Navigation Links
Genes Associated With Limb Development is More Primitive Than Believed

A new study by a University of Chicago researcher has revealed that fish possessed the genes associated with helping to grow hands and feet (autopods) much before animals with limbs (tetrapods) came onto the scene about 365 million years ago.

Lead author of the study in the Nature, Dr Marcus Davis said, the findings overturned a long held, but much debated theory that limb acquisition was a novel evolutionary event and required the descendents of lobed-fin fish to dramatically alter their genes to adapt their bodies to their new environments of streams and swamps.

An autopodial-like pattern of Hox gene expression in the fins of a basal actinopterygian fish, shows that the genetic and developmental toolkit that builds limbs with fingers and toes was around long before the acquisition of limbs, and that this toolkit exists in some primitive form in a living primitive bony fish, the paddlefish. We found that the genetic capability seen in tetrapods to build limbs is present in even more primitive fish," said Dr. Davis.

For their study, Dr Davis and his colleagues used the paddlefish as a proxy for a more primitive ancestor, as these fish have an elaborate fin skeletal pattern similar to that seen in more primitive vertebrates such as sharks and many fossil fish.

The researchers studied the development of paddlefish fins to test whether the genes activated to make hands and feet in tetrapods were different from the genes activated to make fish fins.

They looked at Hox geneswhich play a vital role in limb developmentin the pectoral fins of paddlefish, and to track where the Hox genes are active in the fin, inserted molecular markers into them.

Findings revealed that the activity pattern in the pectoral fins was very much similar to the genes responsible for the development of tetrapod limbs.

Tetrapods have a second phase of Hox gene expression that happens later in developm ent. During this second phase, hands and feet develop, and the scientists found this was present in the paddlefish.

In other words, the pattern of gene activity long thought to be unique to vertebrates with hands and feet is much more primitive, said Dr. Davis.


'"/>




Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Genes for lung disease
3. Genesis of SUPAC
4. Genes for Vision discovered
5. Genes Found To Help Leukemia Treatment
6. Cardiac Valve Disease Linked To Genes
7. Genes Linked To Cigarette Addiction
8. Genes from saliva may predict oral and breast cancer
9. Genes More Important Than Exercise for Bad Cholesterol
10. Genes responsible for social behavior of us
11. Genes to Extend Longevity Discovered
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/16/2017)... , ... January 16, 2017 , ... ... been appointed Chief Executive Officer of the medical device company, effective immediately. , ... Robert Storey. “Kevin has a strong track record in medical device market ...
(Date:1/15/2017)... ... 2017 , ... Going above and beyond the practical impact ... communities around the world by offering the Gensuite team and their services to ... members to become involved in a cause that is bigger than themselves and ...
(Date:1/15/2017)... ... 15, 2017 , ... "On Tour is a music themed slideshow production package ... Christina Austin - CEO of Pixel Film Studios. , On Tour’s new slide ... and animation of their slideshows. Place each slide on top of another slide or ...
(Date:1/15/2017)... ... January 15, 2017 , ... The Gravity Vault Indoor Rock Climbing Gym is ... wraps up on the 14,000+ square foot climbing gym, the owners anticipate to open ... in New Jersey and two in New York. With this being its first location ...
(Date:1/14/2017)... ... January 13, 2017 , ... According to a ... Mediterranean diet may lower the risk of type 2 diabetes, Alzheimer’s, and cardiovascular ... health and wellness benefits linked to a Mediterranean diet are only some of ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... SAN FRANCISCO, Calif. , Jan. 16, 2017 /PRNewswire/ ... that on January 3, 2017 and January 16, 2017 ... the grant of inducement stock options to purchase an ... new employees. These awards were granted pursuant to the ... inducement material to the new employees entering into employment ...
(Date:1/16/2017)... , Jan. 16, 2017 CBDRx, the world,s ... amounts of phyto-nutrient rich hemp extract to Veteran,s groups ... of their proprietary hemp extract to Veteran,s groups across ... best hemp company in the world and through their ... nutritious, full spectrum phyto-nutrient rich hemp extract available. ...
(Date:1/15/2017)... 16, 2017 Le conseil d,administration de ... de collagène pour la régénération de tissus humains, annonce la ... directeur général avec effet immédiat. ... Bill est un dirigeant expérimenté à ... postes de gestion générale et de direction au sein de ...
Breaking Medicine Technology: