Navigation Links
Genetic Map Reveals How Drugs Fight Diseases: Study

US scientists reported an initial success in building an extensive catalog of information about how drugs affect various healthy and diseased cells. //

This so-called "Connectivity Map" will be able to reveal links among drugs, genes and diseases, the researchers wrote in the latest issue of Science.

The findings, reported Thursday by US scientists and also published in the journal Cancer Cell, may accelerate the search for new drugs to treat diseases, by predicting the molecular actions of novel therapeutic compounds and revealing how existing drugs can be newly applied to treat diseases such as cancer.

A key challenge in biomedicine is to connect each human disease with drugs that effectively treat it, and to understand the molecular basis for such drugs' effects.

To solve this problem systematically, the researchers described the effects of drugs and diseases in the common language of "genomic signatures", meaning the full complement of genes that the drugs turn on and off.

The researchers collected gene-expression profiles from cultured human cells treated with 164 bioactive small molecules, including the anti-cancer drug gedunin, estrogen and certain antipsychotics.

They also collected genetic signatures from cells affected by conditions such as diet-induced obesity, Alzheimer's disease, and a drug-resistant form of leukemia.

Using pattern-matching software to mine these data, the researchers identified potential mechanisms of drug action, confirmed previous applications of known drugs, and discovered potential new uses for known drugs.

"This is a powerful discovery tool for the scientific community," said Justin Lamb, the lead author of the Science paper and a senior scientist at the Broad Institute's Cancer programme.

"By analysing just a small fraction of available drugs, we have already confirmed several biological connections between drugs and human disease, and made entirely new ones too."

One of the surprising results emerging from the connectivity map involves gedunin, a plant derivative that, despite a long history of medicinal use, is not well understood molecularly.

Another key finding suggests a new way to overcome drug resistance in cancer, according to the researchers.

Using the connectivity map, another team led by Scott Armstrong, an assistant professor at Harvard Medical School, identified the FDA-approved immunosuppressant drug sirolimus, as a therapeutic candidate for overcoming drug resistance in a form of human leukemia.

Source-IANS
'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/1/2017)... ... March 01, 2017 , ... NYC based Integrated practice Living Well Medical, a ... the addition of Orthopaedic Surgeon Dr. Donald E. Heitman. Dr. Heitman is ... with a Bachelor of Science degree in biology. He then obtained his medical degree ...
(Date:3/1/2017)... ... March 01, 2017 , ... “There is Comfort for the Soul”: a ... author in their all-too-brief time together, and the soul-healing comfort provided by God’s presence ... creation of published author, Jerie A. Tau, a dog-loving medical professional whose work takes ...
(Date:3/1/2017)... ... March 01, 2017 , ... “Marriage...God's Way: Key To One Flesh”: ... To One Flesh” is the creation of published author Cecilia Chiam, a writer who ... Cecilia Chiam‘s new book presents solutions to many marital problems with the guidance ...
(Date:3/1/2017)... Colo. (PRWEB) , ... March 01, 2017 , ... ... to the marijuana industry, today unveiled its Cannabis Compliance Program for Regulatory Agencies. ... medical marijuana industry to provide regulators with internal or outsourced compliance program options, ...
(Date:2/28/2017)... DC (PRWEB) , ... March 01, 2017 , ... Among ... the National League for Nursing, Beverly Malone, PhD, RN, FAAN, has been tapped ... Healthcare, a prestigious biennial list compiled by the Modern Healthcare. She will join her ...
Breaking Medicine News(10 mins):
(Date:3/1/2017)... , Mar 01, 2017 ... Research and Markets ... Partnering 2010 to 2017" report to their offering. ... since 2010 report provides understanding and access to partnering deals and ... The report provides an analysis of partnering deals. The majority of ...
(Date:3/1/2017)... , Mar 01, 2017 ... Research and Markets has announced the addition ... Business Report" report to their offering. The report ... Japan , Europe , ... World. Annual estimates and forecasts are provided for the period 2015 through ...
(Date:3/1/2017)... , March 1, 2017  Integrated Modular ... the design and implementation of pre-fabricated healthcare ... patient room headwalls, seeks to lead the ... higher-quality solutions. Fueled by their ... capable of reducing construction timelines and project ...
Breaking Medicine Technology: