( who get a fever after the smallpox vacc...)Genetic Variations Leads to Fever After Smallpox Vaccination,Health

who get a fever after the smallpox vaccine occasionally develop myopericarditis, a potentially life-threatening inflammation of the heart muscle or sac surrounding the heart. And a small percentage of children who get fevers after the MMR vaccine will develop seizures.

We dont know whether the same genetic variations we identified in our study are also linked to more serious vaccine complications, but our study raises that possibility, Stanley says. I think this study will point us in that direction in terms of looking for genetic alterations that predict more serious complications.

The Washington University scientists, working in collaboration with MRCE colleagues Robert Belshe, M.D., and Sharon Frey, M.D., at St. Louis University, studied the occurrence of fever in 346 individuals who had participated in previous smallpox vaccination clinical trials evaluating Dryvax, the vaccine given to U.S. military personnel. About 95 percent of study participants were white.

Using blood samples donated by study participants, the scientists analyzed SNPs, sites of common genetic variation, in 19 genes linked to immune response, viral replication or inflammation. They found eight alterations associated with fever in four of the genes.

Not surprisingly, those who received the vaccine for the first time were more likely to develop fever, but Stanley says, We were able to identify specific genetic alterations that contribute to fever even in people who had already received the vaccine before.

The research team found that variations in the IL-1 gene complex on chromosome 2 were most closely linked to an increased risk of fever. This complex of genes produces a molecule that stimulates fever and is involved in inflammation.

Additionally, several variations in the IL-18 gene on chromosome 11 increased fever risk, while one decreased the likelihood of fever. That gene is involved in revving up the immune system. One va
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