Navigation Links
Genetic Fingerprints Identify Brain Tumors' Origins

Genetic fingerprints that reveal where a brain cell came from remain distinct even after the cell becomes a brain // tumor, an international coalition of scientists will report in the February 1 issue of Cancer Research.

The finding adds a new layer of complexity to the quest to understand the causes of childhood brain cancers, according to senior author David H. Gutmann, M.D., Ph.D., the Donald O. Schnuck Family Professor of Neurology at Washington University School of Medicine in St. Louis and co-director of the neuro-oncology program at the Siteman Cancer Center.

"Our findings suggest that brain tumors arising in different regions may be genetically distinct as a consequence of their unique cellular origins," Gutmann says. "This is yet another factor we need to consider when trying to understand how pediatric brain tumors form."

Researchers use information about tumor origins to develop new tests and treatments for the tumors. Brain tumors are the leading cause of cancer-related death in children, and the most common childhood brain tumor is the pilocytic astrocytoma (PA). Approximately 15 percent of all PAs are linked to neurofibromatosis 1 (NF1), a genetic condition that causes childhood brain tumors and is a primary focus of Gutmann's research. However, the genetic basis for the majority of PAs is unexplained.

In the new study, Gutmann led six laboratories in the most detailed genetic analysis of PAs to date. "We were hoping to identify genes that contribute to the formation of these tumors and find indicators that might help us predict which tumors will be relatively well-behaved and which will be more aggressive," Gutmann says.

Previous studies have failed to produce any solid leads on the genetic alterations that predispose children to PAs.

"It should be recognized that the genetic alterations in this tumor may be very subtle," Gutmann notes. "When we looked at gene activity levels in the tumo rs as a function of brain location, though, a very interesting pattern began to emerge."

Cells in different parts of the brain carry the same genes, but they also contain factors that modify the use of those genes, suppressing some genes and activating others to allow the cells to take on specialized characteristics as the brain matures. These changes in gene activity levels are called changes in gene expression.

The researchers found that tumors arising in different regions of the brain retain distinct patterns of gene expression. These patterns provided genetic fingerprints or bar codes for the location of PAs, as well as for another glial cell tumor called an ependymoma. In addition, scientists also detected these distinct patterns of expression in normal glia and stem cells from these brain locations, suggesting that genetic fingerprints can be used to identify the potential origins of brain tumors.

"There's been a movement in recent years to link normal brain development to pediatric neuro-oncology, and these findings affirm that as a necessary approach," Gutmann says. "We won't fully understand the causes of pediatric brain tumors until we consider them in the context of factors that shape the development and specialization of different brain regions."



Source-Bio-Bio Technology
SRI
'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/20/2017)... ... 2017 , ... Recognising that in today’s busy world consumers ... positive results in just three weeks. Setting the groundwork for a healthier lifestyle, ... into hectic work and family schedules, participants can lose up to 15lbs during ...
(Date:9/20/2017)... ... September 20, 2017 , ... Ron Norman, CEO ... marketers this week about the value of senior executives, pointed to a quote ... in business has brought us to the present and will lead us into ...
(Date:9/20/2017)... ... ... “Monique”: is the story of Monique, whose mother’s deteriorating physical condition forces the ... has owned four beauty salons and written a book regarding the author’s success in ... , “The doctor’s office was only three blocks away, and she could walk it, ...
(Date:9/19/2017)... ... September 19, 2017 , ... Trusted debt-reduction firm CreditAssociates, LLC has ... translating to in excess of $835 million in resolved debt for its clients. , ... are some of the categories of debt settled by the company. With more than ...
(Date:9/19/2017)... ... September 19, 2017 , ... The ... Canyon Ranch to its recently formed Corporate Roundtable, a group of individuals ... and a sustainable world. , Canyon Ranch is a unique collection of lifestyle-based ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... Sept. 18, 2017 EpiVax, Inc. ... bioinformatics and immune engineering, today announced a ... A (H7N9) vaccine. ... seasonal influenza and presents a challenge for ... exposure to be effective. Using state-of-the-art bioinformatics and ...
(Date:9/9/2017)... WASHINGTON , Sept. 8, 2017 ... Mobile MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, ... to Washington, D.C. offering free MRI brain scans to the public.Where:  ... – will be parked at 501 K Street NW, Washington, D.C.What:BTF brings ...
(Date:9/7/2017)... Texas , Sept. 7, 2017 ... science focused on fulfilling the promise of precision ... further validate the benefits of its molecular profiling ... study utilized comprehensive genomic profiling plus (CGP+) with ... individual patient,s tumor on a molecular level, leading ...
Breaking Medicine Technology: