Navigation Links
Genetic Factors Behind Mosquitoes Resistance to Malaria Identified

Researchers at UT Southwestern Medical Center have discovered the genetic factors that make some mosquitoes resistant to malaria.

The researchers say that TEP1 protein in the mosquitos immune system is the key to their finding.

When a mosquito is infected with a parasite that causes malaria, a biochemical reaction is triggered that physically transforms TEP1 into an active state capable of grabbing on to the parasites surface and targeting it for termination, they say.

In a study, reported online in the Proceedings of the National Academy of Sciences, the researchers used a method called X-ray crystallography to uncover TEP1s three-dimensional structure.

It was found that the genetic differences between mosquitoes resistant to or susceptible to malarial parasite manifest mainly in a region of the TEP1 protein called the warhead, the portion that grabs the parasite.

TEP1 is a scout that finds the enemy, in this case malarial parasites, then plants a homing signal on the enemy and calls in the air strike, said lead study author Dr. Richard Baxter, a postdoctoral researcher in biochemistry at UT Southwestern.

He said that the understanding as to how some mosquitoes are able to fend off malaria might someday lead to reducing or even eliminating the insects capacity to transmit the devastating disease.

We have been trying to cure people of malaria for over a century. Only recently have people started to think about curing mosquitoes of malaria, said Dr. Baxter, who also is a research associate with the Howard Hughes Medical Institute at UT Southwestern.

Nobel laureate Dr. Johann Deisenhofer, who is senior author of the study, said that the new findings were the indication that just like humans, mosquitoes also want to get rid of malaria.

This finding opened my eyes to the fact that mosquitoes are almost as unhappy about malaria as we are. They try to get rid of it. Dr. Johann Deisenhofer, who was awarded the 1988 Nobel Prize in chemistry for using X-ray crystallography to describe the structure of a protein involved in photosynthesis.

The researchers are now planning to genetically manipulate the warhead to study its binding properties. Dr. Baxter says that further research is needed to determine what other elements of the mosquitos immune system are activated once TEP1 binds to an invader.


'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... insurance and financial consultation services to residents in the Sacramento/Folsom region, is initiating ... Chance treatment facility. , The Another Choice Another Chance treatment center in Sacramento ...
(Date:12/7/2016)... ... , ... A. Kevin Spann Insurance, a New York-based firm offering insurance and ... a charity drive to raise funds that will benefit the Marine Corps League. , ... Navy FMF Corpsmen. Working closely with the MCL, the A. Kevin Spann team plans ...
(Date:12/7/2016)... Chicago, IL (PRWEB) , ... December 07, 2016 , ... ... giving back this holiday season by donating a portion of proceeds to two local ... North Chicago Animal Control & Friends is a team of authorized and ...
(Date:12/7/2016)... CA (PRWEB) , ... December 07, 2016 , ... The ... the holidays and winter seasons. One major study analyzing heart attacks among 138,602 ... to August of a given year. We would all agree of course–no time of ...
(Date:12/7/2016)... CT (PRWEB) , ... December 07, 2016 , ... ... Integrated Infertility and Wellness (IFW) Program at Reproductive Medicine Associates of Connecticut (RMACT). ... now has a team of three acupuncturists to help patients realize their family ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... LONDON , Dec. 7,2016  Based ... drug delivery industry, Frost & Sullivan recognizes ... Frost & Sullivan Award for Enabling Technology ... plug the loopholes in traditional drug delivery ... and liquid microneedle-based drug delivery technologies, Memspatch ...
(Date:12/7/2016)... 7, 2016  Lannett Company, Inc. (NYSE: LCI ) ... Markets 2016 Prescription for Success Healthcare Conference on December 14, 2016 ... New York City . In addition, the ... Guggenheim Securities 4 th Annual Boston Healthcare Conference taking place ... ...
(Date:12/6/2016)... YORK , Dec. 6, 2016 Radioisotopes ... nucleus. Radioisotopes are produced either by using nuclear research ... in the form of alpha, beta or gamma when ... emitted are used in Nuclear medicine, specifically in medical ... provide diagnostic information about a human body,s functioning. Radiotherapy ...
Breaking Medicine Technology: