Navigation Links
Genetic Variation Linked to Age-Related Macular Degeneration

The combination of a certain genetic variation, along with inflammatory factors and smoking, significantly increases the risk of the vision disorder age-related macular degeneration, according to a study.//

Age-related macular degeneration (AMD) is the most important cause of irreversible visual loss in the elderly of the Western world, according to background information in the article. Hereditary factors play a role in AMD, and inflammation also may be a factor.

Dominiek D. G. Despriet, M.D., of the Erasmus Medical Center, Rotterdam, the Netherlands, and colleagues assessed the association between the complement factor H (CFH) gene and AMD and investigated the effect of smoking, serum inflammatory markers, and genetic variation of C-reactive protein (CRP). The study included 5,681 individuals age 55 years or older who had the gene mutation CFH Y402H. Information on smoking, CRP serum levels, and other measures were assessed at baseline.

The frequency of CFH Y402H was 36.2 percent. At baseline, there were 2,062 persons (36.3 percent) with any type of AMD (prevalent cases). During an average follow-up of 8 years, 1,649 (35.5 percent) of 4,642 participants progressed to a higher stage of AMD (new cases), including 93 (5.6 percent) who developed late AMD.

The researchers found that that the CFH gene was a major risk factor for AMD. The gene was implicated in all stages of AMD from early hallmarks such as drusen (material that builds up in the retina of the eye) to vision-disabling late AMD and the risks increased with each successive stage to stage 11 for late AMD. Individuals homozygous (having two identical gene alleles at the corresponding site on a chromosome) for the CFH Y402H gene had a 48 percent cumulative risk of developing late AMD by age 95 years while this risk did not exceed 22 percent for noncarriers. Smoking and elevated serum CRP levels further increased the risk.

'These data suggest that CFH Y 402H may be a causal factor in more than 50 percent of all AMD cases in the general population,' the authors write.

'The effect of CFH is significantly influenced by environmental and genetic factors that determine the inflammatory response and activate the complement pathway.'

(Source: Newswise)
'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Patients who ... Cortland, OH, can now meet with Dr. Joseph Bedich for a consultation, with or ... simultaneously improving their oral health and functionality. , Dr. Bedich offers a ...
(Date:5/24/2017)... , ... May 24, 2017 , ... Myers Jackson is ... has the ability to sell luxury homes anywhere on the planet. The luxury home ... side from Hattiesburg to Houston city-scapes. A quick search of “11 Spyglass Hill Auction ...
(Date:5/24/2017)... Lake Orion, Michigan (PRWEB) , ... ... ... is a disease affecting the female reproductive tract in which the endometrial ... the pelvic structures causing inflammation and pain. Patients experiencing painful intercourse, painful ...
(Date:5/24/2017)... ... May 24, 2017 , ... Accordant Technology, a trusted ... ExtraHop delivers an analytics-first approach, layered with machine learning, that provides real-time visibility ... to the cloud to the edge. Through the new partnership, customers get the ...
(Date:5/24/2017)... Park, NY (PRWEB) , ... May 24, 2017 ... ... announced the practice is offering holistic pediatric dentistry options for its patients on ... context of the patient’s entire physical well being, and is one of the ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... May 15, 2017 Enterin Inc., a privately-held CNS ... developing novel compounds to treat Parkinson,s disease (PD), has enrolled ... a Phase 1/2a randomized, controlled, multicenter study involving patients with ... enroll 50 patients over a 9-to-12-month period. The first stage ... patients with PD. Participating sites include Denver ...
(Date:5/11/2017)... TORONTO , May 11, 2017  Thornhill ... ) has been awarded an $8,049,024 USD five-year, ... Defense through the Canadian Commercial Corporation (CCC) ( ... Field Anesthesia Systems to administer general anesthesia to ... environment.  "The US Marine Corps have ...
(Date:5/10/2017)... , May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of ... is based on extensive data analysis from GHI,s hospitals ... hospitals database for the region. The GHI database covers 86% ... offering more than 130 data points for each institution in ...
Breaking Medicine Technology: