Navigation Links
Gene is related to premature ageing disease

Scientists from National Cancer Institute Maryland USA had found out a gene that is related to the disease of premature ageing// called Hutchinson-Gilford progeria syndrome.

The disease is caused by a point mutation in the gene called LMNA. This gene is one of the major genes that lead to the physiology of mammals and reside in mammalian cell nucleus. Fibroblasts from the individual with the disease have severe abnormalities in the nuclear envelope structure.

Scientists have not only identified the gene responsible for the progeria syndrome, but they have developed a process to reverse the symptoms. The process will eliminate mutant LMNA mRNA and lamin A protein using splicing correction to the activated cryptic splice site. On doing this, the HGPS fibroblasts become like normal cell nuclei. This helps in the proper _expression of the several deregulated genes that cause the disease.

The results show that it is possible to correct the genetic structure of the people suffering from premature ageing phenotype that characterizes patients with Hutchinson-Gilford progeria syndrome.

The study is published in the March issue of Nature Medicine.

Reference: Nature Medicine, March 2005

Page: 1

Related medicine news :

1. Heart disease in the newborn is related to maternal malnutrition
2. Individuals with sleep related breathing disorders more prone to heart disease
3. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
4. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
5. Dampness related to asthma
6. Allergies are related to mothers menses
7. Genetic disorder related with sleep patterns
8. Energy intake directly related to portion size
9. Treatment for cholesterol-related illnesses likely with the discovery of receptor in mice
10. New Drug Shows Significant Improvement In HIV-related Heart Condition
11. Sleeping Less May be related to Weight Gain
Post Your Comments:

(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, "Voices in ... that delves into an array of issues that are presently affecting Americans. Dedicated to ... dialogue, this show is changing the subjects consumers focus on, one episode at a ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men ... prominent nonprofit healthcare organizations in the country. They have overseen financial turnarounds, shown ... helped advance the healthcare industry as a whole through their advocacy and professional ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients ... central Michigan, have come together on Thanksgiving Day to share the things that ... viewing on the Serenity Point YouTube channel, patients displayed what they wrote on ...
(Date:11/26/2015)... , ... November 26, 2015 , ... ... workshops to discuss bioavailability and the need to integrate dose form selection in ... collaboration with OBN, the membership organization supporting and bringing together the UK’s emerging ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes ... titles work with any font, giving users limitless opportunities to stylize and create ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... -- --> --> ... potential to save costs, improve treatment quality and accelerate ... exploited as yet. Here, particular emphasis is placed on ... tablet or directly at the patients, bedside. ... -->      (Photo: ) ...
(Date:11/27/2015)... -- Research and Markets ( ) has announced ... 2015-2019" report to their offering. ... the author the present scenario and growth prospects of ... the market size, the report considers revenue generated from ... and copper IUDs. The report forecasts the global intrauterine ...
(Date:11/26/2015)... 26, 2015 Un nuevo enfoque ... para el cáncer avanzado.   --> ... fotodinámica de Bremachlorin para el cáncer avanzado.   ... inmunoterapia con la terapia fotodinámica de Bremachlorin para el ... . --> Clinical Cancer Research . ...
Breaking Medicine Technology: