Navigation Links
Genes to Extend Longevity Discovered

Calorie restriction seems to be the key to extend the lifespan of many species through Sir2 gene.//

Researchers from Harvard Medical School, Boston and University of California, Davis, screened for genes that could increase yeast lifespan via Sir2 gene. According to the study published today in the advance online edition of Science, “Yeast and Drosophila lacking the Sir2 gene do not live longer when subjected to calorie restriction, suggesting that Sir2 underlies this lifespan extension.” “However,” they say, “there is increasing evidence that the situation is not so simple.”

"We think these new Sir2 genes are as important as any longevity genes discovered so far," said molecular biologist David Sinclair, director of the Paul F. Glenn Laboratories for Aging Research at Harvard Medical School and co-author of the new study. "There is a growing realization from the aging field that we might finally understand how to control certain aspects of the aging process and one day have drugs that can fight some of the disabilities the process causes."

There has been some controversy over the role of the gene Sir2 in the ability of caloric restriction to extend yeast lifespan and some recent work suggests that caloric-restriction-induced lifespan extension may not involve Sir2. The results also show that Hst2 is responsible for Sir2-independent lifespan extension by calorie restriction, and that it does so by suppressing ribosomal DNA recombination, which is the same mechanism by which Sir2 functions.

Sinclair's research group have earlier reported in the journal Nature about the first genetic link between environmental stresses and longer life. Triggered by low salt, heat, or extreme calorie restriction, a yeast "master longevity regulator" called PNC1 stimulated Sir2 activity. This work was done by Harvard graduate student Dudley Lamming, demonstrates that PNC1 regulates the whole SIR2 family of genes, suggesting that a h uman PNC1 gene might protect against diseases of aging such as cancer, heart disease and diabetes.

This work was supported by the National Institute on Aging, the Paul F. Glenn Foundation, and the Ellison Medical Foundation and further supported by fellowships and training grants from the American Federation for Aging Research and the National Eye Institute.


Leah Gourley
Harvard Medical School

Further Information on Genetics from Medindia
An educational process that seeks to assist affected individuals and other individuals at risk of getting an inherited condition to understand the nature of the genetic disorder, its transmission and the options open to them in management and family planning - ( Kelly, 1998).

Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Genes for lung disease
3. Genesis of SUPAC
4. Genes for Vision discovered
5. Genes Found To Help Leukemia Treatment
6. Cardiac Valve Disease Linked To Genes
7. Genes Linked To Cigarette Addiction
8. Genes from saliva may predict oral and breast cancer
9. Genes More Important Than Exercise for Bad Cholesterol
10. Genes responsible for social behavior of us
11. Genes responsible for cancer in women associated with increased cancer risk in men
Post Your Comments:

(Date:6/27/2016)... ... , ... TherapySites, the leading website and online ... Counseling Association. This new relationship allows TherapySites to continue to extend their ... benefits and promotional offers. , "TCA is extremely excited about this new partnership, ...
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
(Date:6/24/2016)... Dublin - ... " Global Markets for Spectroscopy Equipment" report ... This report focuses on the global market of ... applications in various applications. The report deals with spectroscopy ... industries: pharmaceutical and biotechnology, food and beverage, and environmental ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
Breaking Medicine Technology: