( Four gene variants in Hispanic women ar...)Gene Variants Linked to Preterm Birth in Hispanic Women,Health

Four gene variants in Hispanic women are linked to spontaneous preterm birth, according to researchers at Yale School of Medicine and Washington University.//

The research was presented at the Society for Gynecologic Investigation Conference in Reno, Nevada on March 16.

Preterm birth is a major cause of illness and death in newborns. A genetic cause of preterm birth was suggested by racial disparity, a tendency to occur within families and a high rate of recurrence, according to Errol Norwitz, M.D., associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale and lead investigator of the study.

Norwitz and his team prepared DNA samples from 102 mothers with a spontaneous unexplained preterm birth and 408 mothers who delivered at term with no complications. They then compared the distribution of 128 well-known genetic variations, known as single nucleotide polymorphisms, in 77 genes between the two groups. The patients in the study were identified from the March of Dimes Perinatal Epidemiology Research Initiative Project at Yale and New York University between January 1989 and June 2005.

"Our analysis demonstrates that, in an Hispanic population, mothers who carried any one of four polymorphisms were significantly more likely to have a spontaneous preterm birth," said Norwitz.

The four polymorphisms included CYP2C9S144, IL6S174, CCR5S1 and ENPP1S121. The risk of preterm birth was highest among women with the ENPP1 variant.

"The strong association of ENPP1 was particularly compelling, but how this variant functions and why it predisposes preterm births still needs to be determined," said Norwitz.

In another abstract using the same study subjects, Norwitz and colleagues explored whether polymorphisms in the gene that encodes the progesterone receptor may identify women at risk for preterm birth. The team found no such association.

"Progeste
'"/>




Page: 1 2
Related medicine news :

1. Gene Variants Linked to Early Heart Attack Discovered
2. Striking a Gold Mine: H5N1 Vaccine may Serve as an Antidote for Mutants and Variants
3. Susceptibility Of TB In Humans Might Be Due To Three Human Gene Variants
4. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
5. Cough Syrup Ingredient Linked to Stroke
6. Irregular Periods Linked to Diabetes
7. Hormones Linked To Migraines
8. Triglycerides Linked To Stroke Risk
9. Smoking Linked To Low Infant Birth Weight
10. Nausea Linked To Anxiety And Depression
11. Painkiller Linked to Deaths