Navigation Links
Genetic failure in cloned animals

Researchers have found proof that cloned animals tend to harbor genetic defects that will disturb their development and lead to abnormalities, strengthening the rational that reproductive cloning of humans should be banned.// However, the researchers noted the technology still could be used safely for therapeutic cloning techniques, such as producing embryonic stem cells to treat diseases ranging from Parkinson's to diabetes.

Cloned animals have major dysregulation of multiple genes so they are not normal at all, principal investigator of the study Rudolf Jaenisch, a biologist at the Whitehead Institute for Biomedical Research.

Jaenisch's team looked at 5,000 genes in cloned mice and found hundreds of genes important to development were not correctly expressed in the animals, he said. Overall, about one out of every 20 genes was not expressed correctly in the placenta. Abnormal gene expression also was observed in the liver but at a lower rate.

This ultimately impacts the animal's development and causes all kinds of malformations, he said, and it probably explains why many clones die early, are obese or have other problems. Hans Scholer, director of University of Pennsylvania's Center for Animal Transgenesis and Germ Cell Research in Philadelphia, agreed the research "supports the notion that you shouldn't clone humans." Scholer himself reported research in May that found a single gene was vital to cloning success.

Because the animals appeared normal yet exhibited genetic defects, it should send a message to Severino Antinori, the controversial Italian physician who claims to have impregnated three women with cloned human embryos, Scholer told UPI. "It says, 'even if you show us the face of a beautiful baby, behind the face there might be a terrible problem,'" Scholer said.

Robert Lanza, vice president of medical and scientific development at Advanced Cell Technology of Worcester, Mass., which conducts reproductive cloning in animals, also concurred. The new study is "further scientific grounds to ban all human reproductive cloning," he told UPI. "This definitely raises a red flag for anybody who would want to use cloning for reproducing humans."

The cloning process -- which involves transferring DNA from a single cell of an animal into an egg cell and creating a relatively exact copy of that animal -- does not adequately reprogram the genes for proper development. In other words, the cloned animals showed genetic defects because the procedure does not replicate normal reproduction, Jaenisch said, although it is not yet understood how cloning interferes with the reprogramming process.

Jaenisch pointed out the research has no bearing on therapeutic cloning, which appears to pose no safety risks. Therapeutic cloning takes tissue derived from embryonic stem cells and places it in a fully-grown animal to treat disease. The inserted cells function normally and there does not appear to be any problem, he said. His group reported earlier this year they had used therapeutic cloning to cure a mouse of an immunodeficiency disease.

Scholer felt that it was working perfectly right. Embryonic stem cells derived from therapeutic cloning would be grown into specific types of cells such as heart or brain cells, he said. If a tissue sample turns out to be faulty or have defects, you just throw it away. But you can't do this with entire organisms" that have arisen from cloning.


'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/25/2016)... ... May 25, 2016 , ... CloudLIMS, joins an elite ... Life Sciences Tech Solution Providers list of 2016 by CIOReview. , In a deliberate ... Life Sciences Tech Solution Providers 2016 has been concluded with. The positioning is based ...
(Date:5/25/2016)... ... May 25, 2016 , ... Cheryl Bowker of Bowker Insurance Group ... Dick McKenna Good Hands Legacy Award. McKenna ran one of Allstate’s most successful agencies ... inspire all those who knew him. The award named for him is not given ...
(Date:5/25/2016)... ... May 25, 2016 , ... Afrimesure specializes in providing clients ... to food and HVAC facilities. Their knowledgeable staff also takes care of the ... applications, Afrimesure offers a variety of MadgeTech systems available for sterilization and temperature ...
(Date:5/25/2016)... ... May 25, 2016 , ... Conrad ... annual Medical and Prescription Drug survey , an employee benefits ... which was conducted in December 2015, indicates that employers are turning to consumer ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... For more than fifty years, we've suffered ... we changed our diets to conform to the latest nutritional advice – advice that was ... the NIH, more than 2 in 3 American adults are considered to be overweight and ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 Cirujanos ... para ayudar a los médicos a compartir sus mejores ... a escala mundial. Profesionales médicos de Europa, África, ... han apuntado a la aplicación, que combina la transmisión ... entorno totalmente seguro. Educación   "Imagine ...
(Date:5/24/2016)... , May 24, 2016  Diana Russell suffers from ... organs from the inside out.  This disease has put ... on her children and grandchildren to leave her home.  ... Diana,s family cannot haul the wheelchair.  So if there ... car, and Diana is left to wait for the ...
(Date:5/24/2016)... May 24, 2016 Celsion Corporation (NASDAQ: ... company, today provided an update on its ongoing ... trial combining GEN-1, the Company,s DNA-based immunotherapy, with ... newly-diagnosed patients with advanced ovarian cancer who will ... GEN-1 is an IL-12 DNA plasmid vector formulated ...
Breaking Medicine Technology: