Navigation Links
Genetic 'Roadmap' Charts Links Between Drugs and Human Disease

A research team led by scientists at the Broad Institute of MIT and Harvard announced today the development of a new kind of genetic “roadmap” that can connect human diseases// with potential drugs to treat them, as well as predict how new drugs work in human cells. Called the 'Connectivity Map,' the new tool and its uses are described in the September 29 issue of Science and in separate publications in the September 28 immediate early edition of Cancer Cell. The three papers show the map’s ability to accurately predict the molecular actions of novel therapeutic compounds and to suggest ways that existing drugs can be newly applied to treat diseases such as cancer. Based on the results, the papers propose a public project to expand this initial human Connectivity Map — in the spirit of the Human Genome Project — to accelerate the search for new drugs to treat disease.

'The Connectivity Map works much like a Google search to discover connections among drugs and diseases,' said senior author Todd Golub, the director of the Broad Institute’s Cancer program, an investigator at the Dana-Farber Cancer Institute, an associate professor of pediatrics at Harvard Medical School, and an investigator at the Howard Hughes Medical Institute. 'These connections are notoriously difficult to find in part because drugs and diseases are characterized in completely different scientific languages.'

A key challenge in biomedicine is to connect each human disease with drugs that effectively treat it and to understand the molecular basis for such drugs’ effects. To solve this problem systematically, the scientists described the effects of drugs and diseases in the common language of 'genomic signatures,' meaning the full complement of genes that the drugs turn on and off.

To create a first-generation Connectivity Map, the scientists measured the genomic signatures of more than 160 drugs and other biologically active compounds. They next developed a compu
'"/>




Page: 1 2 3

Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genetic Roadmap Charts Links Between Drugs and Human Disease

(Date:7/11/2014)... GA (PRWEB) July 11, 2014 Datalogic ... step in improving sanitation hospital wide. With their new ... the spread of disease, like the devastating MRSA, which ... The Gryphon GD4400-HC 2D and the Gryphon ... 2D barcodes and can even read barcodes off of ...
(Date:7/11/2014)... -- U.S. health officials have concluded that it,s highly ... during a safety mishap last month. But, the ... announced a moratorium on the transfer of any dangerous ... a report issued Friday, the CDC outlined several measures ... incident doesn,t occur again. Last month, as many as ...
(Date:7/11/2014)... enterprises today are shifting towards the changing trend in ... offer these global enterprises a strategic method to cut ... operational costs to companies. The aim to minimize operational ... market driver for expanding the managed services market in ... estimated to grow from $142.75 billion in 2013 to ...
(Date:7/11/2014)... 10, 2014) Obese and overweight firefighters are ... care providers, according to new research from The ... (UTHealth). , National guidelines state that health care ... of maintaining a healthy weight. Firefighters have high ... leading cause of line-of-duty deaths in firefighters. This ...
(Date:7/11/2014)... 11, 2014 (HealthDay News) -- Prostate cancer patients are ... less effective treatment and die sooner if they also ... data from more than 41,200 American men who were ... They followed them through 2009. Nearly 1,900 of the ... years before their prostate cancer was discovered. "Men ...
Breaking Medicine News(10 mins):Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 2Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 3Health News:CDC Issues Tough Report on Anthrax Scare 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:Depression May Make It Harder to Beat Prostate Cancer 2
... Germany and America who had treated injured protestors while ... to // leave Nepal by the King Gyanendra's government. ... detained Wednesday after he appeared on a private television ... brutally assaulted by the security forces. ,On ...
... at the McDonald’s or KFC restaurants, across the world, have ... levels of the same // food elsewhere. ,According to ... of Medicine, the researchers analysed various food items like McDonald's ... in many countries between 2004 and 2005, the Associated Press ...
... that been launched on a trial basis in Singapore would ... intensive care unit//. A camera hooked up beside the baby's ... to view the live footage on 3G-enabled mobile phones, Singapore ... on a three-month trial, during which the infants go online ...
... symposium titled ‘Challenging Intellectual Property’ will be analyzed and ... ,The Symposium will look into the aspects of ... production in economic development. It will also gauge the ... table, desirous of bringing a change in health research ...
... way to reverse the process of cell division. This ... could be an important milestone in the fight// against ... from the Oklahoma Medical Research Foundation have published their ... a million times in the human body each day. ...
... If you thought that McDonalds’ in USA serves the same ... and// think!,According to a study by three Danish doctors, fat ... as "trans fat" in foods purchased at McDonald's Corp and ... to the staggering research published in this week's New England ...
Cached Medicine News:
(Date:7/10/2014)... , 11. Juli 2014  Dilon ... für die molekulare Bildgebung, einschließlich molekularer ... die CE-Zulassung für sein Navigator ® ... Dilon das Produkt jetzt europaweit vertreiben. ... Großteil der europäischen Länder ausgedehnt und ...
(Date:7/10/2014)... Calif. , July 10, 2014 Integrated ... leader in advanced memory and analog IC solutions, today ... on Thursday, July 24, 2014, at 7:00 a.m. Pacific ... financial results for the fiscal 2014 third quarter ended ... call via telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific ...
(Date:7/10/2014)... , July 10, 2014  BC Technical, the ... MiE America , Inc., a leading provider of ... into a long-term agreement naming BC Technical as the ... MiE and BC Technical announced today ... to establish BC Technical as the service and systems ...
Breaking Medicine Technology:Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2
... seamless eliminating the possibility of leakage around glued ... temperature resistant gel trays meaning you do no ... added user friendliness, the Primo tanks come with ... The Primo Gel Systems are designed to be ...
... set up and safe to use, the Gel ... casting and running agarose gels. The unit is ... direct-connect power supply eliminates a tangled mess of ... space. Designed for safety and convenience, the power ...
... offers the HE 33 Mini Submarine Unit for nucleic ... 33 is designed for very fast separations of DNA ... acts as a heat-sink. Fill the base with coolant ... by either keeping the unit in a freezer or ...
... ready-to-use gels are the key components of ... by submerged gel electrophoresis. We provide other ... compatibility and optimal performance, at a reasonable ... a unique staining tray, the system includes ...
Medicine Products: