Navigation Links
Genetic Variation In Bitter-Taste Receptor Gene Increases Alcoholic Risk

The risk for alcohol dependence is greatly increased if an individual has a variant form of a gene that controls the bitter-taste receptor on the tongue // . The taste receptor gene, called TAS2R16 is located on chromosome 7.

Researchers at the Washington University School of Medicine have studied more than 262 DNA samples, before arriving at the conclusion. Each of the family participated in a study called Collaborative Study of the Genetics of Alcoholism (COGA) and had at least three alcoholic individuals.

"In earlier work, we had identified chromosome 7 as a region where there was likely to be a gene influencing alcoholism risk. There's a cluster of bitter-taste receptor genes on that chromosome, and there have been several papers suggesting drinking behaviors might be influenced by variations within taste receptors. So we decided to look closely at these taste receptor genes," said principal investigator Alison M. Goate.

The widespread diversity in the taste receptor gene in the general population allowed the researchers to conduct an in-depth analysis of the genetic variation and further explore the association with risk of alcoholism. The extensive data revealed by the Human Genome project also helped the current research to a great extent.

From cell culture experiments, a single base variation in the taste receptor gene (less response to bitter taste) was found to increase the susceptibility to alcoholism. However, the more common variant form of the gene is very sensitive to bitter taste, conferring a low susceptibility to alcohol dependence. This variant was more likely to occur among African Americans (45%) and was very rarely seen among Caucasians (0.6%).

The authors further intend to extrapolate the results to human taste tests, to find out if the cell culture experiment results would hold good. If this were established, then it could probably pave way for decreasing an individual’s tendency to drink by manipulating the taste receptor gene.

"I don't think our result has any implications for the levels of alcoholism within different populations. We know that this polymorphism is more common in African Americans than in Caucasians, but the frequency of alcoholism still can be similar between the two groups because many genes and environmental factors influence risk", concluded Dr. Goate.


Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:

(Date:11/27/2015)... ... 2015 , ... An inventor, from Hopkinsville, Ky., thought there ... home, so he invented the patent-pending ELECTRONIC M.D. , The ELECTRONIC M.D. provides ... so, it could help to prevent potential overdose situations. As a result, it ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion is ... Pro X. With ProSidebar: Fasion, video editors can easily add an informative sidebar ... minimalist title opener. Utilize presets featuring self-animating drop zones, lines, bars, and text ...
(Date:11/27/2015)... ... ... A simply groundbreaking television series, "Voices in America", which is hosted by ... of issues that are presently affecting Americans. Dedicated to providing the world with a ... the subjects consumers focus on, one episode at a time. , In the ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... the largest, most successful and prominent nonprofit healthcare organizations in the country. They ... involvement with various organizations, and helped advance the healthcare industry as a whole ...
(Date:11/26/2015)... ... 2015 , ... Patients at Serenity Point Recovery, a holistic ... Thanksgiving Day to share the things that they are most grateful for today. ... channel, patients displayed what they wrote on index cards, describing the things that ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... November 26, 2015 ... nieuwe aanpak combineert immunotherapie met Bremachlorin-photodynamische therapie ... ) --> ... (Photo: ) ... Medisch Centrum (LUMC) blijkt ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "2016 Future ... Drugs of Abuse Testing Market: Supplier Shares, ... report to their offering. --> ... of the "2016 Future Horizons and ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Drug Monitoring (TDM) Market: Supplier Shares, ... Opportunities"  report to their offering.  ... the addition of the  "2016 Future ...
Breaking Medicine Technology: