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Gene determines pain threshold...

e other hand, augmented pain sensitivity was observed when BH4 was injected.

They conducted a study on 400 healthy individuals. They found that people with two copies of the protective version of "GCH1" were less sensitive to pain in tests, whereas those with only one copy had intermediate risk of developing chronic pain and those without any copy of the variant were at the highest risk.

"The drug used in the study, DAHP, is not very strong and is unlikely to be useful as a human medication, " said Woolf, who owns stock in a company called Solace Pharmaceuticals, which has licensed the findings for potential drug development.
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