Navigation Links
Genetic Cause For Farsightedness Discovered

Researchers from Johns Hopkins had discovered the gene expression responsible for extreme farsightedness in people.

The researchers report that nanophthalmos, or "dwarf eye," a rare, potentially blinding disorder, is caused // by an alteration in a gene called MFRP that helps control eye growth and regulates the organ's shape and focus. The study is described in the July issue of the journal Proceedings of the National Academy of Sciences.

As the child grows and gains more visual experience, the eye adjusts its focus by growing, which changes the distance between the lens and the retina, the light-detecting layer of cells at the back of the eye. Due to natural genetic mutations, some eyes stop growing too soon, causing farsightedness.

In the case of nanophthalmos, a mutation in MFRP completely wipes out the function of the protein coded for by the gene. In people with this condition, the retina is too close to the lens, but the lens and cornea, the eye's outermost layer, are of normal size and shape. Eyes with nanophthalmos still work quite well, despite these complications. But the disease's secondary complications later in life, including glaucoma or detached retina, are far more severe and can lead to complete blindness.

One such patient with nanophthalmos, an Amish-Mennonite woman who was blind in one eye, came to the Wilmer Eye Institute in 1998 for treatment. By reconstructing the woman's family tree, the researchers discovered that several living relatives also suffered from nanophthalmos, and four deceased relatives had been part of the classic Johns Hopkins Bloomberg School of Public Health study in the 1970s that helped define the disease as genetic.

In the study, the researchers examined the woman's DNA for possible gene mutations causing nanophthalmos. The research team successfully mapped the MFRP gene mutation in humans and discovered that the protein was completely missing from nanophthalmos pa tients. In a normal human eye, the MFRP protein is located on the surface of the retinal pigment epithelium (RPE), which is located beneath the retina and helps maintain photoreceptors, the eye's light-detecting cells. Blindness occurs when these cells die after detachment of the retina from the RPE.

Researchers hope the information gained from his study will open doors to correcting other types of severe refractive error, not only farsightedness, but also nearsightedness.

Source: Newswise
'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... Louis, MS (PRWEB) , ... December 08, 2016 , ... ... that serve commercial and residential clients in and around the Hancock County area, is ... for the Hancock County Food Pantry. , The Hancock County Food Pantry has worked ...
(Date:12/8/2016)... ... December 08, 2016 , ... Bill Mull Agencies, a ... in and around central Kansas, is joining the Youth Horizons organization for a ... , Headquartered in Wichita, Youth Horizons works to empower area children from unstable, ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... will have the unique opportunity to get hands-on experience in an emergency ... students an immersive experience to gain invaluable, real-life medical skills that are critical ...
(Date:12/7/2016)... ... December 07, 2016 , ... Kenall Manufacturing, a leader in sealed healthcare lighting ... MPCNGX is a multi-function, sealed, LED luminaire that meets the needs of everyone in ... it’s needed. , A 2’ x 4’ model features four modes: reading, ...
(Date:12/7/2016)... LA (PRWEB) , ... December 07, 2016 , ... ... used to treat wrinkles and deep lines by smoothing and tightening the skin ... invasive techniques out there to address facial aging with very little downtime, Silhouette ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... Research and Markets has announced the addition of the ... Application, Usability - Forecast to 2025" report to their offering. ... , , ... grow at a CAGR of around 3.2% from 2015 to 2025. ... advancements in extracellular microelectrode arrays and intracellular microelectrodes, research in left-to-right ...
(Date:12/8/2016)... 2016 Bodycad announced it has been ... accuracy, reproducibility and speed for 3D constructs via ... bone orthopaedic applications. These patents are critical to ... restorations based on each patient,s distinct anatomy. ... harnesses the world,s first suite of orthopaedic CAD/CAM ...
(Date:12/8/2016)... , Dec. 8, 2016  A new study ... that the use of opioid therapy to treat chronic ... the likelihood of more harmful consequences, including death. ... M.D., and Zankhana Mehta , M.D., authored the ... on chronic opioid therapy. The study was published in ...
Breaking Medicine Technology: