Navigation Links
Genetic Map Reveals How Drugs Fight Diseases: Study

US scientists reported an initial success in building an extensive catalog of information about how drugs affect various healthy and diseased cells. //

This so-called "Connectivity Map" will be able to reveal links among drugs, genes and diseases, the researchers wrote in the latest issue of Science.

The findings, reported Thursday by US scientists and also published in the journal Cancer Cell, may accelerate the search for new drugs to treat diseases, by predicting the molecular actions of novel therapeutic compounds and revealing how existing drugs can be newly applied to treat diseases such as cancer.

A key challenge in biomedicine is to connect each human disease with drugs that effectively treat it, and to understand the molecular basis for such drugs' effects.

To solve this problem systematically, the researchers described the effects of drugs and diseases in the common language of "genomic signatures", meaning the full complement of genes that the drugs turn on and off.

The researchers collected gene-expression profiles from cultured human cells treated with 164 bioactive small molecules, including the anti-cancer drug gedunin, estrogen and certain antipsychotics.

They also collected genetic signatures from cells affected by conditions such as diet-induced obesity, Alzheimer's disease, and a drug-resistant form of leukemia.

Using pattern-matching software to mine these data, the researchers identified potential mechanisms of drug action, confirmed previous applications of known drugs, and discovered potential new uses for known drugs.

"This is a powerful discovery tool for the scientific community," said Justin Lamb, the lead author of the Science paper and a senior scientist at the Broad Institute's Cancer programme.

"By analysing just a small fraction of available drugs, we have already confirmed several biological connections between drugs and human
'"/>




Page: 1 2

Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genetic Map Reveals How Drugs Fight Diseases Study

(Date:7/30/2015)... WASHINGTON (PRWEB) , ... July 30, 2015 , ... ... the scientific program at ATA’s 21st Annual Meeting and Tradeshow focused exclusively on ... more than 300 cutting-edge health care technology vendors, will take place May 14-17, ...
(Date:7/30/2015)... County, CA (PRWEB) , ... July 30, 2015 , ... ... County, Los Angeles, Riverside, and San Bernardino, recently announced that the Centers for Medicare ... new rating system of home health care providers. 24/7 Care At Home’s agency is ...
(Date:7/30/2015)... ... ... Ross A. Clevens, MD, FACS has been reappointed by the University ... This is Dr. Clevens’ second appointment by the prestigious school. Over the past ... and a valuable mentoring program for medical students. , The University ...
(Date:7/30/2015)... Los Angeles, California (PRWEB) , ... July 30, 2015 , ... ... of the success of the 2015 Special Olympics World Games, the largest sports and ... Angeles since the 1984 Olympic Games. , The World Games, held July 25 through ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... Ocean Hills ... available, including the very rare “no recommendations.” No recommendations means CARF found no areas ... is a notation that less than 3% of all facilities receive. In addition, Ocean ...
Breaking Medicine News(10 mins):Health News:Presentation Proposals for ATA 2016 are Now Being Accepted Online at ATA2016.com 2Health News:Presentation Proposals for ATA 2016 are Now Being Accepted Online at ATA2016.com 3Health News:24/7 Care At Home Earns a 5-Star Rating from the Centers for Medicare and Medicaid (CMS) 2Health News:Leading Melbourne Facial Plastic Surgeon Reappointed by UCF 2Health News:Leading Melbourne Facial Plastic Surgeon Reappointed by UCF 3Health News:WesternU Makes Big Impact at Special Olympics 2Health News:WesternU Makes Big Impact at Special Olympics 3Health News:Ocean Hills Recovery Receives Accreditation from CARF International 2
... City of Hope leads study showing efficacy of ... ... National,Marrow Donor Program (NMDP) has selected an abstract written by Dr.,Auayporn Nademanee, ... City of Hope, and Dr. Robert Chow,Founder and Global Medical Director for ...
... World Diabetes Day, November 14,is observed every year ... by others with an interest in diabetes. This year,s ... excellent opportunity,to focus on the significant increase in type ... Funded by the National Institutes of Health (NIH), researchers ...
... Percent of People with ... (Spinal Arthritis), ABBOTT PARK, Ill., Nov. 8 A ... decrease in the rate of uveitis flares by approximately half ... of the spine, and may also be associated with other ...
... Corporation,(Nasdaq: RGEN ) today reported results for the ... Total revenue for the quarter was,$5,352,000 compared to $2,865,000 ... 30, 2006, an increase of $2,487,000 or 87%. Total,revenue ... revenue.,Gross profit on product revenue for the second quarter ...
... IDMI ) today announced its financial results for ... information presented,represents the consolidated results of IDM Pharma and ... $33.2 million as of September 30,2007 compared to $37.3 ... 31, 2006. The Company,s net cash outflow from operations ...
... health diagnosis at the point-of-care and begin triage faster and easier ... ... UNION CITY, Calif., Nov. 8 Abaxis, Inc.,(Nasdaq: ABAX ), ... the U.S. Food and Drug,Administration (FDA) has granted waived status under ...
Cached Medicine News:Health News:Study on Plasma-Depleted Cord Blood Transplantation Receives Best Abstract Award From The National Marrow Donor Program 2Health News:Study on Plasma-Depleted Cord Blood Transplantation Receives Best Abstract Award From The National Marrow Donor Program 3Health News:Study on Plasma-Depleted Cord Blood Transplantation Receives Best Abstract Award From The National Marrow Donor Program 4Health News:World Diabetes Day Spotlights Type 1 Diabetes Increase and World Class Response 2Health News:World Diabetes Day Spotlights Type 1 Diabetes Increase and World Class Response 3Health News:Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab) 2Health News:Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab) 3Health News:Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab) 4Health News:Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab) 5Health News:Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab) 6Health News:Repligen Reports Second Quarter Fiscal Year 2008 Financial Results 2Health News:Repligen Reports Second Quarter Fiscal Year 2008 Financial Results 3Health News:Repligen Reports Second Quarter Fiscal Year 2008 Financial Results 4Health News:Repligen Reports Second Quarter Fiscal Year 2008 Financial Results 5Health News:Repligen Reports Second Quarter Fiscal Year 2008 Financial Results 6Health News:Repligen Reports Second Quarter Fiscal Year 2008 Financial Results 7Health News:IDM Pharma Reports Third Quarter 2007 Financial Results 2Health News:IDM Pharma Reports Third Quarter 2007 Financial Results 3Health News:IDM Pharma Reports Third Quarter 2007 Financial Results 4Health News:IDM Pharma Reports Third Quarter 2007 Financial Results 5Health News:IDM Pharma Reports Third Quarter 2007 Financial Results 6Health News:IDM Pharma Reports Third Quarter 2007 Financial Results 7Health News:IDM Pharma Reports Third Quarter 2007 Financial Results 8Health News:IDM Pharma Reports Third Quarter 2007 Financial Results 9Health News:IDM Pharma Reports Third Quarter 2007 Financial Results 10Health News:Abaxis Announces First Ever CLIA-Waived Comprehensive Metabolic Panel 2Health News:Abaxis Announces First Ever CLIA-Waived Comprehensive Metabolic Panel 3Health News:Abaxis Announces First Ever CLIA-Waived Comprehensive Metabolic Panel 4
(Date:7/30/2015)... , July 30, 2015 Vermillion, ... on gynecologic disease, announced today it will ... after the market close on Thursday, August ... call and webcast at 4:30pm Eastern.Conference Call ... at 4:30pm Eastern/1:30pm Pacific  Domestic: ...
(Date:7/30/2015)... VIEJO, Calif. , July 30, 2015 /PRNewswire/ ... aspiring to eliminate all preventable hospitalization, recently received ... that its Remote Patient Intelligence (RPI) solution meets ... the FDA intends to exercise "Enforcement Discretion." ... "are not subject to further FDA regulatory requirements ...
(Date:7/30/2015)... What can be expected from the ... grow at the fastest rates? Visiongain ,s brand ... data, trends, opportunities and prospects there. Our ... graphs. Discover the most lucrative areas in the industry ... you assess forecasted sales at overall world market and ...
Breaking Medicine Technology:FDA Clears Way for Commercial Marketing of Sentrian Remote Patient Intelligence Solution 2FDA Clears Way for Commercial Marketing of Sentrian Remote Patient Intelligence Solution 3Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 2Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 3Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 4Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 5Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 6
... Nov. 11 Pharma market research thought leaders are discovering ... opportunities in the pharmaceutical industry. The last twelve months ... Pharmaceutical market research is no exception. But those ... information today will certainly rise to be the new leaders ...
... VVUS ) today announced that Timothy Morris, chief financial officer, ... Markets 6th Annual Healthcare Conference. , The VIVUS presentation will take ... November 18, 2009 at 1:45 p.m. ET. A live webcast ... http://ir.vivus.com . , About VIVUS ...
Cached Medicine Technology:Executives Reveal Secrets to Capitalize on New Developments in Pharmaceutical Marketing Research 2VIVUS to Present at Lazard Capital Markets Healthcare Conference 2
... new Oculus Easygraph is a corneal ... tools you need for refractive surgery, ... therapy contact lens fitting in a ... 4" package. All you need to ...
The only ergonomic work station of its kind with an optional built-in keratograph and flat-screen. The Concepta is a modern workstation for the examination and refraction of patients....
The natural look of 3 in 1 technology in virtually any prescription....
Dot matrix pattern for light eyed patients....
Medicine Products: