Navigation Links
Genetic Variation in Some Smokers Increases Chances of Developing COPD

A new study has found that some smokers have genetic predisposition to develop chronic obstructive pulmonary disease (COPD).

The research from Wake Forest University School of Medicine demonstrated that a genetic variation in some people increases their chances of developing COPD if they smoke tobacco.

"The genetic variant we studied seemed harmless on its own. But when someone has this variant, there is more of an adverse effect of smoking on lung function. Therefore, in combination with smoking, this genetic variant represents a risk factor for COPD," said Alireza Sadeghnejad, M.D., Ph.D., lead author.

The researchers studied two variations (-1112C and -1112T) of the interleukin-13 (IL-13) gene. The gene is responsible for the production of the IL-13 protein that is involved in pulmonary inflammation and susceptibility to COPD.

Everyone has two copies of the gene, one inherited from each parent. The investigation suggests that having two copies of -1112T in the IL-13 gene is associated with a more profound adverse effect of cigarette smoking on lung function.

Researchers examined 1,073 men at least 40 years old who had smoked 20 or more pack-years. One pack-year is equal to smoking one pack a day for a year. Participants underwent genetic testing and a pulmonary function test known as Forced Expiratory Volume, which is the volume of air that can be forced out in one second after taking a deep breath.

Jill Ohar, M.D., senior researcher and a professor of internal medicine-pulmonary, said it's likely that -1112C/T is one of several genetic variants that influence the risk of a smoker developing COPD. About 25 percent of smokers develop the disease, suggesting that genetic factors, in addition to environmental exposure (in this case cigarette smoking), play a role.

"This finding may help us to understand why some smokers develop COPD and improve our understanding of how the disease develops. It shows us that it's likely the gene/environment interaction sets you up for this disease," said Ohar.

Sadeghnejad said that by understanding more about the role of IL-13 in COPD, the protein may eventually be a target for new drugs for the disease.

The variant has been shown to be associated with asthma, which may help explain why COPD and asthma tend to cluster in families, Ohar said.

The study is published online and will appear in a future print issue of the American Journal of Respiratory and Critical Care Medicine.


Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:

(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... American Dental Association meeting in Washington D.C. revolved around the fact that proper dental ... health. The talk stressed the link between periodontal disease (more commonly referred to as ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... safe and convenient way to dispense prescription medications at home, so he invented ... way to monitor and dispense prescription medications. In doing so, it could help ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, revealed ... 1-1 ). More than 3.7 billion people under the age of 50 – or ... to WHO's first global estimates of HSV-1 infection . , "The data shocks us ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... innovative online platform for mental health and wellness consultation, has collaborated with a ... will bridge the knowledge gap experienced by parents and bring advice from parenting ...
(Date:11/27/2015)... ... 2015 , ... Indosoft Inc., developer and distributor of the ... LTS (Long Term Support) into its Q-Suite 5.10 product line. , Making the ... a version of Asterisk that will receive not only security fixes, but feature ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... 2015  The GE Health Cloud 1 was unveiled ... North America (RSNA) meeting in ... the new cloud ecosystem and its applications will connect radiologists ... and multidisciplinary teams – both inside and outside the hospital ... of GE. "As the digital industrial leader, we are betting ...
(Date:11/29/2015)... 29, 2015   National Decision Support Company (NDSC) ... base, including notable statewide implementations. As a result, ... ACR Select, more than 1 million times per ... ACR Select provides real-time feedback on the most ... has been implemented at over 100 healthcare systems ...
(Date:11/27/2015)... 27, 2015 --> ... go online. The potential to save costs, improve treatment ... far from fully exploited as yet. Here, particular emphasis ... either via mobile tablet or directly at the patients, ... ) -->      (Photo: ...
Breaking Medicine Technology: