velculescu. 'No two patients are identical.'

Other cancers also can be evaluated using the Hopkins approach, which they say has been developed over the past two decades and made possible through recent advances in DNA sequencing and bioinformatics.

'These findings will guide and provide support for future comprehensive genetic studies including those envisioned by The Cancer Genome Atlas Project,' says Vogelstein. Future research will include performing similar analyses on other tumors types, charting the pathways through which each mutant gene acts, and looking for common mutations that can be targeted with cancer drugs or used to detect the disease earlier.



Source-Newswie
SR
'"/>




Page: 1 2 3 4

Related medicine news :

1. Human Genome Project Achieves Technological Triumph
2. Human Diseases May Have Clue In Human-Chimp Genome Difference
3. Race Based Genome Project Launched By Mexico
4. Dog (Mans best friend) Genome Sequenced
5. Decoding the Fungi Genome Will Save Millions of Lives.
6. Yeast Genome Unravels Genes Critical For Maintaining DNA Integrity
7. Unraveling the Secrets of MHC in Human Genome
8. NHGRI Aims To Sequence Primate Genomes
9. p53, the Guardian of Our Genome
10. Sea Urchin Genome Similar To Man And May Cure Diseases
11. Scientists Map Key Landmarks in Human Genome
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genome Code Cracked for Breast and Colon Cancers

(Date:10/1/2014)... 2014) Despite a policy focus on expanding ... this vulnerable population continues to have significant dental ... Journal of the American Dental Association , researchers ... University School of Dental Medicine report on the ... oral care provided by caregivers to adults with ...
(Date:10/1/2014)... Bedros Keuilian is not only the founder ... camps, he’s also considered the leading expert on marketing ... business summits, a line of high-demand fitness marketing systems ... Spike TV reality show to his name. , With ... for personal trainers and fitness business owners to focus ...
(Date:10/1/2014)... 01, 2014 Farmington Company today ... redefined mission and visual identity helping brokers, consultants ... with them to create greater benefit communication synergies. ... focuses on empowering customers to better leverage Farmington ... crown jewel of the rebrand is the refreshed ...
(Date:10/1/2014)... Jupiter, FL (PRWEB) October 01, 2014 ... Begley, Jr., scheduled to broadcast on Monday, October 20, ... In this episode, Innovations will go behind the scenes ... prevention programs. This segment will explore the practical help ... young adults, which teaches the warning signs of abuse, ...
(Date:10/1/2014)... 2014 On Sept. 9, Chapín Coffee ... the Martha Stewart American Made Awards (MSAMAs), an annual ... country in the fields of crafts, design, food and ... a finalist in the MSAMAs, which celebrates entrepreneurs and ... improving local communities and changing the way we shop, ...
Breaking Medicine News(10 mins):Health News:To improve oral health of adults with developmental disabilities, support caregivers 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 3Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 3Health News:Farmington Company Launches Rebrand and New Positioning 2Health News:Innovations to Explore Breakthroughs in Health and Wellness in Upcoming Episode Airing Monday, October 20, 2014 via Discovery Channel 2Health News:Chicago Coffee Start-up Makes a Big Impact, Earns National Recognition 2
... News) -- Elevated blood levels of a central nervous system ... by a lack of oxygen, according to a new study. ... can also help doctors assess the effectiveness of a body-cooling ... Johns Hopkins researchers said. GFAP is specific to central ...
... HealthDay Reporter , THURSDAY, Oct. 13 (HealthDay News) ... epilepsy remain free of seizures 10 years later, a new ... medication, and only when drugs can,t control seizures -- often ... for surgery. This study suggests that some patients with focal ...
... procedure that measures the amount of oxygen in the ... detect critical congenital heart disease (CCHD) in infants, and ... standard for CCHD diagnosis, according to a new research ... of Pediatrics (AAP) National Conference and Exhibition (NCE) in ...
... THURSDAY, Oct. 13 (HealthDay News) -- Smoky, inefficient indoor cooking ... developing nations contribute to 2 million deaths a year, according ... affects about 3 billion people, or nearly half the world,s ... in a commentary published in the current issue of the ...
... CHAMPAIGN, Ill. What if you could trace the history of ... camera, you could learn what factory made the ingredients in your ... or even how to recycle the phone. You could follow the ... along the way to ensure that the medicine you,re taking isn,t ...
... 13 (HealthDay News) -- Nearly one in four Americans with ... undiagnosed psoriatic arthritis, according to a new study. This ... United States who have been diagnosed with the disease, a ... and can lead to joint destruction and disability. For ...
Cached Medicine News:Health News:Protein May Help Spot Newborns With Brain Damage 2Health News:For Many, Epilepsy Surgery Effective Long-Term 2Health News:For Many, Epilepsy Surgery Effective Long-Term 3Health News:Globally, 2 Million Deaths a Year Linked to Smoky Stoves 2Health News:Packaging expert sees a social revolution in the evolving barcode 2Health News:Packaging expert sees a social revolution in the evolving barcode 3Health News:1 in 4 With Psoriasis May Have Undiagnosed Arthritis 2
(Date:10/1/2014)... 1, 2014  CVS Health is thanking its 26,000 ... in changing the way health care is delivered to ... Company,s retail pharmacies, mail service pharmacies and specialty pharmacies ... company name to CVS Health to reflect our broader ... innovations needed to shape the future of health," said ...
(Date:9/30/2014)... LONDON , Sept. 30, 2014 This report ... Million by the following Product Categories: Enteral Feeding Pumps, Nasogastric ... analytics for the US Canada, Japan , ... Latin America , and Rest of World. ... through 2018. Also, a six-year historic analysis is provided for ...
(Date:9/30/2014)... ROCKVILLE, Md. , Sept. 30, 2014 /PRNewswire/ ... natural way to modernize medicine, announced today the ... line of nutraceuticals developed to address men and ... staying healthy and vibrant into old age while ... line includes three condition-specific, whole-food and herb-based formulas, ...
Breaking Medicine Technology:CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 2CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 3Global Enteral Feeding Devices Industry 2Global Enteral Feeding Devices Industry 3Global Enteral Feeding Devices Industry 4Global Enteral Feeding Devices Industry 5Global Enteral Feeding Devices Industry 6Global Enteral Feeding Devices Industry 7Global Enteral Feeding Devices Industry 8Global Enteral Feeding Devices Industry 9Global Enteral Feeding Devices Industry 10Global Enteral Feeding Devices Industry 11Global Enteral Feeding Devices Industry 12Global Enteral Feeding Devices Industry 13Global Enteral Feeding Devices Industry 14Global Enteral Feeding Devices Industry 15Global Enteral Feeding Devices Industry 16Global Enteral Feeding Devices Industry 17Global Enteral Feeding Devices Industry 18Global Enteral Feeding Devices Industry 19
... SAN DIEGO , May 3 The Wireless-Life ... and policy makers to drive improved healthcare through advances in wireless technologies, ... WLSA,s mission. , , , ... http://www.newscom.com/cgi-bin/prnh/20100428/LA95139LOGO ) , , , ...
... 3 Simmons Browder Gianaris Angelides & ... the resolution of their client Synergetics USA, Inc.,s (Nasdaq: ... Alcon, Inc.  Synergetics announced on April 27, 2010 , ... and a Supply Agreement with Alcon, pursuant to which all ...
Cached Medicine Technology:Wireless-Life Sciences Alliance (WLSA) Applauds Partner Organizations for Supporting Goal of Improving Healthcare Via Wireless Technologies 2Wireless-Life Sciences Alliance (WLSA) Applauds Partner Organizations for Supporting Goal of Improving Healthcare Via Wireless Technologies 3Simmons Firm Announces Settlement of Contingent Fee Antitrust Lawsuit 2Simmons Firm Announces Settlement of Contingent Fee Antitrust Lawsuit 3
... a 28 amino-acid lipophilic peptide with a ... serine residue three, that is primarily expressed ... the mucosa of the fundus of the ... to those of leptin. Ghrelin stimulates food ...
... The Medtronic SelectSecure Lead System (Model 3830) ... Its unique, lumenless design allows for flexibility ... without sacrificing insulation thickness. The SelectSecure lead ... positioning of the lead in select locations ...
... Human sex hormone-binding globulin (SHBG) is ... steroids with relatively high specificity and low ... bound to SHBG) and, to a much ... C18 and C19 steroid structures and regulates ...
... is the glucuronide conjugate of 3alpha-androstanediol, ... [1,2]. 3alpha-diol G has strong androgenic ... bioactivity of testosterone [2]. Serum 3alpha-diol ... reduction of DHT, and in addition, ...
Medicine Products: