Navigation Links
Genes Associated With Limb Development is More Primitive Than Believed

A new study by a University of Chicago researcher has revealed that fish possessed the genes associated with helping to grow hands and feet (autopods) much before animals with limbs (tetrapods) came onto the scene about 365 million years ago.

Lead author of the study in the Nature, Dr Marcus Davis said, the findings overturned a long held, but much debated theory that limb acquisition was a novel evolutionary event and required the descendents of lobed-fin fish to dramatically alter their genes to adapt their bodies to their new environments of streams and swamps.

An autopodial-like pattern of Hox gene expression in the fins of a basal actinopterygian fish, shows that the genetic and developmental toolkit that builds limbs with fingers and toes was around long before the acquisition of limbs, and that this toolkit exists in some primitive form in a living primitive bony fish, the paddlefish. We found that the genetic capability seen in tetrapods to build limbs is present in even more primitive fish," said Dr. Davis.

For their study, Dr Davis and his colleagues used the paddlefish as a proxy for a more primitive ancestor, as these fish have an elaborate fin skeletal pattern similar to that seen in more primitive vertebrates such as sharks and many fossil fish.

The researchers studied the development of paddlefish fins to test whether the genes activated to make hands and feet in tetrapods were different from the genes activated to make fish fins.

They looked at Hox geneswhich play a vital role in limb developmentin the pectoral fins of paddlefish, and to track where the Hox genes are active in the fin, inserted molecular markers into them.

Findings revealed that the activity pattern in the pectoral fins was very much similar to the genes responsible for the development of tetrapod limbs.

Tetrapods have a second phase of Hox gene expression that happens later in developm ent. During this second phase, hands and feet develop, and the scientists found this was present in the paddlefish.

In other words, the pattern of gene activity long thought to be unique to vertebrates with hands and feet is much more primitive, said Dr. Davis.


'"/>




Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Genes for lung disease
3. Genesis of SUPAC
4. Genes for Vision discovered
5. Genes Found To Help Leukemia Treatment
6. Cardiac Valve Disease Linked To Genes
7. Genes Linked To Cigarette Addiction
8. Genes from saliva may predict oral and breast cancer
9. Genes More Important Than Exercise for Bad Cholesterol
10. Genes responsible for social behavior of us
11. Genes to Extend Longevity Discovered
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... December 07, 2016 , ... When it came time to blow out his candles on his ... the Pediatric Heart Transplant team at Joe DiMaggio Children’s Hospital surprised his family ... hospital’s 30th heart transplant recipient. , “He was playing at home, when we got ...
(Date:12/7/2016)... PA (PRWEB) , ... December 07, 2016 , ... One ... regular changing of the securement tape is painful for her. "This is why the ... to patients’ heads," she said. , They then created a prototype of the patent-pending ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Honolulu cosmetic and ... website, which launched October 17, 2016, features comprehensive information regarding a wide range ... Visitors and patients can discover the latest clinical dermatology treatments for medical skin ...
(Date:12/7/2016)... ... , ... The medical profession is well aware that heart attacks do indeed ... heart attacks among 138,602 people recorded a 35% higher number of heart attacks in ... of course–no time of year is a good time for a heart attack! In ...
(Date:12/7/2016)... ... December 07, 2016 , ... “The Road To Restoration”: ... trial, not a one hour a week showing of hands. “The Road To Restoration” ... begins, “Perhaps you are familiar with the brass ring that you could reach out ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... 2016   Arena Pharmaceuticals, Inc. (NASDAQ: ... enrollment in the ralinepag phase 2 trial.  Ralinepag is ... pathway for the treatment of pulmonary arterial hypertension (PAH). ... "This marks an important step in the ... focus on our pipeline," said Amit Munshi , ...
(Date:12/7/2016)... Conn. , Dec. 7, 2016 According to ... in more than one-third (38%) of patients with non-small cell ... epidermal growth factor receptor (EGFR) genetic mutation status. The findings ... ( LBA ID #6067 #P3.02b ) at the ... Vienna, Austria . The survey results revealed ...
(Date:12/7/2016)... 7,2016  Based on its recent analysis ... & Sullivan recognizes Nemaura Pharma Limited with ... for Enabling Technology Leadership. Nemaura Pharma,s transdermal ... traditional drug delivery technologies, especially in delivering ... delivery technologies, Memspatch and Micropatch respectively, facilitate ...
Breaking Medicine Technology: