Navigation Links
Genes That Were Responsible For The Cause Of Blindness Identified

Scientists have identified those two genes that were responsible for the cause of blindness that affects millions of older people // throughout the world and they added that the new development could pave way for new treatments.

Nearly three-quarters of people in the world suffer from age-related macular degeneration (AMD) a most common cause of blindness. AMD is marked by a progressive loss of central vision due to degeneration of the macula - a region of the retina responsible for fine, central vision.

Researchers at New York's Columbia University studied 1,300 people and found that this common cause of blindness was linked to just two genes - Factor H and Factor B. While Factor H is an inhibitor of the immune response to infection, Factor B is an activator, the online edition of BBC News reported.

"I am not aware of any other complex disorder where nearly 75 percent of genetic causality has been identified," lead researcher Rando Allikmets said.

Factor H controls the production of a protein that helps shut down the body's immune response to infection once it has been successfully fought off.

People with these inherited variants of Factor H are less able to control inflammation caused by infectious triggers, which may spark AMD in later life, they said.

The researchers found 74 percent of the people with AMD had either the Factor H or Factor B risk factor or both - but no protective variants of either gene.

"These findings are significant because they absolutely confirm the roles of these two genes and, consequently, the central role of a specific immune response pathway, in the development of AMD," Allikmets said.

"In just a few short years, we've gone from knowing very little about what causes AMD to knowing quite a lot. We now have clear targets for early therapeutic intervention," Allikmets said.

The researchers are now searching for the specific t riggers that set off the immune response, and subsequent inflammation.

--Edited IANS

Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Genes for lung disease
3. Genesis of SUPAC
4. Genes for Vision discovered
5. Genes Found To Help Leukemia Treatment
6. Cardiac Valve Disease Linked To Genes
7. Genes Linked To Cigarette Addiction
8. Genes from saliva may predict oral and breast cancer
9. Genes More Important Than Exercise for Bad Cholesterol
10. Genes responsible for social behavior of us
11. Genes to Extend Longevity Discovered
Post Your Comments:

(Date:10/13/2015)... , ... October 13, 2015 , ... ... communities, and the Florida Apartment Association (FAA) has partnered with the Florida Department ... meet the demand. , The FAA Smoke-Free Multifamily Housing Program launched last ...
(Date:10/13/2015)... ... , ... Just under three months ago, eMarketing Concepts forever changed ... effectively offering all of their services for just a buck in the first month. ... phone calls from interested buyers. As a genuine one-stop-shop for internet marketing, EMC has ...
(Date:10/13/2015)... CA (PRWEB) , ... October 13, 2015 , ... ... announced the release of a new PDF automation tool to batch conversions ... and business mandates with 100% document fidelity. , CADConverter eliminates the complexity requirement ...
(Date:10/13/2015)... ... October 13, 2015 , ... The Bill Howe Family of Companies ... offering expert reconstruction and flood remediation services. Family-owned and operated for 35 years, they ... the Best San Diego plumber two years in a row from the Union Tribune ...
(Date:10/13/2015)... Somerset, N.J. (PRWEB) , ... October 13, 2015 ... ... advanced delivery technologies and development solutions for drugs, biologics, consumer health and animal ... Science and Technology, and will lead a new, dedicated global team of drug ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... -- Given the intricacy of the anatomy and ... an ophthalmic drug effectively to a specific ocular site. Several ... delivery. These include dilution of a drug by tears, clearance ... drug permeation issues with respect to the cornea, sclera and ... is lost due to the aforementioned barriers. --> ...
(Date:10/12/2015)... WASHINGTON , Oct. 12, 2015  Former White House ... Press Secretary for the House Narcotics Committee, Robert Weiner ... "Rewriting Drug Policy." The two emphasize that this is now ... Clinton to Jeb Bush , Carly Fiorina ... Sordello cite the newest federal statistics, which they call "a ...
(Date:10/12/2015)... Corporation (NASDAQ: LMNX ) today announced that it expects ... 2015 on Monday, November 2, 2015. A press release announcing ... trading. --> --> ... highlights and financial results for the third quarter ended September ... time. . Simply log on to ...
Breaking Medicine Technology: