Navigation Links
Genetic Variation may Increase Premenstrual Depression Risk

A recent research has found that a particular genetic variation may be tied to an increased risk for severe premenstrual depression .

Known medically as premenstrual dysphoric disorder, or PMDD, this psychiatric condition affects approximately 8 percent of women in their childbearing years. It's characterized by bouts of major depression and/or anxiety and bad temper during the second half of the menstrual cycle. These symptoms settle with the onset of each menstrual period.

Now, scientists at the University of North Carolina at Chapel Hill and the National Institute of Mental Health have suggested that their study might able to find gene differences that may clarify why some women have these mood disorders and others don't.

"Our initial hope in the study was that by looking at steroid-related genes like those for receptors for steroid hormones such as estrogen, we would be able to find gene differences that might explain why some women have these mood disorders and others don't. This study may begin to provide important clues to the nature of that susceptibility, said Dr. David R. Rubinow, the study's senior author and the Meymandi distinguished professor and chair of psychiatry at UNC School of Medicine.

The study is the first to discover a genetic variation linked to a mood disorder associated with endocrine changes during the menstrual cycle, Rubinow said.

The research involved 91 women for whom the authors prospectively confirmed a diagnosis of PMDD over at least three months. Another 56 women who had no history of mood disorders related to the menstrual cycle served as a comparison group. All the women provided blood samples for genetic analysis.

The team discovered four specific genetic variants, called single nucleotide polymorphisms, in one of the two genes that encode the estrogen receptor. The variants, which are differences in strings of DNA nucleotides A, G, C, or T, w ere identified in the estrogen receptor alpha gene, ESR1.

The scientists found that compared to the control group, women with PMDD were considerably more likely to have the ESR1 gene variants.

"While these are preliminary findings that require replication in larger studies, we would argue that this may explain part of the variance among women in the susceptibility to developing this mood disorder. Studies have shown that PMDD is characterized by abnormal sensitivity to reproductive steroids like estrogen. As a receptor for the hormone that can trigger the onset of PMDD symptoms, ESR1 has clear physiologic relevance for this disorder," Rubinow said.

The authors acknowledge that as with other complex genetic disorders, the contribution to PMDD of polymorphisms in a single gene may not be large. In addition, they also noted that the findings may be telling us more about the control group.

They found that these women, who have no history of psychiatric problems or menstrual cycle-related symptoms, may have gene variants that protect against PMDD. According to Rubinow, "this is equally interesting because it may help us to understand resilience and protection, which are also very important."

Dr. Susan S. Girdler, professor of psychiatry and director of the UNC Psychiatry Stress and Health Research Program, pointed out that the severity of PMDD symptoms are as great or can be as great as those of women with full-blown major depression or major anxiety disorder.

"But what makes them different is that the symptoms are very time-limited and linked strongly with the women's menstrual cycle, she said.

Girdler emphasizes that to qualify for PMDD, symptoms must be severe enough to interfere with everyday functioning - to disrupt relationships, result in social withdrawal, even prompt thoughts of suicide.

"We are talking about women who meet very stringent diagnostic criteria for PMDD. This is not the garden variety PMS, she said.

The results of the study will appear in an upcoming print edition of the journal Biological Psychiatry.


'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... ... ... The Smart Machine Age is here, and it’s disrupting everything. Not only could ... in the United States may be taken over by technology in the next five ... steamrolls over colleagues is drawing to a close. Success will belong to those who ...
(Date:2/24/2017)... ... February 24, 2017 , ... With millions of Americans and ... that we all are aware of our options and are empowered with strength ... the launch of its newest edition of "Vision and Hearing" in USA Today, ...
(Date:2/24/2017)... ... , ... The narrative in “ Signal 8: An Australian Paramedic’s Story ” ... paramedic experiences. Schanssema describes the tragedies he saw, as well as his struggles with ... Schanssema, initially unsure of the career path he wanted to take, found fulfillment in ...
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... The ... national conference convening academic faculty engaged in or interested in palliative care education and ... will be held in North County San Diego on Sept. 28 and 29, ...
(Date:2/24/2017)... ... ... The International Association of Eating Disorders Professionals (iaedp) announces the 2017 top ... mannequin art competition. Selected from 15 submissions from around the nation, the top five ... annual iaedp Symposium, March 22 – 26 in Las Vegas. , This year, the ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 2017 Physician General Dr. Rachel Levine ... Jennifer Smith commended South Central EMS today ... using naloxone, a life-saving overdose reversal drug. The recognition ... specialist and overdose survivor who was saved due to ... "A significant part of fighting the opioid epidemic is ...
(Date:2/24/2017)... , Feb. 23, 2017 The U.S. ... the PhenoTest BC Kit, performed on the Pheno ... organisms that cause bloodstream infections and provide information ... respond to (antibiotic sensitivity). The test also reduces ... this important information, which can guide antibiotic treatment ...
(Date:2/24/2017)... , Feb. 23, 2017  Directors from Pharma To Market Pty ... have joined forces, resulting in the founding of Pharma To Market ... Pharma To Market are pleased to announce their expansion into ... Singapore . The company are delighted to appoint ... of the Singapore based entity. Joelle brings ...
Breaking Medicine Technology: