Navigation Links
Gene in Melanomas

Research in mice has drawn a direct link between a human gene and the risk of melanoma, the deadliest form of skin cancer.A team led by Professor Marco Polo from the National Centre of Investigative Oncology in Sweden found that genetically engineered mice with a mutation in the gene, known as Cdk4, were more likely to develop melanomas when exposed to cancer-causing agents. Their results appear in the latest issue of the Proceedings of the National Academy of Cancers.//

Seventy four per cent of the Cdk4 mutant mice developed melanomas after being exposed to carcinogenic treatment, the authors report.The finding gives a better understanding of the body processes underlying melanoma, which could eventually lead to better treatments.

The Cdk4 gene has been known to be more common in people with melanomas, but this is the first time it has been established as a definite risk factor.The gene codes for the Cdk4 protein, a molecule that promotes cell growth and proliferation. Melanomas, like all cancers, are caused by the unregulated growth of cells that spread via the blood to other organs in the body.

The specific mutation in the Cdk4 gene renders the Cdk4 protein insensitive to a family of regulatory molecules that normally play a role in switching it off, known as INK4 proteins. The INK4 proteins usually have a 'double-negative' effect, blocking Cdk4's neutralising effect on another growth-suppressing protein. When INK4 proteins are disabled, cell growth continues unchecked.

The study of mice carrying the Cdk4 mutation will improve understanding of the complex series of events leading to the development and progression of melanomas.This knowledge, in turn, will allow the development of vaccines and other new anti-cancer drugs.


'"/>




Page: 1

Related medicine news :

1. Latest device for identifying Melanomas
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers care ... have a waiver for care if the client has a cognitive impairment diagnosis. ... for care, is often waived, so the benefits from their insurance start immediately,” said ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... now treating sleep apnea using cutting-edge Oventus O2Vent technology. As many ... sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer significant ...
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
(Date:10/12/2017)... FL (PRWEB) , ... October 12, 2017 , ... On ... holding a treadmill relay – Miles by Moonlight to raise money for the American ... $300 or more. , Teams will work together to keep their treadmills moving ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... WESTWOOD, Mass. , Oct. 4, 2017  According to the Centers ... by the end of October . PhysicianOne Urgent Care is helping communities ... Westchester, NY , by offering no-cost* flu shots through ... , as mandated by certain health insurance regulations. ... The best time to get a flu shot is by ...
(Date:10/2/2017)... announces the European launch of their new low volume, high throughput ... Cambridge, U.K on October 4th. The new ... unprecedented speed and sensitivity while using far less sample volume through ... ... ...
(Date:9/27/2017)... Israel and NEW YORK , Sept. 27, ... with mobile health and big data solutions, today announced that its MyDario ... Please check your local TV listings for when The Dr. Oz Show ... ... season this month. ...
Breaking Medicine Technology: