Navigation Links
Genetic Variation In Bitter-Taste Receptor Gene Increases Alcoholic Risk

The risk for alcohol dependence is greatly increased if an individual has a variant form of a gene that controls the bitter-taste receptor on the tongue // . The taste receptor gene, called TAS2R16 is located on chromosome 7.

Researchers at the Washington University School of Medicine have studied more than 262 DNA samples, before arriving at the conclusion. Each of the family participated in a study called Collaborative Study of the Genetics of Alcoholism (COGA) and had at least three alcoholic individuals.

"In earlier work, we had identified chromosome 7 as a region where there was likely to be a gene influencing alcoholism risk. There's a cluster of bitter-taste receptor genes on that chromosome, and there have been several papers suggesting drinking behaviors might be influenced by variations within taste receptors. So we decided to look closely at these taste receptor genes," said principal investigator Alison M. Goate.

The widespread diversity in the taste receptor gene in the general population allowed the researchers to conduct an in-depth analysis of the genetic variation and further explore the association with risk of alcoholism. The extensive data revealed by the Human Genome project also helped the current research to a great extent.

From cell culture experiments, a single base variation in the taste receptor gene (less response to bitter taste) was found to increase the susceptibility to alcoholism. However, the more common variant form of the gene is very sensitive to bitter taste, conferring a low susceptibility to alcohol dependence. This variant was more likely to occur among African Americans (45%) and was very rarely seen among Caucasians (0.6%).

The authors further intend to extrapolate the results to human taste tests, to find out if the cell culture experiment results would hold good. If this were established, then it could probably pave way for decreasing an individual’s tendency to drink by manipulating the taste receptor gene.

"I don't think our result has any implications for the levels of alcoholism within different populations. We know that this polymorphism is more common in African Americans than in Caucasians, but the frequency of alcoholism still can be similar between the two groups because many genes and environmental factors influence risk", concluded Dr. Goate.


'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2017)... ... September 22, 2017 , ... “Letters From Home”: a moving compilation of ... value to God. “Letters From Home” is the creation of published author, John Allred, ... Cabinet of Jerry Savelle Ministries International, who has traveled and ministered on four continents. ...
(Date:9/22/2017)... ... September 22, 2017 , ... Egg ... life. Although frozen embryos have a slight statistical advantage for live births, frozen ... a wonderful opportunity for women undergoing medical treatment or who are concerned about ...
(Date:9/21/2017)... ... September 21, 2017 , ... With ProSlideshow Portrait from ... easy to do. Users can select from up to two layers of subject matter ... of a mouse all within Final Cut Pro X. , With ProSlideshow ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... — 1:30 p.m. – 3:00 p.m. ET, http://www.fdanews.com/processcapabilityindices      ... things wrong, run afoul of The Quality System Regulation (§820.250), and Devicemakers find ...
(Date:9/21/2017)... CA (PRWEB) , ... September 21, 2017 , ... ... lunch and learn with Infinity Behavioral Health Services for professionals in the addiction ... a Commercial Payer Audit . , Insurance companies and state and federal ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... -- Just 18 months after its February 2016 launch, market ... appointment of three new senior people to its rapidly ... and James Wright bring decades of ... Tammy Wynne joins as Director, Value ... has over ten years, experience in global market access ...
(Date:9/1/2017)... , Sept. 1, 2017 Michael ... Solutions, Inc , highlights opportunities for growth in his ... report that Marlin Equity is seeking a buyer for ... annual award-winning 22-year-old healthcare solutions Value Added Reseller and ... "As the healthcare market ...
(Date:9/1/2017)... , Sept. 1, 2017  Bayer will present the latest ... Society for Medical Oncology (ESMO) 2017 Congress, September 8-12 in ... include new preclinical and clinical data on Bayer,s marketed portfolio ... pipeline projects. "We ... minds in cancer research at ESMO," said Carsten Brunn ...
Breaking Medicine Technology: