( riation in IL-4 a gene that dampens do...)Genetic Variations Leads to Fever After Smallpox Vaccination,Health

riation in IL-4, a gene that dampens down the inflammatory response, also reduced fever risk.

Interestingly, studies in mice have shown that immune system molecules produced by the IL-1 and IL-18 genes are linked to tissue damage in viral myocarditis, raising the question of whether a more severe complication of smallpox vaccination might be associated with variations in these genes.

Stanley hopes further studies will delineate whether genetic alterations linked to fever also play a role in more serious vaccine complications. About 12 percent of children who receive the MMR vaccine develop fevers over 103 degrees, and about 4 percent of them go on to develop seizures in the weeks that follow vaccination.

There might be a real benefit if we could use this kind of screening to identify children who may be more susceptible to febrile seizures after MMR, Stanley says. If we can find ways to identify people at risk and medicate them to reduce the possibility of fever, we might be able to reduce the incidence of seizures.




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