Navigation Links
Genetic Variations Associated With Risk of Venous Thrombosis Identified

Researchers have identified new genetic variations that may be associated with the risk of developing nonfatal // venous thrombosis in postmenopausal women, according to a study.

Deep vein thrombosis (blood clots in the thigh or leg) and pulmonary embolism (blood clots in the arteries leading to the lungs) cause significant illness and death in adult women, according to the background information in the article. The authors note that despite improved preventive treatments in high-risk patients, the incidence of venous thrombosis (VT) has not decreased.

In this study, Nicholas L. Smith, Ph.D., M.P.H., from the University of Washington, Seattle, and colleagues examined the association of common genetic variation in 24 clotting-related candidate genes with the risk of first-time VT in postmenopausal women. Study participants were 349 perimenopausal and postmenopausal women 30 to 89 years of age who sustained a first VT event between January 1995 and December 2002. The control group of 1,680 women included perimenopausal and postmenopausal women of the same age range who had no prior history of deep vein thrombosis or pulmonary embolism. Through blood samples taken from the study participants, the researchers analyzed genetic markers called haplotypes and changes in the DNA sequence called single nucelotide polymorphisms (SNP).

"Only the tissue factor pathway inhibitor gene demonstrated global association with risk. Five significant SNP associations were identified across three of the candidate genes (factors V, XI and protein C) in SNP analyses," the researchers report. Two of those associations had been previously reported. The researchers note that another 22 variants across 15 genes were also identified and classify them as "interesting associations."

"After accounting for multiple testing, five SNPs associated with VT risk were identified, three of which have not been previously reported. Replication of these nove l associations in other populations is necessary to corroborate these findings and identify which genetic factors may influence VT risk in postmenopausal women," the authors conclude.

Source-Eurekalert
'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2017)... ... , ... Groove Ring is excited to announce they've partnered with Olympic runner ... and all-purpose rings. Whether you’re an athlete, adventurer, professional, or love to venture the ... From the rock face to the auto shop, Groove Ring is the world's first ...
(Date:6/22/2017)... , ... June 22, 2017 , ... ... announced today that it has received certification for ANSI/ASIS PSC.1-2012. The company’s work ... in environments where the rule of law has been degraded. The PSC.1 standard ...
(Date:6/20/2017)... ... June 20, 2017 , ... Connance, ... health system, will present how predictive analytics drive reimbursement optimization, with a focus ... Orlando, June 25-28. , “The traditional approach to denied and underpaid claims ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... has published a new eBook titled “ 5 Questions to Ask Before Entering ... Analyst on the Genetic Test Evaluation (GTE) team, the book explores the various ...
(Date:6/20/2017)... ... , ... HOUSTON – Brazos Towers at Bayou Manor is proud to ... for today’s modern senior. Brazos Towers at Bayou Manor has more than 50 years ... them the services to support that lifestyle both now and in the future. Instead ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... CHICAGO , June 19, 2017  Hill-Rom Holdings, Inc. ... conference call and webcast on Friday, July 28, 2017, beginning ... Conference Call Audio Only Dial-in information: To participate in the ... Please dial into the call at least 10 minutes prior ... Code is 34090339.  ...
(Date:6/14/2017)... -- ivWatch LLC, a medical device company focused on improving ... pleased to announce it was the Bronze Winner last ... Equipment at the 2017 Medical Design Excellence Awards (MDEAs), ... award was presented by Medical Device and Diagnostics Industry ... New York during MD&M East, the ...
(Date:6/12/2017)... 12, 2017 Kineta, Inc., a biotechnology company focused ... Vice President of R&D and Head of Virology Kristin ... Preparedness for the Northwest and Beyond meeting sponsored by ... 14, 2017 from 8:30-10:30 AM PDT at the Agora Conference ... Dr. Bedard will be joined by other leaders in ...
Breaking Medicine Technology: