Navigation Links
Genetic failure in cloned animals

Researchers have found proof that cloned animals tend to harbor genetic defects that will disturb their development and lead to abnormalities, strengthening the rational that reproductive cloning of humans should be banned.// However, the researchers noted the technology still could be used safely for therapeutic cloning techniques, such as producing embryonic stem cells to treat diseases ranging from Parkinson's to diabetes.

Cloned animals have major dysregulation of multiple genes so they are not normal at all, principal investigator of the study Rudolf Jaenisch, a biologist at the Whitehead Institute for Biomedical Research.

Jaenisch's team looked at 5,000 genes in cloned mice and found hundreds of genes important to development were not correctly expressed in the animals, he said. Overall, about one out of every 20 genes was not expressed correctly in the placenta. Abnormal gene expression also was observed in the liver but at a lower rate.

This ultimately impacts the animal's development and causes all kinds of malformations, he said, and it probably explains why many clones die early, are obese or have other problems. Hans Scholer, director of University of Pennsylvania's Center for Animal Transgenesis and Germ Cell Research in Philadelphia, agreed the research "supports the notion that you shouldn't clone humans." Scholer himself reported research in May that found a single gene was vital to cloning success.

Because the animals appeared normal yet exhibited genetic defects, it should send a message to Severino Antinori, the controversial Italian physician who claims to have impregnated three women with cloned human embryos, Scholer told UPI. "It says, 'even if you show us the face of a beautiful baby, behind the face there might be a terrible problem,'" Scholer said.

Robert Lanza, vice president of medical and scientific development at Advanced Cell Technology of Worcester, Mass., which conducts reproductive cloning in animals, also concurred. The new study is "further scientific grounds to ban all human reproductive cloning," he told UPI. "This definitely raises a red flag for anybody who would want to use cloning for reproducing humans."

The cloning process -- which involves transferring DNA from a single cell of an animal into an egg cell and creating a relatively exact copy of that animal -- does not adequately reprogram the genes for proper development. In other words, the cloned animals showed genetic defects because the procedure does not replicate normal reproduction, Jaenisch said, although it is not yet understood how cloning interferes with the reprogramming process.

Jaenisch pointed out the research has no bearing on therapeutic cloning, which appears to pose no safety risks. Therapeutic cloning takes tissue derived from embryonic stem cells and places it in a fully-grown animal to treat disease. The inserted cells function normally and there does not appear to be any problem, he said. His group reported earlier this year they had used therapeutic cloning to cure a mouse of an immunodeficiency disease.

Scholer felt that it was working perfectly right. Embryonic stem cells derived from therapeutic cloning would be grown into specific types of cells such as heart or brain cells, he said. If a tissue sample turns out to be faulty or have defects, you just throw it away. But you can't do this with entire organisms" that have arisen from cloning.


'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/16/2017)... ... January 16, 2017 , ... Permobil has just completed ... of custom seating systems has a well-earned reputation for premium quality, with a ... innovation and growth in the custom seating business, which enjoys strong demand, and ...
(Date:1/16/2017)... CA (PRWEB) , ... January 16, 2017 , ... ... manuscript in the Aesthetic Surgery Journal , the official journal of The ... conducted on lower eyelid retraction surgery. The procedure is designed to correct drooping, ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... NexTec Group ... a group of 100 organizations honored for their accomplishments in the field of midmarket ... growth, industry leadership and recognition, and innovation. Selection is not based on revenue and ...
(Date:1/15/2017)... ... January 15, 2017 , ... "On Tour is a music themed ... and ease," said Christina Austin - CEO of Pixel Film Studios. , On ... edit the style and animation of their slideshows. Place each slide on top of ...
(Date:1/14/2017)... ... 2017 , ... Healthy living brand Moody Zook recently came ... With more and more people opting to go organic in their lifestyle, the ... to specific needs. , Moody Zook focused particularly on their newly launched activated ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... Stock-Callers is currently reviewing the following Medical Appliances ... WMGI ), Varian Medical Systems Inc. (NYSE: VAR ... NuVasive Inc. (NASDAQ: NUVA ). These companies belong ... finish on Thursday, January 12 th , 2017, with the ... health care companies in the S&P 500 were down less ...
(Date:1/13/2017)... , Jan. 13, 2017  Alfalfa, cattle, leafy greens and ... environmental sampling film , which emphasizes the food industry,s shift ... highlights how COPAN,s Swab Rinse Kit ... the surface sampling process in the wake of the new ... COPAN is expanding the U.S. production ...
(Date:1/13/2017)... 13, 2017 On Thursday, January ... Average, and the S&P 500 edged lower at the ... trading session in bearish territories. Taking into consideration yesterday,s ... this morning: Myriad Genetics Inc. (NASDAQ: MYGN ... Research Holdings Inc. (NASDAQ: INCR ), and ...
Breaking Medicine Technology: