Navigation Links
Genetic mystery behind muscle development unraveled.

New genes such as microRNAs (miRNAs) belong to the newly discovered group of genes. Researchers working at the University of North Carolina have discovered two genes // belonging to the microRNA group. These genes function was later attributed to the proper development of muscles in the organism.

The microRNAs were initially discovered (1993) in the genome of the worms. The genes have been fully studied and worked on by researchers to completely understand the functioning of these genes. It was then understood that they play a very important role as gene regulators in both multicellular organisms and humans.

"Our interest is in understanding, at the level of gene expression, how muscle cells develop. As microRNAs are gaining acceptance as global regulators of gene expression, we questioned whether they could be involved in the development of muscle," said Dr. Da-Zhi Wang, the senior and corresponding author of the study.

Muscle tissue is generated when myoblasts, or pre-muscle cells, stop proliferating and instead undergo irreversible changes (differentiation) that cause them to become myotubes, or mature muscle cells. The researchers studied two miRNAs – miR-1 and miR-133 – found exclusively in muscle cells. Because their genes are located so close to one another, miR-1 and miR-133 are always expressed together, yet they carry out opposing tasks.

The two miRNAs described in the UNC study are instrumental in determining if myoblasts proliferate or differentiate. The research showed that increasing the amount of miR-1 caused myoblasts to differentiate into mature muscle cells, but prevented their proliferation. To the contrary, increasing the amount of miR-133 caused the myoblasts to proliferate even more, but prevented them from undergoing differentiation.

Similar experiments carried out in developing frog embryos confirmed their finding. Increasing miR-1 caused more muscle tissue overall and fewer my oblasts, while increasing miR-133 led to more myoblasts but less muscle overall in the frog embryo.

"That was quite a surprise to many people because those two miRNAs are both equally expressed when muscles are differentiating, so we assumed that they are probably pushing muscle cells in the same direction. But after analyzing them, we found they have contradictory roles," Wang said.

(ANI)
'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... HILL, N.C. , June 24, 2016 /PRNewswire/ ... healthcare decisions and regulators/payers have placed more emphasis ... new environment, patient support programs in the pharmaceutical ... for patients, medications. Consequently, pharmaceutical companies are focusing ... ensure they are providing products and services that ...
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
Breaking Medicine Technology: