Navigation Links
Genetic Variation In Bitter-Taste Receptor Gene Increases Alcoholic Risk

The risk for alcohol dependence is greatly increased if an individual has a variant form of a gene that controls the bitter-taste receptor on the tongue // . The taste receptor gene, called TAS2R16 is located on chromosome 7.

Researchers at the Washington University School of Medicine have studied more than 262 DNA samples, before arriving at the conclusion. Each of the family participated in a study called Collaborative Study of the Genetics of Alcoholism (COGA) and had at least three alcoholic individuals.

"In earlier work, we had identified chromosome 7 as a region where there was likely to be a gene influencing alcoholism risk. There's a cluster of bitter-taste receptor genes on that chromosome, and there have been several papers suggesting drinking behaviors might be influenced by variations within taste receptors. So we decided to look closely at these taste receptor genes," said principal investigator Alison M. Goate.

The widespread diversity in the taste receptor gene in the general population allowed the researchers to conduct an in-depth analysis of the genetic variation and further explore the association with risk of alcoholism. The extensive data revealed by the Human Genome project also helped the current research to a great extent.

From cell culture experiments, a single base variation in the taste receptor gene (less response to bitter taste) was found to increase the susceptibility to alcoholism. However, the more common variant form of the gene is very sensitive to bitter taste, conferring a low susceptibility to alcohol dependence. This variant was more likely to occur among African Americans (45%) and was very rarely seen among Caucasians (0.6%).

The authors further intend to extrapolate the results to human taste tests, to find out if the cell culture experiment results would hold good. If this were established, then it could probably pave way for decreasing an individual’s tendency to drink by manipulating the taste receptor gene.

"I don't think our result has any implications for the levels of alcoholism within different populations. We know that this polymorphism is more common in African Americans than in Caucasians, but the frequency of alcoholism still can be similar between the two groups because many genes and environmental factors influence risk", concluded Dr. Goate.


'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
Breaking Medicine Technology: