Navigation Links
Gene in Melanomas

Research in mice has drawn a direct link between a human gene and the risk of melanoma, the deadliest form of skin cancer.A team led by Professor Marco Polo from the National Centre of Investigative Oncology in Sweden found that genetically engineered mice with a mutation in the gene, known as Cdk4, were more likely to develop melanomas when exposed to cancer-causing agents. Their results appear in the latest issue of the Proceedings of the National Academy of Cancers.//

Seventy four per cent of the Cdk4 mutant mice developed melanomas after being exposed to carcinogenic treatment, the authors report.The finding gives a better understanding of the body processes underlying melanoma, which could eventually lead to better treatments.

The Cdk4 gene has been known to be more common in people with melanomas, but this is the first time it has been established as a definite risk factor.The gene codes for the Cdk4 protein, a molecule that promotes cell growth and proliferation. Melanomas, like all cancers, are caused by the unregulated growth of cells that spread via the blood to other organs in the body.

The specific mutation in the Cdk4 gene renders the Cdk4 protein insensitive to a family of regulatory molecules that normally play a role in switching it off, known as INK4 proteins. The INK4 proteins usually have a 'double-negative' effect, blocking Cdk4's neutralising effect on another growth-suppressing protein. When INK4 proteins are disabled, cell growth continues unchecked.

The study of mice carrying the Cdk4 mutation will improve understanding of the complex series of events leading to the development and progression of melanomas.This knowledge, in turn, will allow the development of vaccines and other new anti-cancer drugs.


'"/>




Page: 1

Related medicine news :

1. Latest device for identifying Melanomas
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2017)... ... , ... Antoine Dental Center is now offering various types of dental implants to ... a support for prosthetic teeth, such as crowns, bridges, or dentures. An implant is placed ... lasting new root for the tooth. , Several types of dental implants are available, ...
(Date:6/26/2017)... ... June 26, 2017 , ... A new and improved ... women look and feel about themselves and their sexual encounters. A unique medical ... urinary leakage head on with a ground breaking medical technique aimed to give ...
(Date:6/26/2017)... (PRWEB) , ... June 26, 2017 , ... New patients ... from Dr. Angela Cotey, with or without a referral. Dr. Cotey is a trusted ... of this preferred tooth replacement option. , Patients with missing teeth in Fitchburg, WI, ...
(Date:6/25/2017)... ... June 25, 2017 , ... An increase in wetter ... foliage and plants, and along with that; a humdinger of an allergy season. A ... also means an increase in misery-causing grass and weed pollen. , “Our patients ...
(Date:6/24/2017)... ... 24, 2017 , ... Genes Advice, a new company based ... and Texas doctors' offices and clinics. This breakthrough testing is part of the ... the role genes play in determining an individual's tolerance of and reaction to ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... , May 30, 2017 Therapix Biosciences Ltd. ... specializing in the development of cannabinoid-based drugs, today ... company overview at three upcoming scientific and investor ... LD Micro Invitational: ... Date:                     ...
(Date:5/24/2017)... Va. , May 24, 2017  ivWatch ... Original Equipment Manufacturer (OEM) Board to enable seamless ... with patient monitoring systems, infusion pumps and other ... OEMs will be able to help health care ... and reduced risks related to IV therapy. ...
(Date:5/18/2017)... WHIPPANY, N.J. , May 18, 2017  Two ... Healthcare Businesswomen,s Association (HBA) during its recent 28 th ... New York City.  The event showcases HBA,s longstanding mission ... the business of healthcare. Cindy Powell-Steffen ... in Bayer,s U.S. Radiology division, and Libby Howe ...
Breaking Medicine Technology: