Navigation Links
Gene in Melanomas

Research in mice has drawn a direct link between a human gene and the risk of melanoma, the deadliest form of skin cancer.A team led by Professor Marco Polo from the National Centre of Investigative Oncology in Sweden found that genetically engineered mice with a mutation in the gene, known as Cdk4, were more likely to develop melanomas when exposed to cancer-causing agents. Their results appear in the latest issue of the Proceedings of the National Academy of Cancers.//

Seventy four per cent of the Cdk4 mutant mice developed melanomas after being exposed to carcinogenic treatment, the authors report.The finding gives a better understanding of the body processes underlying melanoma, which could eventually lead to better treatments.

The Cdk4 gene has been known to be more common in people with melanomas, but this is the first time it has been established as a definite risk factor.The gene codes for the Cdk4 protein, a molecule that promotes cell growth and proliferation. Melanomas, like all cancers, are caused by the unregulated growth of cells that spread via the blood to other organs in the body.

The specific mutation in the Cdk4 gene renders the Cdk4 protein insensitive to a family of regulatory molecules that normally play a role in switching it off, known as INK4 proteins. The INK4 proteins usually have a 'double-negative' effect, blocking Cdk4's neutralising effect on another growth-suppressing protein. When INK4 proteins are disabled, cell growth continues unchecked.

The study of mice carrying the Cdk4 mutation will improve understanding of the complex series of events leading to the development and progression of melanomas.This knowledge, in turn, will allow the development of vaccines and other new anti-cancer drugs.


'"/>




Page: 1

Related medicine news :

1. Latest device for identifying Melanomas
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... March 24, 2017 , ... Northridge ... now offering treatments for sleep apnea and TMJ at their office. TMJ, or ... , specifically the obstructive type, is increasingly being treated at dental offices with ...
(Date:3/24/2017)... ... ... Viewers who like to educate themselves on current issues and who enjoy gaining knowledge ... tend to appreciate and love the "Informed" series, hosted by Rob Lowe. A ... around the world. , Running for charity has become a multi-million dollar ...
(Date:3/24/2017)... Frederick, Maryland (PRWEB) , ... March 24, 2017 ... ... LLC, is the first Certified Medical Reiki™ Master in Frederick, MD. Judy says, ... and their caregivers during what is often a very difficult and challenging time.” ...
(Date:3/24/2017)... ... ... “Vintage and Harvest A Cultivation of Christian Love” is the creation of published ... with his wife, Anna Marie. He and his wife are the proud parents of ... author of “Shadow and Substance.” , “Love, the agape kind, is seen as more ...
(Date:3/23/2017)... Greensboro, NC & Seattle, WA (PRWEB) , ... March 23, 2017 ... ... international public health emergency and now estimates that there could be four million Zika-related ... fastest growing epidemics to date with numbers of US cases reported per year skyrocketing ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... -- FinancialBuzz.com News Commentary   ... Medical cannabis products around the world are projected to gain ... medical cannabis market will reach a value of USD 55.8 billion by ... the new growing industry. By the end of 2016, 28 states have ... cannabis. More conservative states like Arkansas and ...
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... and Diagnostics, 2017 - 2035" report to their offering. ... The Deep Learning: Drug ... future outlook of the growing market of deep learning solutions within ... learning algorithms have emerged as a novel solution to generate relevant ...
(Date:3/24/2017)... , March 24, 2017 ... the industry including definitions, classifications, applications and industry chain ... international market including development history, competitive landscape analysis, and ... ... industry spread across 105 pages providing 10 company profiles ...
Breaking Medicine Technology: