Navigation Links
Genes Associated With Limb Development is More Primitive Than Believed

A new study by a University of Chicago researcher has revealed that fish possessed the genes associated with helping to grow hands and feet (autopods) much before animals with limbs (tetrapods) came onto the scene about 365 million years ago.

Lead author of the study in the Nature, Dr Marcus Davis said, the findings overturned a long held, but much debated theory that limb acquisition was a novel evolutionary event and required the descendents of lobed-fin fish to dramatically alter their genes to adapt their bodies to their new environments of streams and swamps.

An autopodial-like pattern of Hox gene expression in the fins of a basal actinopterygian fish, shows that the genetic and developmental toolkit that builds limbs with fingers and toes was around long before the acquisition of limbs, and that this toolkit exists in some primitive form in a living primitive bony fish, the paddlefish. We found that the genetic capability seen in tetrapods to build limbs is present in even more primitive fish," said Dr. Davis.

For their study, Dr Davis and his colleagues used the paddlefish as a proxy for a more primitive ancestor, as these fish have an elaborate fin skeletal pattern similar to that seen in more primitive vertebrates such as sharks and many fossil fish.

The researchers studied the development of paddlefish fins to test whether the genes activated to make hands and feet in tetrapods were different from the genes activated to make fish fins.

They looked at Hox geneswhich play a vital role in limb developmentin the pectoral fins of paddlefish, and to track where the Hox genes are active in the fin, inserted molecular markers into them.

Findings revealed that the activity pattern in the pectoral fins was very much similar to the genes responsible for the development of tetrapod limbs.

Tetrapods have a second phase of Hox gene expression that happens later in developm ent. During this second phase, hands and feet develop, and the scientists found this was present in the paddlefish.

In other words, the pattern of gene activity long thought to be unique to vertebrates with hands and feet is much more primitive, said Dr. Davis.


'"/>




Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Genes for lung disease
3. Genesis of SUPAC
4. Genes for Vision discovered
5. Genes Found To Help Leukemia Treatment
6. Cardiac Valve Disease Linked To Genes
7. Genes Linked To Cigarette Addiction
8. Genes from saliva may predict oral and breast cancer
9. Genes More Important Than Exercise for Bad Cholesterol
10. Genes responsible for social behavior of us
11. Genes to Extend Longevity Discovered
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2017)... ... , ... It's not always common knowledge whether or not a certain sickness ... to whether or not they are contagious, and most people don't know the answer ... took a look into the matter. , They discovered that the main reason ...
(Date:4/28/2017)... ... ... enough sleep affects much more than energy – it also has mental and physical benefits. ... motor reaction time, which can increase the risk of having a car accident. , ... the NSF to help you sleep better and feel better:, , ...
(Date:4/28/2017)... ... April 28, 2017 , ... The Radiology Business ... and officers for 2017-2018. The annual board election process has been in place since ... basis. , Thomas C. Dickerson, Ed.D., FACHE, succeeds Jim Hamilton, MHA, CMM, FRBMA, as ...
(Date:4/28/2017)... Harbor, Md. (PRWEB) , ... April 28, 2017 ... ... Care Association of America (UCAOA) and College of Urgent Care Medicine will host ... 2017 workshops, sessions and speakers will help those in the industry adapt to ...
(Date:4/28/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, has published ... He does not. Yisrayl says with so many titles and names for the Creator, ... says with a little Scripture, backed with a lot of research, the truth is undeniable. ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... April 19, 2017 The Global Effective ... to 2022 report has covered and analysed the potential of ... on market size, shares and growth factors. The report identifies ... and opportunities in the global market. ... Browse 152 Tables and Figures, 6 Major Company ...
(Date:4/19/2017)... , April 19, 2017 ... stimulate an immune response in pets such as ... products are of various types such as Attenuated ... Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated ... as virus or bacteria, which have been weakend ...
(Date:4/19/2017)... 2017  Novartis today announced the publication of ... and Blood Institute (NHLBI) of the National Institutes ... with treatment-naïve severe aplastic anemia (SAA) achieved complete ... at the initiation of and concurrently with standard ... sequential treatment groups, or cohorts. Cohort 3 added ...
Breaking Medicine Technology: