Navigation Links
Genetic Variation In Bitter-Taste Receptor Gene Increases Alcoholic Risk

The risk for alcohol dependence is greatly increased if an individual has a variant form of a gene that controls the bitter-taste receptor on the tongue // . The taste receptor gene, called TAS2R16 is located on chromosome 7.

Researchers at the Washington University School of Medicine have studied more than 262 DNA samples, before arriving at the conclusion. Each of the family participated in a study called Collaborative Study of the Genetics of Alcoholism (COGA) and had at least three alcoholic individuals.

"In earlier work, we had identified chromosome 7 as a region where there was likely to be a gene influencing alcoholism risk. There's a cluster of bitter-taste receptor genes on that chromosome, and there have been several papers suggesting drinking behaviors might be influenced by variations within taste receptors. So we decided to look closely at these taste receptor genes," said principal investigator Alison M. Goate.

The widespread diversity in the taste receptor gene in the general population allowed the researchers to conduct an in-depth analysis of the genetic variation and further explore the association with risk of alcoholism. The extensive data revealed by the Human Genome project also helped the current research to a great extent.

From cell culture experiments, a single base variation in the taste receptor gene (less response to bitter taste) was found to increase the susceptibility to alcoholism. However, the more common variant form of the gene is very sensitive to bitter taste, conferring a low susceptibility to alcohol dependence. This variant was more likely to occur among African Americans (45%) and was very rarely seen among Caucasians (0.6%).

The authors further intend to extrapolate the results to human taste tests, to find out if the cell culture experiment results would hold good. If this were established, then it could probably pave way for decreasing an individual’s tendency to drink by manipulating the taste receptor gene.

"I don't think our result has any implications for the levels of alcoholism within different populations. We know that this polymorphism is more common in African Americans than in Caucasians, but the frequency of alcoholism still can be similar between the two groups because many genes and environmental factors influence risk", concluded Dr. Goate.


'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of indulgence ... high can result in disappointment, perhaps even self-loathing. However, those who set the bar ... from PsychTests.com reveals that behind the tendency to set low expectations is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Revolutionary technology includes multi-speaker listening to ... leaders in advanced audiology and hearing aid technology, has ... the world,s first internet connected hearing aid that opens ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... firsts,: , TwinLink™ - the first dual ...
(Date:6/23/2016)... June 23, 2016 The vast majority of ... dialysis facility.  Treatments are usually 3 times a week, ... visit, including travel time, equipment preparation and wait time. ... especially grueling for patients who are elderly and frail.  ... nursing and rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
Breaking Medicine Technology: