Navigation Links
Gene Variants Linked to Preterm Birth in Hispanic Women

Four gene variants in Hispanic women are linked to spontaneous preterm birth, according to researchers at Yale School of Medicine and Washington University.//

The research was presented at the Society for Gynecologic Investigation Conference in Reno, Nevada on March 16.

Preterm birth is a major cause of illness and death in newborns. A genetic cause of preterm birth was suggested by racial disparity, a tendency to occur within families and a high rate of recurrence, according to Errol Norwitz, M.D., associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale and lead investigator of the study.

Norwitz and his team prepared DNA samples from 102 mothers with a spontaneous unexplained preterm birth and 408 mothers who delivered at term with no complications. They then compared the distribution of 128 well-known genetic variations, known as single nucleotide polymorphisms, in 77 genes between the two groups. The patients in the study were identified from the March of Dimes Perinatal Epidemiology Research Initiative Project at Yale and New York University between January 1989 and June 2005.

"Our analysis demonstrates that, in an Hispanic population, mothers who carried any one of four polymorphisms were significantly more likely to have a spontaneous preterm birth," said Norwitz.

The four polymorphisms included CYP2C9S144, IL6S174, CCR5S1 and ENPP1S121. The risk of preterm birth was highest among women with the ENPP1 variant.

"The strong association of ENPP1 was particularly compelling, but how this variant functions and why it predisposes preterm births still needs to be determined," said Norwitz.

In another abstract using the same study subjects, Norwitz and colleagues explored whether polymorphisms in the gene that encodes the progesterone receptor may identify women at risk for preterm birth. The team found no such association.

"Progeste rone supplementation may prevent preterm birth in about 30 to 40 percent of women at high risk by virtue of a prior preterm birth, but exactly how progesterone supplementation works is still unknown," said Norwitz. "While this was a negative finding, it was an important question to answer."

Source-Eurekalert
PRI
'"/>




Related medicine news :

1. Gene Variants Linked to Early Heart Attack Discovered
2. Striking a Gold Mine: H5N1 Vaccine may Serve as an Antidote for Mutants and Variants
3. Susceptibility Of TB In Humans Might Be Due To Three Human Gene Variants
4. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
5. Cough Syrup Ingredient Linked to Stroke
6. Irregular Periods Linked to Diabetes
7. Hormones Linked To Migraines
8. Triglycerides Linked To Stroke Risk
9. Smoking Linked To Low Infant Birth Weight
10. Nausea Linked To Anxiety And Depression
11. Painkiller Linked to Deaths
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/20/2017)... ... September 20, 2017 , ... ... Coating System for clients that rely on safety and cleanliness. This unique flooring ... , Silver has been used for centuries for its antimicrobial properties. Unlike antibiotics, ...
(Date:9/20/2017)... Calif. (PRWEB) , ... September 20, 2017 , ... ... year of providing a voice for people who have kidney disease. The theme ... writers to share their stories. Entrants needed to meet only one qualification— ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... company specializing in medical device compliance and commercialization, has just released a ... activities. , FDA is more adamant than ever about medical device, pharmaceutical, ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... of exhibitors at the East-coast edition of MarTech: The Marketing Tech Conference October ... bring together more than 40 speakers — representing such thought-leading companies as ...
(Date:9/20/2017)... ... September 20, 2017 , ... As part ... company recently unveiled a redesigned website. The new site – still located at ... owners, architects, contractors and other industry users that Garland serves. , After an ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... 6, 2017  Medical professionals are expected ... while treating their patients. Medical simulations offer ... involving patients. Simulation provides a safe method ... out procedures, refine techniques and build confidence, ... new technology, such as augmented reality, will ...
(Date:9/5/2017)... another milestone in their continued growth and success of the company.  Xyntek has ... engagements regionally.  ... at 318 West Adams Street, Suite 1528, Chicago, IL ... Xyntek's recently opened Midwest office will support the ... In addition to Xyntek,s headquarters ...
(Date:9/1/2017)... -- Explorers Like Us ( https://explorerslikeus.com/ ) is embarking on "An ... deliver these experiences as part of Life Environments™, a new ... better. ... nothing beats a walk, jog or simply playing in a ... the next best thing when getting there isn’t possible. Life ...
Breaking Medicine Technology: