Navigation Links
Gene Variations Raise the Risk of Childhood Cancer Survivors

Despite surviving the risk of cancer, children were still at the threat of suffering from congestive heart failure due to the complication of the drugs they received during the cancer treatment//.

The researchers studied anthracyclines, a commonly used class of anticancer drugs known to cause heart damage in some patients. The research team investigated two groups of childhood cancer survivors, all of whom had been treated with anthracyclines. The study compared 47 patients with congestive heart failure (CHF) to a control group of 195 patients without CHF.

The researchers investigated 10 polymorphisms, naturally occurring variants in DNA bases called nucleotides, in seven genes they identified as having a role in biological responses to anthracyclines. 'We found that polymorphisms in the GSTP gene significantly increased a patient’s risk for CHF after treatment with anthracyclines,'said Dr. Aplenc. One polymorphism increased risk by five times; another variant was linked to a tripling of risk.

The research group chose particular genes as candidates for study because those genes carry the codes for enzymes involved in metabolizing anthracyclines and the reactive oxygen molecules that anthracyclines produce. If physicians can better classify gene variations that modify side effects of anticancer drugs, they may be able to better tailor treatment plans to individual patients. Thus, knowledge of a patient’s genetic makeup may allow physicians to select a more personalized, less toxic treatment.

'Further study needs to be done, using larger numbers of patients, to determine if these results hold up,' said Dr. Aplenc, a pediatric oncologist at The Children’s Hospital of Philadelphia, 'We hope these findings will provide a scientific foundation for safer, more effective cancer treatments for children.'

Dr. Aplenc’s research abstract was featured in a news conference at the ASCO meeting, which this year has a special focus o n cancer survivors. Dr. Aplenc is an attending oncologist at Children’s Hospital, where he researches gene variations in the enzymes that interact with chemotherapy drugs in children.

(Source: Newswie)

Related medicine news :

1. Variations In ingredients From Brand to Brand
2. Genetic Variations In Detoxifying Genes Lead To Lou Gehrigs diseases
3. Food Costs At Hospitals Show Mystifying Variations
4. Stroke Risk Higher with Gene Variations
5. Ethnic Variations in Hormone Levels May Cause Differences in Breast Cancer Risk
6. Large Variations in Cost Has No Effect on Length of Stay or Mortality
7. Genetic Variations Associated With Risk of Venous Thrombosis Identified
8. Variations of Post–Heart Attack Depression Affect Recover
9. Heavy Drinking Raises Risk of Liver Cancer
10. Swimming in Chlorinated Pools Raises Asthma Risk
11. New Treatment To Raise Good Cholesterol
Post Your Comments:

(Date:11/24/2015)... ... November 24, 2015 , ... Dehydration, defined as a loss ... to perspiration in the hot sun, and heat stroke and death will quickly follow. ... radio host Sharon Kleyne. Every cell, system and structure requires water to function properly. ...
(Date:11/24/2015)... ... 2015 , ... “I am so thrilled, as a newbie here, to leave a mark for ... $7,500 School Lounge Makeover® from California Casualty . Stephanie is in her fifth year ... much longer tenure. , “This is such an amazing school and we deserve a space ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... and safety labels , has been featured in the American Feed ... exclusively to representing the business, legislative and regulatory interests of the U.S. animal ...
(Date:11/24/2015)... ... ... Add a fresh touch to this year’s holiday festivities with indoor plants ... style and cheer to any space. , Holiday plants are more than just festive ... all year long. , “Holiday plants make a room come alive,” says Justin Hancock, ...
(Date:11/24/2015)... ... , ... On the pleasant autumn morning of November 15, 2015, nearly 130 ... for Autism held at Steep Rock Preserve in Washington, Connecticut. The run, which offers ... triumph. , Created and hosted by The Glenholme School, a special needs boarding and ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 24, 2015 Teledyne DALSA , a Teledyne ... technology, will introduce its CMOS X-Ray detector for mammography ... 29 to December 3, at McCormick Place in ... diagnostic and interventional imaging will be on display in the ... of advanced CMOS X-Ray detectors is the industry benchmark for ...
(Date:11/24/2015)... , Nov. 24, 2015  Enova Illumination is ... of Helsinki, Finland to combine ... are at the cutting edge of medical visualization: Enova ... the United States and Novocam ... Together, they provide the world,s most powerful battery-operated LED ...
(Date:11/24/2015)... Nov. 24, 2015  Freudenberg Medical has developed specialty tubing ... outside of medical facilities. Africa ... care is sparse. Nevertheless, prompt diagnosis is important to treat ... the virus. With the help of a portable mini-lab or ... to village in affected areas and perform rapid testing for ...
Breaking Medicine Technology: