( Researchers from The Yale School of Med...)Genetics Plays A Crucial Role In Preemies' Destructive Eye Disease,Health

Researchers from The Yale School of Medicine have reported that genetics has a major role in influencing retinopathy of prematurity (ROP) in preemies//, a disease known to hamper the development of blood vessels in the retina and could cause blindness. This report is published in the November issue of Pediatrics.

“This is the first definitive study to show that genetic factors are a significant component of ROP, and to quantify the extent of that genetic contribution,” said lead author Vineet Bhandari, M.D., assistant professor of pediatrics at Yale School of Medicine.

ROP is most prevalent and severe in extremely low birth weight newborns with an overall incidence estimated to be as high as 68 percent among those born at less than 1,251 grams (2.75 pounds), and 93 percent in those born less than 750 grams (1.6 pounds). Despite early detection and intervention, ROP may lead to retinal detachment and blindness. In an attempt to treat ROP, researchers have sought significant factors, such as too much oxygen, that contribute to the disease. The Yale team hypothesized that there was a strong genetic connection involved in developing ROP.

They looked at contributing factors and outcomes for ROP within 200 twin pairs born at 32 weeks gestation or less. Study participants were from Yale, the Karolinska Institute in Sweden and the University of Connecticut. These 200 twin pairs had a mean gestational age and birth weight of 29 weeks and 1,332 grams (2.9 pounds), respectively.

“Our analyses showed that gestational age and duration of supplemental oxygen were the significant independent contributing factors for ROP,” said Bhandari. “Once significant non-genetic co-factors for ROP were identified, we calculated the genetic susceptibility and determined that 70 percent of the contribution to ROP was the result of genetic factors alone.”

“The magnitude to which genetic factors contribute to this major cause of infant morbi
'"/>




Page: 1 2
Related medicine news :

1. Genetics and cholesterol levels
2. Genetics helps in attacking cancer
3. Alcoholism Influenced By Both Genetics & Family Environment
4. Genetics linked to leukemia treatment success rate in children
5. Genetics Has A Major Role To Play In Body Shape.
6. Revolution in Genetics to Open Avenues for Treating Cancer
7. Faster way of producing Bird flu vaccine using Reverse Genetics
8. Genetics of Ageing with Preserved Mental Capacity.
9. Generation Scotland To Examine Relation Between Lifestyle, Genetics and Health
10. Genetics Might BE The Basis For Chronic Fatigue Syndrome
11. Personalized Genetics: Unraveling the Secret Code to Good Health.