Navigation Links
Genetic mystery behind muscle development unraveled.

New genes such as microRNAs (miRNAs) belong to the newly discovered group of genes. Researchers working at the University of North Carolina have discovered two genes // belonging to the microRNA group. These genes function was later attributed to the proper development of muscles in the organism.

The microRNAs were initially discovered (1993) in the genome of the worms. The genes have been fully studied and worked on by researchers to completely understand the functioning of these genes. It was then understood that they play a very important role as gene regulators in both multicellular organisms and humans.

"Our interest is in understanding, at the level of gene expression, how muscle cells develop. As microRNAs are gaining acceptance as global regulators of gene expression, we questioned whether they could be involved in the development of muscle," said Dr. Da-Zhi Wang, the senior and corresponding author of the study.

Muscle tissue is generated when myoblasts, or pre-muscle cells, stop proliferating and instead undergo irreversible changes (differentiation) that cause them to become myotubes, or mature muscle cells. The researchers studied two miRNAs – miR-1 and miR-133 – found exclusively in muscle cells. Because their genes are located so close to one another, miR-1 and miR-133 are always expressed together, yet they carry out opposing tasks.

The two miRNAs described in the UNC study are instrumental in determining if myoblasts proliferate or differentiate. The research showed that increasing the amount of miR-1 caused myoblasts to differentiate into mature muscle cells, but prevented their proliferation. To the contrary, increasing the amount of miR-133 caused the myoblasts to proliferate even more, but prevented them from undergoing differentiation.

Similar experiments carried out in developing frog embryos confirmed their finding. Increasing miR-1 caused more muscle tissue overall and fewer my oblasts, while increasing miR-133 led to more myoblasts but less muscle overall in the frog embryo.

"That was quite a surprise to many people because those two miRNAs are both equally expressed when muscles are differentiating, so we assumed that they are probably pushing muscle cells in the same direction. But after analyzing them, we found they have contradictory roles," Wang said.

(ANI)
'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... ... February 12, 2016 , ... The law firm of Morrow, Morrow, ... The purpose of these scholarships is to encourage applicants to pursue a degree ... employment within these two parishes. , “We have available jobs in St. Landry ...
(Date:2/12/2016)... VA (PRWEB) , ... February 12, 2016 , ... CDRH Enforcement Trends: , Back to ... , As Winston Churchill said, “Those who don’t learn from history ... show what to expect when they come knocking this year. But that takes time. ...
(Date:2/12/2016)... Angeles, CA (PRWEB) , ... February 12, 2016 , ... ... With a hectic schedule, a demanding job, and no time to decompress, Rabinowitz found ... she dedicated herself to meditation for its impact on her life, implementing a 20-minute-per-day ...
(Date:2/12/2016)... Appleton, Wis. (PRWEB) , ... February 12, 2016 ... ... its second Lean Leadership Series at Zuckerberg San Francisco General Hospital on April ... to practice new behaviors and create new habits. The workshops cover a broad ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fisher House Foundation Chairman ... John J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns Director, ... VA Southern Nevada Healthcare System. This will be the first Fisher House in ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... N.J. , Feb. 12, 2016  Innophos Holdings, Inc. ... and nutritional specialty ingredients, today announced that it will host ... 10:00 am ET to discuss its fourth quarter and full ... --> The press release detailing fourth quarter and full ... after market close. --> ...
(Date:2/12/2016)... 2016 (Kanadische ... http://www.sedar.com ) und der Website ... --> http://www.sedar.com ) und ... abrufbar.    --> Telesta ... Konzernabschluss des zweiten Quartals und die ...
(Date:2/12/2016)... JOSE, Calif. , Feb. 12, 2016  SI-BONE, Inc., a ... System ® ("iFuse"), a minimally invasive surgical (MIS) device indicated ... that National Government Services, Inc. (NGS), the Medicare Administrative Contractor (MAC) ... Illinois , Maine , Massachusetts ... , New York , Rhode ...
Breaking Medicine Technology: