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Genetic Tests in the Treatment of Depression Not Yet Useful

rom all symptoms of depression after 1 year of treatment is approximately 40 percent, and side effects cause 12 percent to 15 percent of people who start treatment to stop taking the drug. Following the recent FDA approval of a test to predict differences in the CYP450 gene, clinicians and patients must decide whether using such tests to choose a type or dose of an SSRI might improve the patient's response to treatment.

In early 2007, the EGAPP working group, an independent, non-federal panel that advises the CDC, will issue recommendations on the use of CYP450 tests in the treatment of depression based on the evidence report and other considerations, including alternative approaches for dosing and monitoring of drug therapy, patient access to testing, and cost. The working group will also assess current knowledge gaps and describe additional research needs identified by the report. Future evidence reports that are part of the AHRQ/CDC collaboration will evaluate the use of genomic tests for specific diseases or conditions, such as a rare type of inherited colorectal cancer.

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