Navigation Links
Gene determines pain threshold...

According to researchers, a gene determines people’s sensitivity to pain.In the study conducted on rats, the development// of chronic pain could be prevented by blocking the expression of that particular gene after a nerve injury or inflammation. This could be a breakthrough in development of new painkillers.

"Studies in volunteers showed that about a quarter of them had the genetic variant that protects them from pain somewhat, and three percent carried two mutated copies that make them exceptionally insensitive to pain, " the researchers reported in the journal Nature Medicine.

"This is a completely new pathway that contributes to the development of pain," said Dr Clifford Woolf of Massachusetts General Hospital and Harvard Medical School in Boston, who led the research.

"The study shows that we inherit the extent to which we feel pain, both under normal conditions and after damage to the nervous system." Chronic pain affects 1-in-5 adults or approximately 40 million Americans. The gene involved is called GCH1 that codes for an enzyme GTP cyclohydrolase that is required for the synthesis of a chemical called tetrahydrobiopterin or BH4.

"Our results tell us that BH4 is a key pain-producing molecule - when it goes up, patients experience pain, and if it is not elevated, they will have less pain," Woolf said in a statement. "The data also suggest that individuals who say they feel less pain are not just stoics but genuinely have inherited a molecular machinery that reduces their perception of pain. This difference results not from personality or culture, but real differences in the biology of the sensory nervous system."

Woolf and researchers in Germany and at the US National Institutes of Health said, "Rats with pain caused by nerve damage had higher levels of GCH1 gene activity and of BH4." The rats appeared to be less sensitive to pain when injecting a drug blocked the enzyme GTP cyclohydrolase. On th
'"/>




Page: 1 2

Related medicine news :

1. Viscosity of Women cervix determines sex of child
2. HIV Type determines turn-out of the disease.
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene determines pain threshold

(Date:8/28/2014)... To kick off the fall season ... One Spas retailers across the country are offering 0% ... The Hot Tub Tailgate Event is from August 29th-September ... more information and to apply early! , As the ... wide variety of outdoor hot tubs with exclusive features ...
(Date:8/28/2014)... 28, 2014) A fortuitous collaboration at Rice ... a recently discovered natural antibiotic. , The laboratory ... someday help bolster the fight against bacteria that ... around the world. , As part of ... structural biologist Yousif Shamoo and their colleagues created ...
(Date:8/28/2014)... researchers place glue directly on the nerve stumps, but ... and allows glue to easily invade the nerve ends. ... to insert the nerve ends into the conduit because ... Xiangdang Liang and co-workers from the General Hospital of ... technique and defined the best parameters for its use ...
(Date:8/28/2014)... be treated with nasal septum cells. Researchers at the ... cells taken from the nasal septum are able to ... can thus repair articular cartilage defects. The nasal cartilage ... environment is associated with the expression of so-called HOX ... has published the research results together with the report ...
(Date:8/28/2014)... OTTAWA, August 28, 2014 One in every 200 ... with the number of people living with the disease ... according to a study by researchers at the Institute ... Eastern Ontario (CHEO), and the Ottawa Hospital Research Institute. ... prevalence in the world. , The study, published this ...
Breaking Medicine News(10 mins):Health News:Synthesis produces new antibiotic 2Health News:Synthesis produces new antibiotic 3Health News:Synthesis produces new antibiotic 4Health News:From nose to knee: Engineered cartilage regenerates joints 2Health News:Ontario has one of the highest rates of IBD in the world 2
... ORLEANS, Sept. 28 Sanarus Medical today announced ... centers across,the country. These Centers, including breast care ... with Sanarus to,increase the awareness and availability of ... breast tumors, known as,fibroadenomas. Sanarus will host a ...
... Sept. 28 Today, at the Clinton,Global Initiative, ... total value is $1,000,000. Fulvio,Renoldi Bracco, Bracco AMT,s ... company and said that the partnership would provide ... Heart Hospital, in,Changchun City, Jilin Province, China -- ...
... N.J., Sept. 28 Whether she is giving a,keynote ... Esther Paik Goodhart conveys optimism and possibility. "Only ... I have,",says Goodhart with a warm laugh, "I,m a ... I teach Hebrew at three temples,and I,m running for ...
... Inc. ("NAI") (Nasdaq: NAII ), a leading,formulator, manufacturer ... be unable to file its Annual Report on,Form 10-K ... a timely basis because,it requires additional time to complete ... Annual Report on Form 10-K no later than,October 15, ...
... 28 Amid increasing pressure to combat,childhood obesity, the ... eleven-year-olds will lumber forward, breaking the $1,billion mark in ... the,U.S., a new report from market research publisher Packaged ... of kids, licensed food and,beverage products rose 9%, from ...
... University of Kentucky Center for Poverty Research has received ... Association of America Foundation (MOWAAF) to study the economic ... in America. , James Ziliak, Gatton Endowed Chair of ... at UK, part of the Gatton College of Business ...
Cached Medicine News:Health News:Sanarus Announces Partnership With Leading US Breast Care Physicians for the Next Generation Visica 2(TM) Treatment System for Fibroadenomas 2Health News:Bracco Announces Initiative to Save Children in China at 2007 Annual Meeting of CGI 2Health News:Humor and Hope Sustain NJ Woman Through Disabling Movement Disorder, Election Campaign 2Health News:Natural Alternatives International, Inc. Announces Late Filing of its Annual Report on Form 10-K, Revenue for Fiscal 2007 and Guidance on First Quarter of Fiscal 2008 2Health News:Natural Alternatives International, Inc. Announces Late Filing of its Annual Report on Form 10-K, Revenue for Fiscal 2007 and Guidance on First Quarter of Fiscal 2008 3Health News:Pressure to Promote Healthier Eating to Cause Minor Growing Pains for Kids' Licensed Foods and Beverages 2Health News:Center for Poverty Research to study senior hunger in America 2
(Date:8/28/2014)... , Aug. 28, 2014 Nonin Medical, Inc., ... in noninvasive medical monitoring, today announced that the Food ... 3231 OEM/eHealth finger pulse oximeter for use in ... oximeter plugs into a telemedicine hub or kiosk through ... rate in pediatric to adult patients. The Model 3231 ...
(Date:8/28/2014)... R.I. , Aug. 28, 2014  In recognition ... developing health complications from the flu, pneumonia, shingles ... ® have declared September to be Senior ... they age, it is important that adults ages ... on their vaccinations. CVS pharmacists and MinuteClinic nurse ...
(Date:8/28/2014)... Pa. , Aug. 28, 2014  Robotic ... patients, and media, both for the promise of ... safety. The quick deployment of surgical robots and ... are prompting facilities to evaluate their robotic surgery ... entire surgical team.    ECRI Institute ...
Breaking Medicine Technology:Nonin Medical Announces FDA Clearance of Nonin Model 3231 USB Pulse Oximeter 2September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 2September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 3September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 4Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 2Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 3Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 4Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 5
... 25, 2007 - Reata,Pharmaceuticals, Inc. today announced ... company's Synthetic Triterpenoid programs in,the May 2007 ... The article, "Triterpenoids and rexinoids as multifunctional,agents ... by researchers,and Reata scientific collaborators from the ...
... - Introgen,Therapeutics, Inc. (NASDAQ:INGN) today announced the publication ... survival,pathway impacts the anticancer activity of INGN 241. ... tumor killing effects of,INGN 241 in cell culture ... Introgen and The University of Texas M. D. ...
Cached Medicine Technology:Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 2Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 3Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 4Preclinical Studies Identify Novel Approach for Enhancing the,Anticancer Activity of Introgen's INGN 241 2Preclinical Studies Identify Novel Approach for Enhancing the,Anticancer Activity of Introgen's INGN 241 3
... Unique product designed for LASIK surgery ... to irrigate the corneal interface and/or stromal ... the flap and helps elevate the flap ... 7/8in (.40 x 22mm) Formed 9mm from ...
... designed for LASIK surgery and other types ... corneal interface and/or stromal bed. Flattened tip ... helps elevate the flap edge. Multiple ports ... x 22mm) Formed 9mm from end. Two ...
... designed for LASIK surgery and other ... irrigate the corneal interface and/or stromal ... under the flap and helps elevate ... multi-directional irrigation. 25G x 7/8in (.50 ...
... Cannula tip is specially ... insertion through wound and manipulation ... x 3.5mm, flexible tubing 25cm, ... 2mm. Unique annular rings ...
Medicine Products: