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Genetic Mutation That Makes Common Cancers Resistant to Drugs Identified

e study's lead author.

"The next step is to determine the prevalence of the AKT1 mutation in different populations and, hopefully, use the information gained to stratify patients going into clinical trials for AKT inhibitors," he added.

The researchers say that their findings may help in the advancement of cancer treatment and drug development, if they are validated by further studies.

"This is a gorgeous study that used a variety of sophisticated techniques to provide new insights into the tumourigenic process," said Dr. Bert Vogelstein, Director of the Ludwig Center for Cancer Genetics and Therapeutics at The Johns Hopkins Kimmel Cancer Center.


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