Navigation Links
Gene Therapy Overcomes Heart Failure In Muscular Dystrophy

Researchers at the University of Pittsburgh have successfully treated heart failure in an animal model that is genetically //prone to develop a human muscular dystrophy. The article detailing this study is published in the Oct. 25 edition of the journal Circulation. The authors say that this is the first time that a gene therapy has been used in a therapeutic way.

Lead author, Xiao Xiao, Ph.D., associate professor of orthopedic surgery at the University of Pittsburgh School of Medicine said that attempts to treat the muscle with genes directed at it have been successful because of inherent characteristics of the muscle itself, 'Previous attempts at systemic gene therapy for muscle have not been very effective because blood vessel capillaries act much like a mosquito net, blocking the gene drugs from reaching the muscle cells. Fortunately, we found a virus that is just small and sneaky enough to get through this net and deliver the therapeutic gene to both skeletal and cardiac muscle cells,' he said.

The virus that was successfully used to deliver the gene to the muscle is named the adeno-associated virus, or AAV, a class of relatively small viruses that do not cause any known disease. Dr Xiao and his team used the AAV-8, which can penetrate the capillary net and thus can be effective in whole body treatments. The team tested this therapy against limb girdle muscular dystrophy, or LGMD. In humans, this condition leads to severe damage and weakness to muscles, particularly around the hips and shoulders and the heart. Naturally, the lifespan is shortened owing to cardiac and respiratory failure. The injection of a high dose of AAV-8 was accompanied by significant improvements in the skeletal and cardiac muscle tones in the affected hamsters. After eight months of gene therapy, the hamsters were found to have completely normal hearts. The untreated LGMD animals died of heart failure or other complications of muscular dystrophy by 37 weeks, while the t reated animals survived beyond the study period of 48 weeks. 'When we began the experiment, we anticipated that the treatment would be effective. However, we never imagined it would be so effective, particularly in protecting against or reversing the damage to the heart caused by this mutation and extending lifespan,' concluded Dr. Tong Zhu, M.D., Ph.D., a research associate in the department of orthopedic surgery and the first author of the study. 'In fact, if this study holds up in human clinical trials, it may have profound implications for the treatment of heart failure.'


'"/>




Related medicine news :

1. Cancer Doctors Okays Controversial Prostate Therapy
2. Consensus on "Combination Therapy" for Breast Cancer
3. Gene Therapy shows promise in treating Hemophilia
4. "Make AIDS Therapy affordable" - Physicians demand
5. Hormone replacement Therapy a headache
6. Simple Therapy
7. Therapy for stopping the spread of cancer cells
8. Gene Therapy Destroys Pancreatic Cancer Cells
9. Letrozole Beats Tamoxifen in Breast Cancer Therapy
10. Garlic Supplements Impede HIV Therapy
11. Gene Therapy For Cystic Fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/14/2019)... ROSWELL, Ga. (PRWEB) , ... January 14, 2019 ... ... information related to the use and availability of VARIZIG® (Varicella Zoster Immune ... its website ( https://bit.ly/2M1l0UR ). In the update, the CDC notes that VARIZIG ...
(Date:1/14/2019)... , ... January 14, 2019 , ... ... availability of the newly updated International Audit Protocol Consortium (IAPC) EHS audit protocol ... audit protocols to understand the scope of their EHS regulatory obligations and rapidly ...
(Date:1/13/2019)... ... January 13, 2019 , ... Dr. Christine Kaczmar, a functional medicine doctor ... How The Broken Medical Model Is Creating More Sickness And Why Timeless Healing Principles ... our health...Symptoms. Dr. Christine explains that judging our health by how we feel ...
(Date:1/11/2019)... ... 11, 2019 , ... Women’s Excellence Obstetrics and Gynecology announces ... Zaidan, President of Women’s Excellence, will co-host WJR’s "Health Women Show" with WJR’s ... at 7pm. , "We are excited to partner with a longstanding, reputable organization ...
(Date:1/10/2019)... , ... January 10, 2019 , ... ... that it has partnered with MD101, a regulatory consulting company that serves the ... core expertise in servicing companies in the medical device and healthcare industries. Based ...
Breaking Medicine News(10 mins):
(Date:1/14/2019)... BOLOGNA, Italy (PRWEB) , ... January 13, 2019 , ... ... markets, is proud to announce the Memor™ 10 rugged mobile computer , one ... , MEMOR™ 10 is part of a new family of rugged Android PDA ...
(Date:1/11/2019)... ... 11, 2019 , ... Isagenix International , known for ... gut health. The global health and wellness company just launched IsaBiome™ Daily Digestive ... support better daily digestion of meals and long-term gut health.† The products were ...
(Date:1/10/2019)... , ... January 10, 2019 , ... ... office location in Baltimore, Maryland. The new location, at 312 Martin Luther King ... and home to a growing team of healthcare professionals. , Dr. Bryan Morrow, ...
Breaking Medicine Technology: