Navigation Links
Genetic Map Reveals How Drugs Fight Diseases: Study

US scientists reported an initial success in building an extensive catalog of information about how drugs affect various healthy and diseased cells. //

This so-called "Connectivity Map" will be able to reveal links among drugs, genes and diseases, the researchers wrote in the latest issue of Science.

The findings, reported Thursday by US scientists and also published in the journal Cancer Cell, may accelerate the search for new drugs to treat diseases, by predicting the molecular actions of novel therapeutic compounds and revealing how existing drugs can be newly applied to treat diseases such as cancer.

A key challenge in biomedicine is to connect each human disease with drugs that effectively treat it, and to understand the molecular basis for such drugs' effects.

To solve this problem systematically, the researchers described the effects of drugs and diseases in the common language of "genomic signatures", meaning the full complement of genes that the drugs turn on and off.

The researchers collected gene-expression profiles from cultured human cells treated with 164 bioactive small molecules, including the anti-cancer drug gedunin, estrogen and certain antipsychotics.

They also collected genetic signatures from cells affected by conditions such as diet-induced obesity, Alzheimer's disease, and a drug-resistant form of leukemia.

Using pattern-matching software to mine these data, the researchers identified potential mechanisms of drug action, confirmed previous applications of known drugs, and discovered potential new uses for known drugs.

"This is a powerful discovery tool for the scientific community," said Justin Lamb, the lead author of the Science paper and a senior scientist at the Broad Institute's Cancer programme.

"By analysing just a small fraction of available drugs, we have already confirmed several biological connections between drugs and human disease, and made entirely new ones too."

One of the surprising results emerging from the connectivity map involves gedunin, a plant derivative that, despite a long history of medicinal use, is not well understood molecularly.

Another key finding suggests a new way to overcome drug resistance in cancer, according to the researchers.

Using the connectivity map, another team led by Scott Armstrong, an assistant professor at Harvard Medical School, identified the FDA-approved immunosuppressant drug sirolimus, as a therapeutic candidate for overcoming drug resistance in a form of human leukemia.

Source-IANS
'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: