Navigation Links
Genetic failure in cloned animals

Researchers have found proof that cloned animals tend to harbor genetic defects that will disturb their development and lead to abnormalities, strengthening the rational that reproductive cloning of humans should be banned.// However, the researchers noted the technology still could be used safely for therapeutic cloning techniques, such as producing embryonic stem cells to treat diseases ranging from Parkinson's to diabetes.

Cloned animals have major dysregulation of multiple genes so they are not normal at all, principal investigator of the study Rudolf Jaenisch, a biologist at the Whitehead Institute for Biomedical Research.

Jaenisch's team looked at 5,000 genes in cloned mice and found hundreds of genes important to development were not correctly expressed in the animals, he said. Overall, about one out of every 20 genes was not expressed correctly in the placenta. Abnormal gene expression also was observed in the liver but at a lower rate.

This ultimately impacts the animal's development and causes all kinds of malformations, he said, and it probably explains why many clones die early, are obese or have other problems. Hans Scholer, director of University of Pennsylvania's Center for Animal Transgenesis and Germ Cell Research in Philadelphia, agreed the research "supports the notion that you shouldn't clone humans." Scholer himself reported research in May that found a single gene was vital to cloning success.

Because the animals appeared normal yet exhibited genetic defects, it should send a message to Severino Antinori, the controversial Italian physician who claims to have impregnated three women with cloned human embryos, Scholer told UPI. "It says, 'even if you show us the face of a beautiful baby, behind the face there might be a terrible problem,'" Scholer said.

Robert Lanza, vice president of medical and scientific development at Advanced Cell Technology of Worcester, Mass., which conducts reproductive cloning in animals, also concurred. The new study is "further scientific grounds to ban all human reproductive cloning," he told UPI. "This definitely raises a red flag for anybody who would want to use cloning for reproducing humans."

The cloning process -- which involves transferring DNA from a single cell of an animal into an egg cell and creating a relatively exact copy of that animal -- does not adequately reprogram the genes for proper development. In other words, the cloned animals showed genetic defects because the procedure does not replicate normal reproduction, Jaenisch said, although it is not yet understood how cloning interferes with the reprogramming process.

Jaenisch pointed out the research has no bearing on therapeutic cloning, which appears to pose no safety risks. Therapeutic cloning takes tissue derived from embryonic stem cells and places it in a fully-grown animal to treat disease. The inserted cells function normally and there does not appear to be any problem, he said. His group reported earlier this year they had used therapeutic cloning to cure a mouse of an immunodeficiency disease.

Scholer felt that it was working perfectly right. Embryonic stem cells derived from therapeutic cloning would be grown into specific types of cells such as heart or brain cells, he said. If a tissue sample turns out to be faulty or have defects, you just throw it away. But you can't do this with entire organisms" that have arisen from cloning.


'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: