Navigation Links
Gene responsible for developing prostate cancer identified

Researchers from University of North Carolina have identified a molecule Ack1, which is responsible for suppressing the activity of Tumor// suppressor protein. Tumor suppressor protein is responsible for maintaining the integrity of cell and prevents the cell from developing tumor by maintaining a control growth of cell. Ack1 is found to be a growth promoting tyrosine kinase gene family. The results of the study has been published in the Journal Cancer research.

Tests of Ack1 demonstrate a profound effect on tumor growth in experimental systems, Earp said. 'It's a remarkable effect. Tumors grew more rapidly and invaded as if they were converted to advanced prostate cancer.'

Another major finding of the study involved an experimental drug developed by the National Cancer Institute, called geldanamycin. In laboratory tests, the UNC Lineberger group found Ack1 activity could be inhibited through interference with its molecular interactions, thus offering a target for treatment. First, the group discovered that Ack1 bound to a protein called Hsp90 (heat shock protein 90), which associated with many oncogenic, or cancer-causing, signaling proteins.

'If you add geldanamycin to the prostate cancer cell, the drug knocks Hsp90 off oncogenic signaling molecules. This dramatically decreases Ack1 activity and slows tumor formation,' Earp said.

In addition, the team compared Ack1 activation in advanced prostate cancer tissue from patients with that found in benign prostatic hypertrophy, or non-cancerous prostate enlargement. The team showed the levels of the activated Ack1 to be much higher in the advanced tumors.

'We saw that Mer was expressed at reasonably high levels in prostate cancer cells. And so Dr. Nupam Mahajan, the study's first author, decided to look at whether Mer had an effect on prostate cancer growth signaling,' Earp said. In experiments, which used the university's Michael Hooker Proteomics Core Facility, the team discovered that Mer activated Ack1. This finding led to the current study. 'Because we found Ack1 is more active in advanced prostate tumors, and its inhibition blocks experimental tumor growth, we believe Ack1 should be a target for novel drug development.'


'"/>




Related medicine news :

1. The right is responsible
2. Gene responsible for depression
3. Gene responsible for immune deficiency discovered
4. Genes responsible for social behavior of us
5. Molecule responsible for muscle repair identified
6. Genes responsible for cancer in women associated with increased cancer risk in men
7. Fixational eye movement responsible for visibility
8. Metal traces in infant formula cans responsible for recall.
9. Get that wedding ring on if you want to be branded a responsible parent!
10. Greater g factor in men responsible for sex differences in general mental ability
11. Molecule responsible for age associated macular degeneration identified
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... ... May 24, 2016 , ... Regenerative Medicine is being transformed by ongoing ... therapy technology, protocols and patient results as have been achieved with Okyanos Cell ... accessible standard of care for patients worldwide. , As the Medical Advisory Chairman at ...
(Date:5/24/2016)... New York, NY (PRWEB) , ... May 24, ... ... of rehabilitative treatment for physical disease or injury that focuses on repairing the ... surgery. , With an emphasis on functional restoration, NYDNRehab began providing treatments ...
(Date:5/24/2016)... ... ... A newly released report reveals that improving life outcomes for boys and men ... interactions and online. In “Heard, Not Judged – Insights into the Talents, Realities and ... digital devices can be an effective tool to help boys and men of color ...
(Date:5/24/2016)... ... May 24, 2016 , ... The ... clinical practice of radiosurgery, is recognizing five medical residents and students for their ... body radiotherapy (SBRT). The awards will be presented at the 2016 SRS/SBRT Scientific ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... Tuesday, May ... , The Yoga practice enhanced with Young Living Essential Oils, taught by Patti Dolan, ... at the Lake Orion location. Yoga Flow is 6:30pm - 7:15pm followed by a ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... , May 23, 2016 ... for the treatment of cancer and orphan genetic diseases, ... up to $4.4 million from the Israel Innovation Authority ... Israeli Ministry of Economy and Industry. The mission of ... entrepreneurship in various industries, including science and technology, while ...
(Date:5/23/2016)... May 23, 2016   Purdue Pharma L.P. ... an agreement with Egalet Corporation and Acura Pharmaceuticals, ... part of the agreement the companies will exchange ... all three companies to develop and sell several ... "This agreement reflects the commitment of Purdue Pharma ...
(Date:5/20/2016)... , May 20, 2016 ... 2016 to Medical Devices of its online business ... survey on the current state of the Titrator ... the industry like definitions, classifications, Specifications, applications and ... manufacturing process like Raw Material Suppliers, Equipment Suppliers, ...
Breaking Medicine Technology: