Navigation Links
Gene Variations Raise the Risk of Childhood Cancer Survivors

Despite surviving the risk of cancer, children were still at the threat of suffering from congestive heart failure due to the complication of the drugs they received during the cancer treatment//.

The researchers studied anthracyclines, a commonly used class of anticancer drugs known to cause heart damage in some patients. The research team investigated two groups of childhood cancer survivors, all of whom had been treated with anthracyclines. The study compared 47 patients with congestive heart failure (CHF) to a control group of 195 patients without CHF.

The researchers investigated 10 polymorphisms, naturally occurring variants in DNA bases called nucleotides, in seven genes they identified as having a role in biological responses to anthracyclines. 'We found that polymorphisms in the GSTP gene significantly increased a patient’s risk for CHF after treatment with anthracyclines,'said Dr. Aplenc. One polymorphism increased risk by five times; another variant was linked to a tripling of risk.

The research group chose particular genes as candidates for study because those genes carry the codes for enzymes involved in metabolizing anthracyclines and the reactive oxygen molecules that anthracyclines produce. If physicians can better classify gene variations that modify side effects of anticancer drugs, they may be able to better tailor treatment plans to individual patients. Thus, knowledge of a patient’s genetic makeup may allow physicians to select a more personalized, less toxic treatment.

'Further study needs to be done, using larger numbers of patients, to determine if these results hold up,' said Dr. Aplenc, a pediatric oncologist at The Children’s Hospital of Philadelphia, 'We hope these findings will provide a scientific foundation for safer, more effective cancer treatments for children.'

Dr. Aplenc’s research abstract was featured in a news conference at the ASCO meeting, which this year has a special focus o
'"/>




Page: 1 2

Related medicine news :

1. Variations In ingredients From Brand to Brand
2. Genetic Variations In Detoxifying Genes Lead To Lou Gehrigs diseases
3. Food Costs At Hospitals Show Mystifying Variations
4. Stroke Risk Higher with Gene Variations
5. Ethnic Variations in Hormone Levels May Cause Differences in Breast Cancer Risk
6. Large Variations in Cost Has No Effect on Length of Stay or Mortality
7. Genetic Variations Associated With Risk of Venous Thrombosis Identified
8. Variations of Post–Heart Attack Depression Affect Recover
9. Heavy Drinking Raises Risk of Liver Cancer
10. Swimming in Chlorinated Pools Raises Asthma Risk
11. New Treatment To Raise Good Cholesterol
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene Variations Raise the Risk Childhood Cancer Survivors

(Date:12/20/2014)... Weddingshe.com has recently announced its new collection of sweet ... occasion dresses for the coming new year. , ... for global women. Now, all the models on its ... off. Among the new items, the model of 10986064 ... very popular. What’s more, Weddingshe.com also provides a fast ...
(Date:12/20/2014)... holidays can be anything but joyous for people with ... and other allergy triggers. "The dust from the ... away in dank basements or dusty attics is triggering ... Shah, an affiliate faculty member at Loyola University Chicago ... Shah, who is also an allergist at Gottlieb ...
(Date:12/20/2014)... Atore, Inc, (San Francisco, CA CEO: ... birthday focused portal on December 17th, 2014. , ... both US and Japan. , MERRY BIRTHDAY SITE : ... , MERRY BIRTHDAY MESSAGE is part of 5 ... , Features, Choose from thousands of stock photos to ...
(Date:12/20/2014)... The Twin Cities DI Day is ... the nation! Over 250 financial professionals come together each ... the industry, get motivated to protect their clients and ... and overcoming the challenges of disability. , On September ... came together to attend The 13th Annual Twin Cities ...
(Date:12/19/2014)... Sweetdressy.com , a leading wedding dress manufacturer for ... cheap prom dresses for ladies worldwide. The prom dresses ... clients can buy these dresses at the website of ... cuts and delicate craftsmanship, and most of them are ... shipping costs are available for all of their dresses. ...
Breaking Medicine News(10 mins):Health News:Tons of New-in Winter Sweet 16 Dresses from Weddingshe Online Now 2Health News:Holiday Trimmings Can Trigger Allergies 2Health News:Atore, Inc. Releasing the First Birthday Portal 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3Health News:Cheap Prom Dresses Online Now at Sweetdressy.com 2
... INDIANAPOLIS, May 29 People who favor,flip-flops as ... lower leg pain and a change in their stride, ... of the American College,of Sports Medicine (ACSM) in Indianapolis., ... with the observation,that most people appear to be wearing ...
... 83% of Patients ... Studied at 12 Months, ... of real-time medical imaging and image guidance,systems for the operating room, ... 12-month follow-up data,on patients treated with the OPTTX(R) System in commercial ...
... International Limited (NYSE: MR ), a leading ... announced the company and,its employees have together made ... Cross Society of China to help support the ... and Mr. Li Xiting,Mindray,s co-chief executive officers, together ...
... Conn., May 29 Complementary and alternative,medicine is ... presently,considered to be a part of traditional medicine. ... Services, nearly half of Americans use,complementary and alternative ... http://www.newscom.com/cgi-bin/prnh/20080415/NYTUFNS1 ), "The use of dietary ...
... designed and built a device to enable critically ill ... walk while remaining tethered to essential life-support equipment. The ... rehabilitation, as opposed to continuous sedation and bed rest, ... Some clinicians believe that allowing ICU patients to get ...
... May 29 More northern women feel bloating and,gurgling ... them likely to,experience it at any one time, according ... the West Midlands and Yorkshire and Humberside fared the,worst ... the least,amount of bloated feelings. And 61% of British ...
Cached Medicine News:Health News:Flip-Flops, Heels Examined for Performance, Impact 2Health News:Flip-Flops, Heels Examined for Performance, Impact 3Health News:Novadaq Updates on OPTTX Data Reported at Euroretina 2Health News:Novadaq Updates on OPTTX Data Reported at Euroretina 3Health News:Novadaq Updates on OPTTX Data Reported at Euroretina 4Health News:Mindray Donates Cash and Equipment for Sichuan Earthquake Relief 2Health News:Figure Skater Peggy Fleming Teams With HealthSaver: The Impact of Diet and Supplements on Health 2Health News:Figure Skater Peggy Fleming Teams With HealthSaver: The Impact of Diet and Supplements on Health 3Health News:Figure Skater Peggy Fleming Teams With HealthSaver: The Impact of Diet and Supplements on Health 4Health News:Figure Skater Peggy Fleming Teams With HealthSaver: The Impact of Diet and Supplements on Health 5Health News:Figure Skater Peggy Fleming Teams With HealthSaver: The Impact of Diet and Supplements on Health 6Health News:Students' device allows ICU patients to get back on their feet 2Health News:Students' device allows ICU patients to get back on their feet 3Health News:North South Divide Exists in UK Digestive Health 2Health News:North South Divide Exists in UK Digestive Health 3
(Date:12/19/2014)... , Dec. 19, 2014 You,re visiting ... checkup and cleaning when he or she says you ... probably heard before, you may have several questions and ... be relieved to know it,s nothing to worry about. ... patients, questions and alleviate any anxiety the public may ...
(Date:12/19/2014)... 2014 In today,s increasingly global marketplace ... to reflect the needs of a global marketplace ... the needs of key stakeholders while recognizing regional ... According to recent research by benchmarking firm, Best ... companies averaged more than $100,000 in annual spending ...
(Date:12/19/2014)... FORT WORTH, Texas , December 18, 2014 ... is a networked software application/module that is used ... and related images. RIS comprises a patient tracking ... tracking system. The integration of RIS with HIS ... is used for patient registration and patient scheduling, ...
Breaking Medicine Technology:Root Canals Have Become More Routine 2Building a Best-in-Class Pharma Global Brand Website 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3
... fibroid symptoms at least 5 years before,seeking treatment., ... annual meeting of the,American Association of Gynecologic Laparoscopists ... of a seven-country study measuring,the effects of uterine ... Researchers found that one in five women suffer ...
... Clinical trial data for Perforomist(TM) Solution presented ... Data from a Phase IIIb,clinical trial ... treatment provided prolonged bronchodilation,and increased patient satisfaction ... data were presented today in Philadelphia,at CHEST ...
Cached Medicine Technology:New International Study Shows Women With Symptomatic Fibroids Delaying Treatment Despite Substantial Burden on Quality of Life 2Nebulized Perforomist(TM) Inhalation Solution Provided Prolonged Bronchodilation and Increased Patient Satisfaction Compared to Albuterol/Ipratropium MDI 2Nebulized Perforomist(TM) Inhalation Solution Provided Prolonged Bronchodilation and Increased Patient Satisfaction Compared to Albuterol/Ipratropium MDI 3Nebulized Perforomist(TM) Inhalation Solution Provided Prolonged Bronchodilation and Increased Patient Satisfaction Compared to Albuterol/Ipratropium MDI 4Nebulized Perforomist(TM) Inhalation Solution Provided Prolonged Bronchodilation and Increased Patient Satisfaction Compared to Albuterol/Ipratropium MDI 5Nebulized Perforomist(TM) Inhalation Solution Provided Prolonged Bronchodilation and Increased Patient Satisfaction Compared to Albuterol/Ipratropium MDI 6
Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
For use with catalog #0540, 0887....
Enzyme Immunoassay of D-Dimer by ELISA Method, 96 tests....
Detection of Lupus Anticoagulants. Freeze-dried hexagonal phase phos-phatidylethanolamine; normal plasmawith heparin inhibitor; PTT-LS reagent of cephalin and particulate siliceous activator;all free...
Medicine Products: