Navigation Links
Genetics Of Mental Retardation

A new study published online on August 13 in Nature Genetics by researchers at the University of Washington and The Howard Hughes Medical Institute says that there// are many more causes of mental retardation. An example is the retardation caused by a large deletion in six genes on chromosome 17. The syndrome caused by this condition causes characteristic facial, behavioral, and other physical features that are identical to several other syndromes.

Working with colleagues in the UK and US, the researchers screened 290 children with mental retardation and identified several abnormal genetic events. The researchers were able to pinpoint the region of the specific deletion using NimbleGen's high-resolution CGH microarrays. "The ability of NimbleGen to rapidly generate custom-designed, high-density oligo arrays targeted to the specific chromosomal regions we were interested in provided us the key data in our study," stated Dr. Andrew Sharp, Senior Fellow and Rosetta Fellow of the University of Washington and first author on the paper. "Having these tools in hand gave us, in a single experiment, what would otherwise have taken months of work using conventional methods, and allowed unprecedented insight into the underlying biology and mechanism of genomic disease."

The deletion on chromosome 17 was seen in multiple children. Based on current data, this deletion potentially accounts for ~1% of cases of mental retardation, making it one of the most common genetic causes of mental retardation. The deletion, encompassing several genes, is associated with a region of DNA that is commonly reversed (or inverted) in one in five people of European descent. Intriguingly, this deletion seems to occur preferentially among children of individuals who carry the inversion.

The research was based on the hypothesis that the genome contains hotspots that are prone to instability and thus play a key role in the occurrence of genomic disorders. These hotsp ots are flanked on each side by large, repetitive regions of DNA, termed "segmental duplications". It is because of the repetitive nature of these regions that, during replication, the genome can become "confused" and duplicate, reverse, or delete itself within these regions.

Source: Eurekalert
'"/>




Related medicine news :

1. Genetics and cholesterol levels
2. Genetics helps in attacking cancer
3. Alcoholism Influenced By Both Genetics & Family Environment
4. Genetics linked to leukemia treatment success rate in children
5. Genetics Has A Major Role To Play In Body Shape.
6. Revolution in Genetics to Open Avenues for Treating Cancer
7. Faster way of producing Bird flu vaccine using Reverse Genetics
8. Genetics of Ageing with Preserved Mental Capacity.
9. Generation Scotland To Examine Relation Between Lifestyle, Genetics and Health
10. Genetics Might BE The Basis For Chronic Fatigue Syndrome
11. Personalized Genetics: Unraveling the Secret Code to Good Health.
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/19/2017)... ... January 19, 2017 , ... MB Business Capital, a division ... credit facility to Sunrise, Florida-based Management Health Systems, LLC, dba MedPro Healthcare Staffing ... recapitalization of MedPro led by Harren Equity Partners. Brightwood Capital Advisors provided ...
(Date:1/19/2017)... ... 2017 , ... Workrite Ergonomics announced this week the launch ... panel system was designed to deliver the ideal blend of acoustic and visual ... the visual privacy required to maintain concentration levels and increase productivity. The tranquility ...
(Date:1/19/2017)... Ashland, VA (PRWEB) , ... January 19, 2017 , ... ... planning services to the eastern Virginia region, is inaugurating a charity event to honor ... community. , While on duty last year, Chad Phillip Dermyer and his fellow officers ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... Reproductive Endocrinologists at Reproductive Medicine Associates of Connecticut (RMACT) have earned “Top ... Cynthia Murdock and Dr. Shaun Williams have each been chosen by their peers ...
(Date:1/19/2017)... ... January 19, 2017 , ... Sales Focus Inc. (SFI), a Maryland-based ... US market. , Over the past 20 years SFI has been recognized as the ... launched six new clients into the US market. The new clients include: Panacea ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- , , Marks E-QURE , ... distribution agreement, following similar agreements in Israel and ... 5 billion global market ... a leader in medical devices for the treatment of advanced wound care, announced ... (TeckMedica) in Colombia for the Company,s patented Bio-electrical Signal ...
(Date:1/19/2017)... Md. , Jan. 18, 2017   ... late-stage clinical company developing therapeutics designed to preserve ... of patients, today confirmed plans to initiate a ... Company,s modified-release reformulation of lovastatin lactone designed to ... smithii) in the gut to treat the ...
(Date:1/18/2017)... , Jan. 18, 2017  EnteroMedics Inc. ... medical devices using neuroblocking technology to treat obesity, ... the pricing of an underwritten public offering of ... to deducting underwriting discounts and commissions and offering ... is comprised of Class A Units, priced at ...
Breaking Medicine Technology: