Navigation Links
Genes Identified To Protect Heart Muscles

According to the study conducted by the Queen's University researchers it was found that by appreciating how genes work to protect the aortic muscle new treatment// options can be developed to help patients suffering from arteriosclerosis.

It is one of the major causes of heart attack and stroke. The study, released July 14 by the American Heart Association, found that a gene called heme oxygenase-1 (HO-1) markedly protects the arteriosclerois-prone human aortic smooth muscle cells from death after exposure to high concentrations of reactive oxygen species (ROS). ROS are a natural by-product of the body's metabolism of oxygen and are known by scientists for their signaling role in cellular activity.

The findings revealed that HO-1 exerted these remarkable protective effects by cooperating with another protective gene, Akt. The protective effect of HO-1 was dependent on the activation of Akt and vice-versa, indicating that these two protective genes work co-dependently to exert their beneficial effects. ‘It appears that these two genes act as dance partners in the complex tango of cellular protection, with neither one wanting to assume the lead role,’ says the study's lead author Luis G. Melo, Associate Professor of Physiology and Canada Research Chair in Molecular Cardiology at Queen's.

He says the findings point to a new therapy for preventing clogging in the arteries to avoid heart attacks and strokes. Smooth muscle cells make up the wall of blood vessels and are the prime target for development of the plaque that causes arteries to harden. The smooth muscle cells provide stability to the plaque, thereby preventing it from rupturing and causing clogging of the blood vessels (thrombosis). The major cause of plaque rupture is the loss of smooth muscle cells due to cell death caused by an excess hydrogen peroxide.

In the study, funded by CIHR and the Heart and Stroke Foundation of Ontario, investigators used a harmless virus t o express the HO-1 protein in the cells. The cells were then exposed to high levels of hydrogen peroxide and their survival was monitored over 48 hours. Cells over-expressing HO-1 were seen to have a remarkable ability to escape apoptosis, a form of cell suicide, even after being exposed to toxic levels of hydrogen peroxide. ‘A strategy aimed at protecting smooth muscle from undergoing apoptosis is a logical therapeutic target for plaque stabilization. One such approach may heed our findings and use gene therapy to deliver the HO-1 gene to the atherosclerotic plaques,’ says Dr. Melo.

‘Our laboratory is actively pursuing the development and preclinical testing of these new gene therapies using sophisticated viral vector systems, which are highly responsive to the pathological conditions of the plaque itself. Although the possibility of using these experimental therapies in the clinical setting is years away, we believe that we are in the right path, and one worth pursuing, considering the devastating socio economic effects of this disease.’ Protection of Human Vascular Smooth Muscle Cells From H202-induced Apoptosis through Functional Codependence between HO-1 and AKT will appear in the September issue of Arteriosclerosis, Thrombosis and Vascular Biology, the official journal of the Council in Arteriosclerosis, Thrombosis and Vascular Biology of the American Heart Association.

Source: Eurekaert
'"/>




Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Genes for lung disease
3. Genesis of SUPAC
4. Genes for Vision discovered
5. Genes Found To Help Leukemia Treatment
6. Cardiac Valve Disease Linked To Genes
7. Genes Linked To Cigarette Addiction
8. Genes from saliva may predict oral and breast cancer
9. Genes More Important Than Exercise for Bad Cholesterol
10. Genes responsible for social behavior of us
11. Genes to Extend Longevity Discovered
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2017)... ... 22, 2017 , ... A cylindrical “pipeline” used for treating ... reach ones, according to the results of a clinical trial announced Wednesday. , ... Ricardo A. Hanel, MD, PhD, neurovascular surgeon with Baptist Health and Lyerly Neurosurgery ...
(Date:2/22/2017)... ... 22, 2017 , ... Using the power of the internet, IdrisArkette.com has managed ... a period of just 24 months, thousands of individuals interested in a medical procedure ... , “The internet is not getting quieter. In fact it’s becoming noisier by the ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... of issues related to spine practices, is featuring Michigan neurosurgeon Jay Jagannathan, M.D., ... as one of a small number of neurosurgeons in Michigan performing minimally invasive ...
(Date:2/22/2017)... ... February 22, 2017 , ... Forty-five ... of those report that family members or friends have also commented about their ... hearing loss wear hearing aids. One reason, suggested by 89 percent of American ...
(Date:2/22/2017)... ... ... Social media marketing is transitioning from a singular person activity to a ... into this insight and more in its latest episode of its Brains Over Brawn ... with social media strategist and partner of the digital firm Med|Ed Digital Jessica Columbo. ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 22, 2017 Research and Markets has ... Pipeline Review, 2016" report to their offering. ... Dermatological conditions ... and approximately one-third of the US population suffers from at ... majority of the dermatology market has remained saturated with established ...
(Date:2/22/2017)... and PUNE, India , February ... report published by Allied Market Research, titled, "Radiology Information System ... Opportunity Analysis and Industry Forecast, 2014-2022," the radiology information system ... projected to reach $941 million by 2022, growing at a ... information systems segment held over three-fifths share of the total ...
(Date:2/22/2017)... , February 22, 2017 ... the Dow Jones Industrial Average, and the S&P ... out of nine sectors ended Tuesday,s trading session ... sentiment, Stock-Callers.com assessed the following Medical Instruments & ... (NASDAQ: TNDM), C. R. Bard Inc. (NYSE: BCR), ...
Breaking Medicine Technology: