Navigation Links
Genetic Variations Associated With Risk of Venous Thrombosis Identified

Researchers have identified new genetic variations that may be associated with the risk of developing nonfatal // venous thrombosis in postmenopausal women, according to a study.

Deep vein thrombosis (blood clots in the thigh or leg) and pulmonary embolism (blood clots in the arteries leading to the lungs) cause significant illness and death in adult women, according to the background information in the article. The authors note that despite improved preventive treatments in high-risk patients, the incidence of venous thrombosis (VT) has not decreased.

In this study, Nicholas L. Smith, Ph.D., M.P.H., from the University of Washington, Seattle, and colleagues examined the association of common genetic variation in 24 clotting-related candidate genes with the risk of first-time VT in postmenopausal women. Study participants were 349 perimenopausal and postmenopausal women 30 to 89 years of age who sustained a first VT event between January 1995 and December 2002. The control group of 1,680 women included perimenopausal and postmenopausal women of the same age range who had no prior history of deep vein thrombosis or pulmonary embolism. Through blood samples taken from the study participants, the researchers analyzed genetic markers called haplotypes and changes in the DNA sequence called single nucelotide polymorphisms (SNP).

"Only the tissue factor pathway inhibitor gene demonstrated global association with risk. Five significant SNP associations were identified across three of the candidate genes (factors V, XI and protein C) in SNP analyses," the researchers report. Two of those associations had been previously reported. The researchers note that another 22 variants across 15 genes were also identified and classify them as "interesting associations."

"After accounting for multiple testing, five SNPs associated with VT risk were identified, three of which have not been previously reported. Replication of these nove l associations in other populations is necessary to corroborate these findings and identify which genetic factors may influence VT risk in postmenopausal women," the authors conclude.

Source-Eurekalert
'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... HILL, N.C. , June 24, 2016 /PRNewswire/ ... healthcare decisions and regulators/payers have placed more emphasis ... new environment, patient support programs in the pharmaceutical ... for patients, medications. Consequently, pharmaceutical companies are focusing ... ensure they are providing products and services that ...
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
Breaking Medicine Technology: