Navigation Links
Genetic Mutation in Mice Suggests Extinct Mammoth Had Light and Dark Fur

Biologists at the University of California, San Diego have found that the main color differences among Florida’s mice—which are darker on the mainland//, but lighter on the barrier islands to blend in with the white sand dunes—are largely due to a simple genetic mutation.

Their discovery, detailed in the July 7 issue of the journal Science, is one of the first to demonstrate how a small change in a single nucleotide—the smallest subunit of a gene—can affect the survival and evolutionary fitness of an organism in the wild.

Because the mice differ not only in overall color, but in pigmentation pattern, the study also provides geneticists with a first step toward understanding how color patterns, such as zebra stripes and leopard spots, are generated in animals. And it raises the possibility that other vertebrates, such as mammoths, also evolved similar color variations using the same genetic mutation.

In a companion paper published in the same issue of Science, researchers in Germany report the discovery of this same mutation within DNA extracted from a 43,000-year-old bone of a wooly mammoth preserved in the permafrost of Siberia. Because the variations occur in the same nucleotide used by the Florida beach mice to alter their coat color, the University of Leipzig scientists say, populations of mammoths during the last Ice Age were likely composed of dark- and light-coated individuals.

“While there is growing evidence that phenotypic differences between organisms, like humans and chimps, are largely controlled by changes in gene regulation, these two studies are striking examples of how amino acid changes in structural proteins can also be important,” says Hopi Hoekstra, an assistant professor of biology at UC San Diego who headed the team that discovered the genetic roots of the color differences in Florida’s mice.

The coat pattern and color differences among populations of mice on the mainland and the barri er islands off the Florida Gulf and Atlantic coasts have been studied extensively since the 1920s, first by Francis Sumner of UCSD’s Scripps Institution of Oceanography. Sumner used the mice as a textbook example of how small, geographically isolated populations could adapt to their new environments and diverge into distinct subspecies.

Known to scientists as Peromyscus polionotus, mice living on the mainland have dark coats, which help them blend in with the vegetation and avoid their main predators—owls, hawks and herons—that hunt prey by sight. But on five barrier islands off the Florida Gulf coast and three off Northern Florida’s Atlantic coast, geographic isolation of the populations has resulted in eight distinct subspecies of beach mice, each with distinctive coat patterns that are lighter in color than their mainland counterpart.

“We know from geological evidence that the barrier islands are very recent, less than 6,000 years old,” says Hoekstra. “So these color mutations may have evolved rapidly.”

While scientists have been studying the genetics of complex coat patterns of these mice for nearly a century, few suspected that the simple mutation of a single nucleotide could have such a major impact on their coloration.

“We were surprised that this one gene could explain up to 36 percent of the variation we see in the mice,” she says. “It’s a large effect mutation. And what it says is that adaptation does not always occur gradually, but may happen in these relatively large jumps.”

Hoekstra and her colleagues—Rachel Hirschmann of UCSD’s Division of Biological Sciences and Richard Bundey and Paul Insel of UCSD’s Department of Pharmacology—discovered the single nucleotide mutation in the melanocortin-1 receptor, a gene which regulates the pigmentation of hair color.

In laboratory mating of the different subspecies to produce genetic crosses, the UCSD scientists report in their paper that the variations of this gene account as much as 36 percent of the color variation in Gulf Coast mice. Surprisingly, however, this mutation was absent in the two Atlantic Coast subspecies, even though these Atlantic coast beach mice have similarly light colored coats. The results suggest that beach mice gain their light coloration through different genetic mechanisms.

“There is apparently more than one way genetically to become a light-colored beach mouse,” says Hoekstra.

Other genes also contribute to the differences in the coat patterns among the mice. But, concedes Hoekstra, “We know very little genetically about how coat patterns are generated in mammals. This study is a first step toward understanding this complex genetic process.”

Unfortunately for the scientists, the subjects of their study are disappearing rapidly. One of the eight original subspecies studied by Sumner has since become extinct and six of the seven remaining subspecies are considered endangered because their habitats are being destroyed by human development.

“These mice exist on beautiful white-sand beaches, inhabit the sand dunes and feed on sea oats,” says Hoekstra. Their pristine habitat is being destroyed by human development coupled with hurricanes.

“Unfortunately these mice like the same habitat where people want to build beach homes and the two don’t coexist well together,” she adds. “The mice are now only found in protected areas, and hurricanes become a big threat because these beach mouse populations, which are so wonderfully adapted to their environment, are now small and fragmented”

(Source: Newswise)
'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... January 20, 2017 , ... A new partnership between ... they no longer use or need, from clothes to couches to dressers and bicycles. ... and take them to the nearest Goodwill donation center through February 28th. , ...
(Date:1/20/2017)... Miami, Florida (PRWEB) , ... January 20, 2017 , ... ... in head lice cases in families with school-aged children since the holiday season. ... spend the holidays with their families, sharing hugs and taking photos, which is the ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... its sugar-free alternative VW+ 002. The drinks have been produced in collaboration with ... to perform during your workout. , After a successful launch in Sweden last ...
(Date:1/20/2017)... ... 2017 , ... D R Burton Healthcare Products LLC, makers ... in a study indicating superior performance against competitive products in secretion clearance. ... Positive Expiratory Pressure Devices During Simulated Breathing“ was published in the winter issue ...
(Date:1/20/2017)... ... January 20, 2017 , ... “God's Miracle Man: Against All Odds”: an ... of published author, Keith C. A. Tucker, son of Minister Delores Pinnock and a ... by Reverend Mark Hardy , “While sitting up in bed, I felt a pounding ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017 Shire plc (LSE: ... U.S. Food and Drug Administration (FDA) has acknowledged receipt ... Application (NDA) for SHP465, a long-acting, triple-bead, mixed amphetamine ... once-daily treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). The FDA is ... 20, 2017, the designated Prescription Drug User Fee Act ...
(Date:1/19/2017)... 19, 2017 Pfizer joins ... Milner Therapeutics Consortium   Major research ... Cambridge   The Milner Therapeutics ... ) as a partner to the Milner Therapeutics Consortium. ... the efficient transfer of materials between industry and academia ...
(Date:1/19/2017)... Florida , January 19, 2017 ... Trump administration appears serious about reducing the FDA,s ... and innovation in the medical drug industry, many ... ahead with new clinical trials and development of ... companies forging ahead with recent developments include:  Moleculin ...
Breaking Medicine Technology: