Navigation Links
Genetic Link to Adrenal Tumor Revealed

leotides, thereby halting the cell's response to the hormone.

In the study, the patients' tumors were made up of cells that were deficient in the enzyme PDE11A. This enzyme halts cyclic nucleotide production in adrenal cells as well as in other kinds of cells in the body. Because they lacked PDE11A, the patients' adrenal cells had higher levels of cyclic nucleotides. The researchers believe that these higher cyclic nucleotide levels led to the formation of tumors.

The gene for PDE11A contains the information needed to make 4 slightly different forms of the enzyme. The form of the enzyme that was mutated in the patients who took part in the study was found in large amounts in normal adrenal glands and in even larger amounts in normal prostate glands, Dr. Stratakis added. Other forms of PDE11A are found in several other tissues, including the testes, skeletal muscle, and the heart.

Dr. Stratakis noted that although the evidence associating the mutation in the gene for PDE11A to the development of adrenal tumors was very strong, the study was not capable of proving that the mutation actually caused the tumors.

In their article, the researchers wrote that drugs used to treat erectile dysfunction interfere with the functioning of PDE11A. The researchers noted that PDE11A 'is partially inhibited' by the drug tadalafil and 'weakly' inhibited by sildenafil. They added that there are no reports in the medical literature of malfunctioning adrenal glands or increased adrenal cell growth in users of these drugs.

'However, detailed clinical studies addressing this potential complication are currently lacking,' they wrote.

Dr. Stratakis and his colleagues are currently planning studies to determine if differences in the gene for PDE11A might influence an individual's cancer risk.

(Source: Eurekalert)
'"/>




Page: 1 2

Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genetic Link Adrenal Tumor Revealed

(Date:9/4/2015)... ... 04, 2015 , ... FiltersFast.com, the online retail leader in ... passed up. FiltersFast.com, will ship all orders over $50.00 for free. Use ... Take advantage of this promotion now through September 8, 2015. , Filtersfast.com offers ...
(Date:9/3/2015)... Angeles, CA (PRWEB) , ... September 03, 2015 , ... ... patients as to the best practices when preparing for a bariatric procedure, some patients ... a procedure. Apart from the basic instructions typical for many types of surgery that ...
(Date:9/3/2015)... ... September 03, 2015 , ... William Mattar Law Offices is known ... this does not stop at any certain demographic or segment of the population. ... thirty-, fifteen- and ten-second TV commercials. , The closed captioning will allow people with ...
(Date:9/3/2015)... ... September 03, 2015 , ... Mayo School of Graduate ... Center for Hospice Care (CHC) for physician Hospice and Palliative Medicine Fellowship ... part of fulfilling their requirements for obtaining national Board Certification in Hospice and ...
(Date:9/3/2015)... ... September 03, 2015 , ... Results ... Center for Healthcare Research and Policy Analysis has found physician leadership development training ... While 47 percent of respondents said their organizations conduct some kind of physician ...
Breaking Medicine News(10 mins):Health News:FiltersFast.com Wows with a Long Labor Day Weekend Shipping Offer 2Health News:Dr. Feiz and Associates Answer August's ‘Patient Submitted Question of the Month’: “How Can I Prepare for Weight Loss Surgery” 2Health News:Law Firm Focused on “Helping People” Continues to Expand on Vision 2Health News:Physicians from Mayo Clinic and Indiana University to Complete Hospice & Palliative Medicine Training at Center for Hospice Care 2Health News:Survey finds growing movement for physician leadership training 2Health News:Survey finds growing movement for physician leadership training 3
... Coalition of patients, practitioners and employers urges ... deployment of interoperable health,information technology, WASHINGTON, ... co-chaired by former Senator John Breaux and ... Eshoo,and Mike Rogers for introducing legislation that ...
... The Pennsylvania,Department of Health today is emphasizing ... for consumers not to eat Banquet brand and,store ... possible,Salmonella contamination., "Federal officials have already shared ... ensure Pennsylvanians are taking the,appropriate measures to protect ...
... Guttmacher,Institute,s latest report on world abortion rates is ... W. Mosher. The,study, just released today, argues that ... developing countries., Accurate numbers are impossible to ... illegal. Says Mosher: "Neither,Guttmacher nor anyone else knows ...
... have discovered a key protein that controls how stem ... move limbs, or smooth muscle cells that support blood ... Proceedings of the National Academy of Sciences (PNAS). ... of muscle types in the human fetus, but also ...
... Ohio, Oct. 10 PartsSource, the nation,s leading,supplier ... &,CEO, A. Ray Dalton has been selected as ... Business" award. This honor is given to,executives who ... new,businesses throughout their professional career. "I am ...
... ... geographically, WILMINGTON, N.C., Oct. 10 ... as senior vice,president of clinical operations for North America and Simon ... Colvin joins PPD from Eli Lilly and Company where he most ...
Cached Medicine News:Health News:Health IT Now! Coalition Applauds Representatives Eshoo and Rogers for Introducing Health IT Legislation 2Health News:Salmonella Outbreak Traced to Banquet and Store Brand Frozen Pot Pies 2Health News:PRI Criticizes Guttmacher Report 2Health News:Study reveals how stem cells decide to become either skeletal or smooth muscle 2Health News:Study reveals how stem cells decide to become either skeletal or smooth muscle 3Health News:Study reveals how stem cells decide to become either skeletal or smooth muscle 4Health News:Study reveals how stem cells decide to become either skeletal or smooth muscle 5Health News:PPD Names VPs for North America and Asia 2Health News:PPD Names VPs for North America and Asia 3
(Date:9/4/2015)... DUBLIN , Sep. 04, 2015 /PRNewswire/ ... ( http://www.researchandmarkets.com/research/dvzsqg/investigation ) has announced the addition ... Sodium Hyaluronate Market, 2010-2019" report to ... a long-chain polymer containing repeating disaccharide units ... synovial fluid and cartilage matrix, sodium hyaluronate ...
(Date:9/3/2015)... 2015 Report Details What can ... are going to grow at the fastest rates? Visiongain,s ... assessing data, trends, opportunities and prospects there. ... Discover the most lucrative areas in the industry and ... assess forecasted sales at overall world market and regional ...
(Date:9/3/2015)... Sept. 3,  2015 About artificial ... devices, which are implanted or integrated into ... These include artificial heart, kidney, pancreas, and ... (polyurethane, polysulfone, and porous polypropylene), biologics, ceramics, ... organs. These organs are incorporated with different ...
Breaking Medicine Technology:Investigation Report on China's Sodium Hyaluronate Market 2015 2Ophthalmic Devices Market Forecast 2015-2025: Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 2Ophthalmic Devices Market Forecast 2015-2025: Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 3Ophthalmic Devices Market Forecast 2015-2025: Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 4Global Artificial Organ Market 2015-2019 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: