Navigation Links
Gene Variant associated with Schizophrenia identified

According to a team of researchers from the Edinburgh University, the risk of development of psychotic symptoms is higher in people with a variant of a gene called// neuregulin.

This study was published in the journal Nature Neuroscience. 200 youths at high risk of developing schizophrenia were monitored for 10 years in this study. As schizophrenia is a hereditary disorder, all the volunteers had 2 or more relatives affected by this condition. All of them were of the age group 16-25 years at the beginning of the study, the vulnerable age at which the symptoms were expected to develop.

The researchers conducted interviews, brain scans, psychological tests and genetic analysis in their study. Their findings revealed that volunteers with a variant of the gene neuregulin were more likely to develop psychotic symptoms like paranoia or hearing voices linked with schizophrenia, than those with out the variant.

This was confirmed by brain scans that showed that abnormal brain activity in the frontal and temporal regions were more likely to occur in people with the gene variant. These changes are usually linked to schizophrenia.

Previous studies have revealed that a gene linked to brain development is controlled by this gene variant. These findings could help in the development of treatment.

Dr Jeremy Hall, lead researcher on the paper, based at the division of psychiatry, Edinburgh University, said: "These major mental illnesses have really been for a very long time a big black box in terms of what is causing them - it is not that long ago that people thought you got schizophrenia because you had a bad mother. And treatments have not advanced a lot over the last 50 years.

"You have to understand more about what causes diseases before you can start designing treatments for it. "These results help us to understand how a gene might alter brain function and then cause symptoms, and could represent a target for treatments in the future."

Dr James MacCabe of the Institute of Psychiatry, Kings College London, said: "It is a very interesting study, and, potentially, quite an exciting one.

"We have known for years that schizophrenia had a genetic contribution, but until quite recently no genes had been found.

"Over the past five years there have been about 10 possible genes identified, and neuregulin is a very promising gene."

He said: "It is a relatively small study and will have to be repeated on a much larger scale, but if the results hold true the findings would be significant.

"The next stage would be to understand how a defect in this gene causes schizophrenia so as to understand the neurobiology of the disorder and design treatments that could reduce the symptoms."

Marjorie Wallace, chief executive of the mental health charity Sane, said: "There have been so many hopes of finding a gene for schizophrenia which have ended in a cul-de-sac.

"If this latest research were to prove a breakthrough and lead to understanding what causes schizophrenia, we could at last find more effective treatments and potential cures, transforming the future for the one in 100 who suffer from this devastating condition."
GYT
'"/>




Related medicine news :

1. Gene Variants Linked to Early Heart Attack Discovered
2. Striking a Gold Mine: H5N1 Vaccine may Serve as an Antidote for Mutants and Variants
3. Susceptibility Of TB In Humans Might Be Due To Three Human Gene Variants
4. Tougher Guidelines Needed To Prevent Variant Creutzfeldt-Jakob Disease
5. You may Live Long and Think Clear With a Variant Gene
6. Gene Variants Linked to Preterm Birth in Hispanic Women
7. Use of Cellular Phones associated with Increased risk of Brain Tumors
8. Memory loss associated with microbes
9. Osteoporosis associated with Childhood Cancer
10. Toxin injections support stroke associated spasticity
11. Migraine & Juvenile stroke could be associated
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... ... 05, 2016 , ... In sleep, when the defenses of the day are ... of patients with eating disorders is significant self-criticism, and consequently these patients experience this ... regarded as maladaptive means for coping with this unease, but also leads to a ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... kitchens, recently announced the debut of their latest mobile kitchen model, featuring customizable ... organizations with modern, high-volume commercial kitchens for use anywhere in the U.S. Many ...
(Date:2/5/2016)... , ... February 05, 2016 , ... Calls Blacklist has ... completely new user interface design and the developer has fixed known bugs within the ... want to on their phone while not consuming any of their device’s battery power ...
(Date:2/5/2016)... ... ... –This week, Atascadero water heater company First Call Plumbing has issued ... report, click here or see below. , There are two main ... the type chosen is almost entirely up to personal preference. However, tankless water heaters ...
(Date:2/5/2016)... , ... February 05, 2016 , ... When one is tired of trying to cram ... There are many reasons to rent a storage unit, but before hastily spending money on ... sometimes you simply need more space. But what one is often not told when utilizing ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... --  Bernstein Liebhard LLP today announced that a securities ... Court for the District of Arizona ... persons or entities who purchased common shares of Insys Therapeutics ... March 3, 2015 through January 25, 2016 (the "Class Period").  ... violations of the Securities Exchange Act of 1934.  ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 Summary ... most common cancer and the most common cancer in ... making the disease exceedingly prevalent. The number of women ... few decades, but the number of deaths has declined ... Breast cancer treatment has been revolutionized in the past ...
(Date:2/4/2016)... -- Mettler-Toledo International Inc. (NYSE: MTD ) today ... the highlights: , Sales in local currency ... year.  Reported sales decreased 3% as currency reduced sales ... earnings per diluted share as reported (EPS) were $4.44, ... EPS was $4.65, an increase of 10% over the ...
Breaking Medicine Technology: