Navigation Links
Gene Variations Raise the Risk of Childhood Cancer Survivors

Despite surviving the risk of cancer, children were still at the threat of suffering from congestive heart failure due to the complication of the drugs they received during the cancer treatment//.

The researchers studied anthracyclines, a commonly used class of anticancer drugs known to cause heart damage in some patients. The research team investigated two groups of childhood cancer survivors, all of whom had been treated with anthracyclines. The study compared 47 patients with congestive heart failure (CHF) to a control group of 195 patients without CHF.

The researchers investigated 10 polymorphisms, naturally occurring variants in DNA bases called nucleotides, in seven genes they identified as having a role in biological responses to anthracyclines. 'We found that polymorphisms in the GSTP gene significantly increased a patient’s risk for CHF after treatment with anthracyclines,'said Dr. Aplenc. One polymorphism increased risk by five times; another variant was linked to a tripling of risk.

The research group chose particular genes as candidates for study because those genes carry the codes for enzymes involved in metabolizing anthracyclines and the reactive oxygen molecules that anthracyclines produce. If physicians can better classify gene variations that modify side effects of anticancer drugs, they may be able to better tailor treatment plans to individual patients. Thus, knowledge of a patient’s genetic makeup may allow physicians to select a more personalized, less toxic treatment.

'Further study needs to be done, using larger numbers of patients, to determine if these results hold up,' said Dr. Aplenc, a pediatric oncologist at The Children’s Hospital of Philadelphia, 'We hope these findings will provide a scientific foundation for safer, more effective cancer treatments for children.'

Dr. Aplenc’s research abstract was featured in a news conference at the ASCO meeting, which this year has a special focus o n cancer survivors. Dr. Aplenc is an attending oncologist at Children’s Hospital, where he researches gene variations in the enzymes that interact with chemotherapy drugs in children.

(Source: Newswie)
'"/>




Related medicine news :

1. Variations In ingredients From Brand to Brand
2. Genetic Variations In Detoxifying Genes Lead To Lou Gehrigs diseases
3. Food Costs At Hospitals Show Mystifying Variations
4. Stroke Risk Higher with Gene Variations
5. Ethnic Variations in Hormone Levels May Cause Differences in Breast Cancer Risk
6. Large Variations in Cost Has No Effect on Length of Stay or Mortality
7. Genetic Variations Associated With Risk of Venous Thrombosis Identified
8. Variations of Post–Heart Attack Depression Affect Recover
9. Heavy Drinking Raises Risk of Liver Cancer
10. Swimming in Chlorinated Pools Raises Asthma Risk
11. New Treatment To Raise Good Cholesterol
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2016)... ... ... a half of planning the Multiple Pathways of Recovery Conference , CCAR is pleased ... held May 2 -4, 2016 at the Mystic Marriott Hotel & Spa . ... pathways individuals use to get into and sustain their recovery. Pathways of recovery are ...
(Date:5/27/2016)... ... May 27, 2016 , ... More than a third of American adults are ... bariatric surgery has received increased attention in recent years, as an article ... to weight loss, most people are familiar with the basic requirements of maintaining a ...
(Date:5/27/2016)... Newark, NJ (PRWEB) , ... May 27, 2016 , ... ... been named as YWCA Tribute to Women and Industry (TWIN) 2016 honorees. The ... to their workplace. For this year, Geri Boone, Director of the MLTSS (Managed Long-Term ...
(Date:5/27/2016)... ... May 27, 2016 , ... An influential resource amongst nurses and ... to shed lights on the variety of topics detailing why we appreciate nurses in ... why this career has gone from being in a major recession to one of ...
(Date:5/27/2016)... ... May 27, 2016 , ... This campaign aims to provide a path to ... society can control and change. , As nearly 795,000 Americans suffering from a new ... United States. Plus, with an estimated 129,000 of these people dying from stroke, it’s ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)...  Diana Russell suffers from a form of rheumatoid ... out.  This disease has put her in a wheelchair, ... grandchildren to leave her home.  Because of the size ... the wheelchair.  So if there is a family function, ... left to wait for the bus. Photo ...
(Date:5/24/2016)...  NxStage Medical, Inc. (Nasdaq: NXTM ), ... care, today announced that Jeffrey H. Burbank , ... schedule of investor conferences. Where applicable, a webcast of ... .   ... Friday, June 10, 2016 1:30 p.m. ET ...
(Date:5/24/2016)... Marziani has joined VMS BioMarketing as senior vice president of sales, announced Andrea ... Marziani will lead the company,s business development and sales team, exploring new opportunities for ... - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
Breaking Medicine Technology: